Methadone and Opana for pain relief.

[closeau]

New to this but I'll give it a try. I was wondering the same thing. I'm on 40mg of Methadone a day for chronic pain due to blood clots in legs. My pain Dr will not prescribe me anything for breakthrough pain. I'm in a lot of pain and cannot sleep...or really walk. He raised my methadone just this last week so he wont go up for another 3 months. I have the oppurtunity to get Opana IR 5mgs. I was wondering if anyone out here has tried that combination and what effects it had. Im not really looking to get high but if it relieves my pain, I'm willing to try it out. I know about QT depression and stuff. If not Opana, what about OxyContin? I've gotten so much conflicting info I was looking to get the info from somebody who has experience. Thanks bunches and yall be safe out there!!

 

[Pjkt2501]

Closeau, welcome. It's encouraged for participants to make new threads for specific, individual questions. It'll prob get moved / merged or whatever.

Anyhow, to answer your question: Opana (oxymorphone) is a very powerful opiate with a good binding profile. The receptor binding affinity is what's the issue here, given that maintenance drugs such as methadone or suboxone prevent other opiates from binding to receptor sites. I don't think you'll be getting the full-blocking effects of methadone @ 40mg/day. So to say; those Opana 5mg IR's may just do the trick for you.

You seem to be a legitimate CP patient, not someone looking for recreational purposes, so take this as you will: Oxymorphone (Opana) has a terribly low oral BA, but a wonderful BA when insufflated. I don't know how keen you are on snorting powders (Opana is somewhat bad too - the silicified microcellulose crystalline matrix that makes up the release mechanism is bad for pretty much all parts of the body), so take it for what it's worth. If insufflation is something you'd consider, then depending on the size of the pill (and thus the amount of filler) you'll want to do small lines at a time for best absorption. If it all just drips down your throat it's no different than having crushed / sifted it out and just swallowed it, but with some complimentary congestion as well.

Best of luck!

 

[Tripman]

Like PJ said, it's better to make your own thread than bump a year old thread. You will get more replies and not derail other threads.

So I made this for you :D.

 

[Pjkt2501]

http://www.youtube.com/watch?v=kN-Rl2c39Yc

Anyway, word.

I do think the 5mg IR's will be beneficial to you medically.

 

[closeau]

Thanks for the info you guys. I'll let ya know how it works. I obviously dont know what I'm doing on this site. How do I place my own thread or move what I got already. Would hate to have to type it again, haha. Maybe Ill figure it out. Aint rocket science. I'm hurtin bad due to my clots but relief is in sight. Thanks again!!

 

[Howdoesitfeel?]

Closeau, welcome. It's encouraged for participants to make new threads for specific, individual questions. It'll prob get moved / merged or whatever.

Anyhow, to answer your question: Opana (oxymorphone) is a very powerful opiate with a good binding profile. The receptor binding affinity is what's the issue here, given that maintenance drugs such as methadone or suboxone prevent other opiates from binding to receptor sites. I don't think you'll be getting the full-blocking effects of methadone @ 40mg/day. So to say; those Opana 5mg IR's may just do the trick for you.

You seem to be a legitimate CP patient, not someone looking for recreational purposes, so take this as you will: Oxymorphone (Opana) has a terribly low oral BA, but a wonderful BA when insufflated. I don't know how keen you are on snorting powders (Opana is somewhat bad too - the silicified microcellulose crystalline matrix that makes up the release mechanism is bad for pretty much all parts of the body), so take it for what it's worth. If insufflation is something you'd consider, then depending on the size of the pill (and thus the amount of filler) you'll want to do small lines at a time for best absorption. If it all just drips down your throat it's no different than having crushed / sifted it out and just swallowed it, but with some complimentary congestion as well.

Best of luck!

If he's getting 5mg IR's, isn't the silica a non-issue, since they're not extended release?

 

[Pjkt2501]

If he's getting 5mg IR's, isn't the silica a non-issue, since they're not extended release?

That's an excellent point. I've only come across the yellow 40mg ER versions in the past. I do now believe I've read that these are easily prepped for IV, which would imply the silica doesn't exist.