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Methadone and Bicarbonate (Alka Seltzer)

S

spaceyourbass

Bluelighter
Joined
Apr 7, 2008
Messages
1,749
I did several searches with different combos of the words methadone/bicarbonate/alka seltzer with no results.

Is it true that Alka Seltzer, which contains sodium bicarbonate (and caffiene), potentiates methadone? When is the best time to take the Alka Seltzer if I'm using it to potentiate? I have quite a tolerance BTW, so there's no risk of OD because of the Alka Seltzer. Thanks for any relative information.
 
Please don't bump posts... people will answer the Q just be patient.
AFAIK, no, you're confusing bicarb with potentiation of amphetamines, or confusing cimetidine potentiation of certain opiates.
 
Yes I am thinking you are confusing the very potent effect of sodium bicarbonate on absorption of METHamphetamine or amphetamine. I think the METH in both names has caused your confusion. If you are on maintenance then there is little you can do to boost your buzz which will disappear fast. Try to remember that in some places there are waiting times of over a year to get on 'done and many truly want to get clean. Not preaching, but its true. Good luck and I hope you find what you are looking for.
 
Practice Googling.

A gift:

". . . the longer the Methadone remains in the stomach, the greater adverse ratio degradation to absorption (The longer it is in the stomach, the more the chemical degrades, while very little absorption occurs)

...

Gastric absorption was increased by alkalinization of stomach contents "

Would consuming substances to make the stomach environment more alkaline prior to consuming Methadone/Ginger further potentiate the effect?

Also, would consuming an additional CYP2D6 and/or CYP3A4 Inhibitor at the time of M/G ingestion further enhance the subjective physiological effects of the Methadone by slowing down its metabolism?
Click to expand...
-Me

http://www.bluelight.ru/vb/showthread.php?t=403101&highlight=methadone+ginger

Substances that increase the effects of Methadone:

Urinary alkalinizers: Sodium Bicarbonate

Alkaline (higher pH) urine decreases
methadone excretion by kidneys (Kalvik et al.
1996; Strang 1999).
Click to expand...

-Methadone Drug Interactions 3rd ed. 11/2005.

Another good thread on a related note (and one of mine :))

http://www.bluelight.ru/vb/showthread.php?t=403333&highlight=methadone+g-spot
 
djsim - I usually never do that, but it went to page 2 in about 10 minutes flat. So I bumped, my bad.

Tchort, it was your posts that generated my interest in this topic! (In the first post) You were pretty much asking for validation of a kinda-hypothesis, and no one answered. So I thought I'd try again. Thanks for the input everyone.
 
I'm glad you found it interesting. It was Valentine4 that got me hooked on learning about Methadone metabolism- on the plus side I know a little more than Wikipedia than before, on the downside I haven't found a viable oral Methadone enhancement.

While I respect Valentine4 just by the few posts of his I've seen, I haven't been willing to test the theory due to poor responses from other Methadone metabolism tinkerers. Taking Ginger,Sodium Bicarb, Tagamet, Prilosec, Orphenadrine, Lexapro, Benzo's, Prozac, then injections of Cyclizine and Barbital to try and make Methadone into something it is not, and wasn't meant to be. If it were meant to be rapid acting, short acting, induce a breatheless rush, etc it would've been born that way :) It doesn't matter how much Tagamet and homemade Diconal and god knows what else you eat, it won't make it so.

The only advantage I've found to any of these chemicals in relation to Methadone is that Tagamet (Cimetidine) and probably other CYP3A4 Inhibitors prolong the duration of effects and increase the depth of sedation. For opioid addicts, this makes the feeling well business easier by making a little Methadone go a longer way. Similarly, MMT patients who abuse their takehomes use it to boost serum levels to get through the days they skipped their doses more comfortably.

I wrote a lot about Orphenadrine (Norflex), though I would be interested in trying it, I don't even believe the theory I put forward in the M-G-Spot thread- that the combo via IV or even orally would be some brave new world.

Anyway, the science is interesting. Very few other recreational drugs' metabolism has piqued my interest like Methadone. Other than the joy from learning something new, none of this stuff will enhance euphoria, and may possibly cause harm via discomfort, side effects of individual medications, oversedation-coma-death, etc.

For some reason, the odd day the warm & fuzzies from taking MMT dose on an empty stomach hits me, if I were to consume any of the above mentioned substances, they wouldn't have shown up at all. Save yourself some frustration and don't bother.
 
does alka-seltzer change methodose levels in urine tests?

I have a question about methodose liquid and alka-seltzer being in the body at the same time.
My question is ....can taking methodose liquid from a methodone maintenence program be affected by having alka-seltzer in your body?

My reason for this inquiry is that....first of all I will give you the facts....I have been in a methodone maintenence program for four and a half years now. I have been on 153 mgs. for the last year and the time before I was up to 175mgs. I take my dose each day as I should and my weight is around 230 lbs. at 5'11'' tall. Now normally one time per month I am required to give a urine sample and I did give one last friday a week ago.
Well come a few days later a tuesday I get a call from the clinic saying I need to come in and give another urine because the one I just gave came up saying that I had no methodone in my system! Now I find this very wrong as I always take my medicine as I should though as I was thinking of it...lately the past month I have been drinking a ton of alka-seltzer due to the fact that I have two ulcers. I mean I go through at the least about one box of 36 (that is 18 packets of two) per week. (the alka-seltzer seems to work better then any medicine the doctor gave me so that is why I take it.)-but anyway this last month I have had alot of stress and because of that I have been using more alka-seltzer.
I do not understand why my urine would come up nothing for methodone.
Could this just be a mistake on the urine test or is there something in alka-seltzer that eliminates the methodone or even possibly it was due to the amount I had taken?
I hope someone out there has an answer for me as now the clinic I go to thinks I am up to something-and I really would like to have a leg to stand on because I have worked too dam hard to get to this point as is.
thank you everyone..and god bless.
-wondering in philly
 
A friend of mine accidentally overdosed on magnesium hydroxide (milk of magnesa) and found his done quite noticably potentiated. He was also on a GF regimen at the time.
 
Wondering in philly, you know alka seltzer has aspirin in it, right? Aspirin will only exacerbate your stomach ulcers and hell, might even have caused them.
 
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