Opioids methadone after nubain

[misspharmacyashley]

i injected maybe 10mg or less of nubain last night and have walked into a situation where i can get some methadone tonight. would this be safe? i know taking the nubain after taking methadone could trigger withdraws but i'm wondering if the methadone would even have an effect on me tonight or if i should just wait to take it later.

i've tried looking up some information on this here and google but it seems there's not a lot at all anywhere.

 

[NeighborhoodThreat]

I would wait to take the methadone, I know Nubain is a trade name for the semi-synthetic opiate nalbuphine, but I don't know much about its interactions with methadone (as far as one being a competitive agonist for the opiate receptor or not...).

From wikipedia's article on nalbuphine:

Although Nalbuphine possesses narcotic antagonist activity, there is evidence that in nondependent patients it will not antagonize a narcotic analgesic administered just before, concurrently, or just after an injection. Therefore, patients receiving a narcotic analgesic, general anesthetics, phenothiazines, or other tranquilizers, sedatives, hypnotics, or other CNS depressants (including alcohol) concomitantly with Nalbuphine may exhibit an additive effect. When such combined therapy is contemplated, the dose of one or both agents should be reduced.

 

[misspharmacyashley]

thanks dude, i will definietly be waiting to take the methadone.

the nalbuphine was cool for about 30 minutes then i just felt really relaxed (not a bad thing), then finally passed out after a few hours and had some crazy dreams. i'd say it was 'alright' - not gonna complain though, free is always good in my book. it was definitely not worth not being able to dose tonight though.

oh well, ya live and ya learn. 8)

 

[inept enigma]

for GOD'S SAKE, never take the shit when you are a daily methadone user! I have gone through every opiate withdrawal there is and this makes an 8-bag/day heroin habit kick look like a walk in the park. My fucking friend said it was "Demerol" then I actually looked @ the vial. I KNOW, I KNOW, that was stupid as hell and I should've looked @ it 1st...goes to show, never over-estimate your druggy-friends' burnt-out brain cells I injected only 25 units and it felt like ice-cold water being poured down my back, then the water started to burn like lava, then I began to sweat profusely and have near-constant dry-heaving. I was literally kicking the walls w/ my feet and SCREAMING. I used to think I had a half-way decent pain-tolerance and laugh @ people who couldn't take a jones, but this shit brought me to my knees. Thing is, I've detoxed myself down from 90mg of methadone/daily to 20-25mg and the effects were still this extreme. Is Nubain 2 seperate chemicals (an agonist and antagonist) or a single drug that acts as both like buprenorphine?

 

[Znegative]

It's a single drug, like buprenorphine. I've actually been really interested in trying it myself.

The OP isn't a daily methadone user though, so it wouldn't trigger withdrawals. The question is whether it would block the methadone or not. According to Wikipedia the half life (well, it actually says metabolism but I'm assuming they're referring to half life) is 3-6 hours, so I would imagine after 24 hours it would be fine to take the methadone

 

[Ashbabe2685]

Horrible experience with nubain just happened to me today! Make a long story short, I went to the dr with a migraine, was throwing up bc it hurt so bad. He gave me promethazine shot then wanted to give me 1 for pain. I didn't disclose the fact that I'm on 50mg a day of methadone (stupid, I know) bc I didn't want to be looked at with disgust & treated like less of a person. I know we can't have stadol, so I made sure it wasn't that, but they just said they were giving me a "synthetic analgesic narcotic." They gave me the shot & 10 min later I started feeling like there's fire in my chest. I told the dr but he didn't seem concerned, said is normal. Another 5 min goes by, the fire is now going up my neck & down my arms & I'm starting to get VERY anxious & irritable. Plus I'm on fire on the inside, freezing on the outside, & have terrible stomach cramps. I ask the dr if it could have anything to do with me being on methadone, he says yes it'll cause w/d. At that point I REALLY start to freak out & the dr just has them give me a Benadryl shot to calm me down, says there's nothing else he can do & asks me if I want him to call an ambulance & go to the ER. I know how the er treats people on methadone, so I just go home. By then the Benadryl shot has hit me and I'm super sleepy. When I wake up, I'm fine. No w/d symtoms what so ever! My question is, is it normal for w/d symptoms to just go away like that after taking nubain?? I thought they'd last until I could get back to the clinic for my next dose.

 

[Ashbabe2685]

Also, since I was just given the nubain today, will I be able to feel my methadone dose tomorrow?

 

[Serena697]

My hack doc injected me with 10mgs of nubain, knowing I take 80mgs daily of methadone, for the past seven years, for severe chronic spine pain. I was having a very bad flare up and has asked him if there was anything he could give me for breakthru pain. He suggested nubain,I had never heard of it but stupidly trusted him.

Five minutes into it, hell commenced. The lava under my skin and in my veins, agonizing pain, hallucinations, terror and uncontrolled screaming at the top of my lungs. For five horrible hours I was rolling and flopping around on his office floor, begging for an ambulance. Later, I begged for death. My heart rate was out of control, and I was sweating so profusely I could wring sweat out of my clothes. I was banging my fists and head into the walls and tile floor to stop the agony, the tremors, the hallucination.

It was by far the worst physical experience of my life. I was convinced I was going to die. What upsets me so much is my doc simply warned me that at most, the nubain "might lower the effectiveness of the methadone in my system." He asked, and I honesty told him, that the last time I took methadone prior to the injection of nubain was four hours prior.

He is blaming the entire thing on me. He insists I should have "put two and two together and understood" that when he said the nubain may lower the effects of methadone, that it also meant that it could trigger instant withdrawal. Then he blamed me by failing to tell him I don't wait a full 12 hours in between each methadone pill.

He is dead wrong. Methadone has a relatively long half life, meaning even if we did wait twelve hours before injecting nubain, methadone would've still been in my system and withdrawal would've occurred. He insists my reaction was unforeseeable and highly unusual. This is the bastard that refills my meth scrip every month, and he knows my med history very well.

I cannot express just how betrayed I feel. I would only wish that experience on the most evil of people. He refused to take me to a hospital or give me anything to calm me down, or even get me a damn blanket. I was freezing, rolling around on his tile floor.

He claims he's used nubain on methadone users (for extra pain relief) two times. Clearly he is inexperienced and did not educate himself of the effects of nubain on an chronic methadone user such as myself, and I paid a terrible price.