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  • Trip Reports Moderator: Cheshire_Kat

Mescaline ( Higher Dose ) - Experienced - "Soul annihilating overdose"

Newmoonrecord

Bluelighter
Joined
May 24, 2007
Messages
1,030
I just wanted to throw this piece of information out there so maybe people can benefit from it with future use. It's my theory now, that combining psychedelics with zofran (selective serotonin antagonist) vastly increases their potency. I'm an experienced mescaline user - have used countless times and it is my favorite psychedelic. Last night was the first time I combined a full breakthrough dose with zofran (anti nausea) though. I believe that the fact that mescaline was displaced from 5ht3 (nausea) receptors by zofran caused mescaline to basically bind everywhere else instead. I used a dose that i have standardized (liquid extract) in the past and that would probably give me decently great open eye visuals, gradual ego destruction, and significant mindmelting (ie: a +++ experience). This time, however, what i experienced was the most mindblowing cosmic trip Ive ever taken. (beyond +4, if that's possible)

About 15 minutes in, I started feeling the juicy phenethylamine bodybuzz, like warm hands massaging my body. I also felt like my awareness was widening to include more than the immediate space around me. The air felt thick and everything began to become beautiful. At this point i started getting a little nervous - mescaline had never come on so fast before, and I figured I was in for a hell of a strong trip. Well, as some of us have experienced, mescaline comes in waves, and 30 minutes in, the first rush had ended, leaving me wanting more, and so i drank the rest of the tea as I had initially prepared.

About 1.5 hours in I felt like my trip had just passed the point of intensity that matched the highest peak of any of my previous experiences Whoa. Knowing i wasnt going to be peaking for 5 more hours, I figured I would be lucky to survive with my sanity intact, so I downed .5mg xanax, set up my stereo system, and prepared for the ride. An hour later (t+2.5hours) I had pretty much forgotten that I had taken mescaline, i didnt know what words were, what being human meant, or what mescaline even was, I was just riding the infinite waves of consciousness that had somehow expanded beyond any boundaries that I had even glimpsed before. Originally worried about a wrenching ego death - at this point it wasnt even an issue. My ego had disappeared before I could even notice it.

For all intents and purposes - i had left the real world behind. I couldnt understand anything, and i was unable to physically move because I had forgotten how. (my body felt like the universe). The next 4 hours were spent inside my head, experiencing perfect unity in/with the cosmic void, trying to tune out the outside world due to the most massive amount of synesthesia i had ever encountered. My body buzz was flowing to the melody of the music and both were intersecting with the open and closed eye visuals in a 5dimensional way.

Around 7 hours in, i finally had enough wit about me to smoke some high quality bud, which marked the turning point from total mind fuck into psychedelic ecstasy - I finally was able to move, walk around, and recognize my physical environment. I spent the rest of the trip marvelling at the most spectacular OEVs that I've ever encountered. Plumes of gold and purple fire waterfalls out of my walls, and neon flashes and strobe lights underlying everything, and those were just the ones that I could put into words. It was definitely the most beautiful experience and scene that I've ever witnessed, visually and mentally.

For the record: I felt back to baseline at about t+16 hours. The longest trip Ive ever taken.

A few comparisons and footnotes. This was stronger than my previous strongest mescaline experience by about a factor of 3, and I have tripped balls on mescaline. The peak of this trip far surpassed my peaks on psilocybin and dmt (both of which i am very inexperienced with), and also lasted 4 hours instead of a half hour. Up until this point, I did not think it was possible to go to that same place (that i glimpsed bits and pieces of on tryptamines) on mescaline. Well, it is. It's just a bit more uncomfortable. I wasnt able to integrate any of it (too powerful), but nevertheless Im very glad i experienced it. I did experience many moments of physical agony, as may sometimes occur with mesc- in this case it was stomach cramps caused by not puking it up like i usually do. (due to the influence of zofran, im sure). In future trips, when I use zofran im going to use less mescaline and also probably use pod tea to relax my intestines (plus the mescaline and opiate buzz is ridiculous).

Hope this helps someone. While I believe that zofran is still the best drug ever invented for psychedelic users - it's all i can think of that would have resulted in what was effectively a doubling of the potency of my dose.

