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  • BDD Moderators: Keif’ Richards

Methadone messing up my opiate tolerance?

Siccness909

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Could Methadone have messed up my opiate tolerance if I only took it for a week? I was taking it for recreational purposes it wasn't prescribed to me. I was dosing like 4-6mgs a day for a week? And this was like 4months ago? Basically I can't get high on 20mgs of Vicodin anymore...I always kept my opiate tolerance low and now it doesn't affect me anymore?! I haven't dosed on opiates in months either!...thoughts?
 
Mmmh. Yes, methadone would of course affect your opiate tolerance (remember that it's a very strong drug!) but if it was 4 months ago I wouldn't think it still has an effect. How long could you use those 20mgs hydros for without needing to dose up, and have you been taking them regularly since the methadone? The methadone might be entirely unrelated honestly, if you've been doing opiates/opioids regularly since that would increase your tolerance, even if they're weaker.
 
If you only took 4-6mgs for a week and that was 4 months ago there is no way that the methadone is still affecting your tolerance. Taking a few months off should definitely make a huge dent in your tolerance but it isn't going to reset back to zero. What opiates and in what doses were you taking before you took your months off? Knowing this is really important to answer your question.
 
I was taking 15-20mgs of Hydrocodone since I started doin opiates like 2 years ago! But i was never addicted or did it regularly I've always been high from.that dose, and I literally mean that I was never dosed consistently to affect my tolerace I was very smart with drug use for awhile. But 2 months ago i tried doing 20mgs Vicodin and it didn't affect me? So.i figured it was the Methadone I took 4months ago...I now once again have acquired 40mgs of Vicodin and I wanna dose but I don't know if it's gonna affect me like last time? I haven't done opiates in months so I don't get it...also someone told it may require me to dose 40mgs of hydrocodone to get high again due to the Methadone?...I don't have time to CWE n.I got the 5/500's so I'm hoping to dose 20mgs again and get high but yeah I don't know what's gonna happen and I don't wanna kill my liver wit all the apap dosing higher you know? But anyway any thoughts on what I should do?
 
Eventually with long-term use of opioids it gets to a point where your brain just doesn't respond in the same way anymore. The high is never as good as it was in the beginning, even with long breaks. I don't think it was directly from using low doses of methadone for 1 week a month ago, probably just from using opioids in general. As Mass08 said, tolerance doesn't really reset back to zero once you've used opioids for a while, even if you take a break.

There could also be other factors though, for example do you use any other drugs?

ETA: You should always go on the assumption your tolerance could be low after a break and start with a low dose. You can always take more if it's not enough but you can't undo it if you take too much. Taking 8 Vicodin (to get 40mg hydro) would also be a lot of APAP, that's 4000mg at once. It's not wise to exceed 3000-4000 over a 24 hr period (depending on the source); taking 4000 at once is not a good idea.
 
Yeah your Guy's answers are making more sense I probably should throw out the methadone factor and just assume it's finally my tolerance to opiates in general. I will try for 25mgs and hope for the best I guess. I also was always dosing 15 to get high not 20mgs my mistake so you think 25mgs would have effect? I honestly don't think I've ever dosed on 20mgs+ with opiates at once
 
I would just try 20mgs and then wait ~1.5 hours and see how you feel. If you aren't satisfied take more. You absolutely should be CWEing these though. 4000mg is a lot of APAP.
 
I thought redosing was pointless with opiates? Well 20 is sedating but not euphoric I.can feel I'm close to my level but just not their with 20..Im gonna try 30mgs total so 2 more pills would be 3000mgs of apap? Can I dose that just this once?
 
Alright yeah well I dosed one more making 25mgs and I started to feel it so to make it 30mgs I feel Id be at my level. So yeah i guess in conclusion my tolerance was just raised over time. Sucks lol. Anyway thanks to everyone who.helped glad I figured out my dose now.
 
Yeah of course methadone, despite some not deeming it euphoric, has a very strong bonding affinity and has a very long half life. As it stays in your system ,the methadone starts to build up so while you only take 5mg, ou probably have 10mg of methadone in your system at a time.

The strong affinity and long half life will literally cause you tolerance to sky rocket especially with daily use.

I remember the days when I got sooooo faking high from 20mg oxycodone, but after taking suboxone for a long time, even 45mg of oxy didn't do shit but take me out of withdrawal...


Get used to your new tolerance because that is DEFINITELY the name of the game....
 
Exactly what laCster said. Only way to keep tolerance minimal is to ONLY use partial agonists and use very infrequently. Full agonists can really increase tolerance fast, especially with repeated use.
 
I wouldnt throw it out the window because I had the same thing happend to me. I did a tenth of h in the am and a tenth at night for years. My connection got busted so i bought some methadone. I only took it for two days I think it was four 10mg tabs on the third day I got more h (dealer bonded out thanks to me and my bad habbit) and I no longer got a good high from a tenth. I just maintained no fun after that.
 
I wouldnt throw it out the window because I had the same thing happend to me. I did a tenth of h in the am and a tenth at night for years. My connection got busted so i bought some methadone. I only took it for two days I think it was four 10mg tabs on the third day I got more h (dealer bonded out thanks to me and my bad habbit) and I no longer got a good high from a tenth. I just maintained no fun after that.

You still had methadone in your system, of course your usual dose of heroin wasn't going to get you high. Plus, 40mg of methadone over two consecutive days is going to build up in your system with every redose since it's still active and make your tolerance go up very rapidly. And I'm sure the heroin on the 3rd day FURTHER increased your tolerance, even if you didn't get high.

Methadones half life is extremely long compared to other opiates, anywhere from 24-36 hours.

The OP is NOT in the same situation. He hasn't had methadone in 4 months.
 
I know that is all true. I just meant to say after the methadone I never got high anymore. But before the methadone I used the same amount for over two years with the same results (got high everytime)(euphoria). That is why I went to my doc and had him put me on methadone. I thought I could quit since if I didnt get the euphoria anymore. I was more stupid back then and didnt realize the long term effects. I am off it now only 12 days but this is the furthest I have ever gone without since it began. I just really think that once I took that methadone my body handled opiates differently. imo. You are right though and sorry if I went off the OP.<3
 
Don't worry about it, it's still good info and all. I don't believe two days use of a total of 40mgs of methadone is going to permanently raise your tolerance, but continued usage of other opiates regularly afterwards IS. That is what more than likely ruined your tolerance, while the methadone kick started it still being in your system that third day and using heroin. Tolerance is a bitch, but good job on 12 days. Keep it up.
 
Not so long ago I've read some threads in the Advanced Drug Discussion which I can't exactly find in regards to methadone: Something along the lines of methadone nearly permanently saturating opioid receptors in turn significantly increasing tolerance in chronic use, but I'm unsure if there's any substance to those claims.

Some studies actually concluded that methadone can significantly decrease tolerance from morphine based opioids through its mechanism as an NMDA-antagonist.
 
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