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  • BDD Moderators: Keif’ Richards | negrogesic

methadone and stomach ph

punkftl

punkftl

Bluelighter
Joined
Feb 4, 2004
Messages
207
Location
Ft. Lauderdale, Florida
does methadone absorption depend on the ph of the stomach? i know that some drugs will poorly absorb if the stomach environment is too acidic, such as dexedrine and taking antacids with it increases it's absorption.

and some drugs will not absorb well if the stomach environment is not acidic enough, like taking antacids with xanax inhibits its absorption.

i take 140mg. of methadone liquid in the morning and sometimes have really bad heartburn or acid reflux when i wake up...and was just wondering if this is preventing the methadone from absorbing well...thanks
 
ive always heard eat a good meal after dosing, and ive always heard take some zantac<rantidine.?sp a good meal always seems to make me humm a lil bit, i know aloy of it is the person and their body... i tell my friends that if i taker 10mg of done at 1pm monday i feel more "fucked" up Tuesday morning when i open my eyes i can lay in bed for a hour just itchin and scratching
 
sometimes i will drink 100% pure grapefruit juice 30 minutes before, or take 4 tagamets.
see i was always told that taking methadone with food will decrease it's absorption rate..i will have to try and eat something then..thanks!
 
ok, i read that the reason why eating something with fat in it increases the methadone because methadone is lipid (fat) soluble, and the blood brain barrier is more permeable to lipids (fats), fats cross it more rapidly.

so when ingested, the methadone binds to the fat and therefore passes easier through the blood brain barrier.
and that eating a couple of tablespoons of peanut butter does it well.
anyone tried this or have heard of someone that has tried it and it works?
 
past 2 days ate 2 tablespoons of peanut butter right after dosing and noticed that the methadone kicked in and made me feel really good like it did when i first started taking it and it alleviated my back pain..
not sure if it is because methadone is fat soluble or the power of suggestion..all i know is that i will be eating peanut butter everyday now!
 
Yes, pH does matter with Methadone. Certain drugs which lead to a more alkaline environment in the body/stomach/digestive system can potentiate Methadone. Sodium Bicarbonate for example. This leads to a slower excretion of Methadone. Acidifiers like large doses of Ascorbic Acid (Vitamin C) can do the opposite, lead to faster excretion of Methadone.

Source:

http://pain-topics.org/pdf/Methadone-Drug_Intx_2006.pdf
 
thanks!
my men's daily multi-vitamins contain a lot of vitamin C..i dose at 9am in the morning and take my vitamins around 3-4 in the afternoon...would anyone recommend not taking vitamin c at all?
 
I took some sodium bicarbonate yesterday, so I'll see if it holds me longer with my methadone.

@punkftl: yes, I assume you should stop taking vitamin c. Although I'm taking a lot of fruits in my daily diet, so I don't really know.
 
loulou reed said:
I took some sodium bicarbonate yesterday, so I'll see if it holds me longer with my methadone.

@punkftl: yes, I assume you should stop taking vitamin c. Although I'm taking a lot of fruits in my daily diet, so I don't really know.
Click to expand...


yeah, let me know how if the sodium bicarbonate worked or not...did you take it before or after the methadone...and how many hours before/after..thanks
 
punkftl said:
yeah, let me know how if the sodium bicarbonate worked or not...did you take it before or after the methadone...and how many hours before/after..thanks
Click to expand...

I took around one gram just after dosing. As my metabolism is super slow (I can abstain from methadone for 3 to 4 days before feeling bad), I didn't notice anything.
Be careful though as sodium bicarbonate is a salt, so although it's good for a lot of things, I don't think it's good to take some every day for a long period of time.
 
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