Despite being completely overwhelmed with the cosmos being jammed into my head, and the physical agony of intestinal cramps combining with a phen overdose, and having my mind unbelievably blown, I'm ready to do it all again next weekend.

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very well written. i hope i can experience something similar someday. easy on the tripping :D
 
this report has about a 90% chance of starting a zofran craze among psychedielc drug addicts.
 
Top notch report, my man. Five stars. I thoroughly enjoyed it. :)

Zofran? Is it safe?

[No source discussion, even vague]
 
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addendum: some of the increase in my dose was probably because i didnt puke.

[No mentioning of availability]
 
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Great report. Care to share what the exact mescaline dose was?

I looked up Zofran, aka Ondansetron. I'm not sure whether a 5HT3 antagonist can increase receptor binding for a 5HT2A agonist. But if nothing else it looks like it would prevent and treat the nausea from mescaline well. I probably wouldn't order it just cause I'd feel weird buying medications intended for chemotherapy patients.
 
^^ Well, I wouldn't feel weird getting some Marinol in the mail, now if only I had a cpl hundred bucks to blow...
 
IndoleDreamStudies said:
Great report. Care to share what the exact mescaline dose was?

I looked up Zofran, aka Ondansetron. I'm not sure whether a 5HT3 antagonist can increase receptor binding for a 5HT2A agonist. But if nothing else it looks like it would prevent and treat the nausea from mescaline well. I probably wouldn't order it just cause I'd feel weird buying medications intended for chemotherapy patients.

i wish i knew. i actually had forgotten how much it was. i had a nalgene full of concentrated syrup extract and i got so used to measuring doses in ml amounts, i dont even remember how much cactus i had used when i did the extraction 6 months ago. and yeah, on my 2nd or 3rd time thinking about it, im also unsure as to whether zofran really caused my overdose, but im sure it contributed somewhat. At the very least, it prevented me from puking up what would have been impossible to keep down otherwise.

and since you liked my report, do you guys think it would be worth the effort for me to write up some more mescaline reports ? i usually trip on it about 3-5x a month and there seem to be relatively few on here.
 
trancedeviate said:
Yeah that would be good. So you only trip on mescaline? Would be nice to hear some others too! :)

pretty much exclusively. i have a lot of it, and i didnt really like acid, mushrooms are hit and miss in terms of being able to get them, and they are sometimes too crazy for me. Im going to try dmt some more sometime soon after i obtain some more maois. I'll probably write up some mescaline trip reports this week.
 
just a note for the thread: the trip mentioned in the original post ended up kind of messing me up for a while, i tripped out frequently whenever i smoked a lot of pot, and sometimes still have problems with frame of reference and losing my perspective when i get high now, ever since the trip. It's getting gradually better though.
 
How potent is that cacti extract you have? How much ml do you take of it? Is it some vile green sludge?

The one and only time I did it I just ate a big piece of cactus :/
 
^^^^ Yeah, I want to know if the OP could estimate his dosage in milligrams of a pure salt, if at all possible.
 
I've tried trimethobenzamide (200 mg) with pure mescaline hcl before and didn't have any noticable nausea. It wasn't a ridiculously high dose though ... just 420 mg.

How much zofran did you use? Orally, right? I have a few vials of injectable ondansetron (4 mg). I'm interested in possible interactions that could be going on here. Maybe I'll try it with a psychedelic, except take the psych first to see if the zofran takes it up a notch. Have you tried it again since? Thanks.

Great report by the way! ;)
 
I used a total of 8mg of ondansetron, (4mg 2 hours prior, and 4mg an hour into the trip, all orally), although it is my suspicion that it wore off, given that i experienced intense nausea around the 8 hour mark. I'd recommend two 8mg doses - one at the beginning and one about halfway through. I've used zofran for a lot of other drugs with positive results. It worked for me with opiate induced nausea (to some extent). I dont think there's an overdose level or a dangerous level that needs to be worried about with it.

I dont have any mescaline dosage meter to compare it to, but from what i've heard , - 1000mg is the level for total craziness, i suspect i was probably at around 800-900mg
 
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