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Tryptamines Mescaline hcl microdosing schedule and dosing?

Coffeeshroom

Coffeeshroom

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Okay so I got my hand on some Mescaline hcl to use for microdosing.

The reason is to lower my daily methadone and benzos use to the lowest point possible and then from there swap over to other stuff I want to microdose and use in the getting clean or completely off it.

I have done a few not a lot but most research that I could get ahold off and this is what I have come up with. Questions or 4 points I have so far

1. Microdosing dose should be 5-10% of the therapeutic/dose that will give full effects, dose 200-400mg of Mescaline sulphate which converts from research to 178-356mg Mescaline hcl.
Seeing as I have Mescaline hcl, at minimum 8.5mg to 17mg..
So going with a 5-10% dose, that will be 8.5 - 17mg Mescaline hcl microdosing.

2. Is the dosing schedule.
So far I have found 2 days on 2 days off
5 days on and 2 days off.
2 days on 5 days off. In other words alot of different schedules or ways to approach it but I think I'm gonna lean towards the half life of the drug and with that I was thinking dosing eod.

3. Time frame. A minimum of 4 weeks and max of 8 weeks, guess all dependent on the substance used for this. So was thinking 6-8 weeks depending on how I do the dosing.

4. My dosing. Seeing as my 5-10% dose will be between 8.5mg-17mg if I'm correct. So day 1 start with 5 drops and increase 1 drop eod till I get to 17mg.

So with all said and typed any info or pointers, help, input, warnings and etc would be gratefully appreciated.

From the 4 points I made I would like to know if I'm correct in my calculations on dosing and dosing regime. So any input to any of the points would be gratefully appreciated.

@Shinji Ikari I know you have microdosed Mescaline, what was your dose and regime and so all if you don't mind me asking.

Sidenote after this I want to then turn over to blue and pink lotus with sceletium. Hoping to use that in the period when I want to get off the methadone.

So wanna use the Mescaline microdosing to lower my methadone usage to low as possible in the 40 days roughly I will be using it, though I can make it 60 days, I think. Still need to do some calculations And then after that use the lotus and sceletium in the full wd phase, also will have benzo and gabapentinoids as comfort meds but wanna try do this without them if possible. but that is a convo for later, for now it's just the microdosing of the Mescaline and if I'm on the right path.

Then also I'm still looking for a natural alt for mood stimulation and energy as just sativas is not gonna cover it purely for get up and go motivation and energy in those lethargic days.

My plans so far. I have already stocked up on 400mg Mescaline hcl. In a dropper bottle. 1ml = 13.3mg Mescaline hcl. Have 4 different strains of RSO for the off days. Off days I'm thinking of dosing 0.1ml of RSO which = 75mg thc and days off half the dose, so 0.05ml RSO = 37.5mg thc.

I got the following RSO strains 1ml of each except 2 of the Chocolate Haze
Chocolate Haze - Sativa ( currently using, mornings only 0.05ml )
Watermelon Zkittlez - Hybrid Indica dominant
Tart pops + slurricane - hybrid indica dominant
Gelonade - hybrid sativa dominant

I also got Moringa Oleifera as a support supplement too. 500mg 3x a day.

So that's the idea. So with what I have research so far am I on the right path.

Any input and advance would be very much appreciated.

Awe
Coffeeshroom
 
Coffeeshroom said:
dose 200-400mg of Mescaline sulphate
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This is already more complicated than you need. If you have the HCL, why are you even looking at the sulfate potency, which just an FYI mescaline sulfate is almost always a mixture of mescaline monosulfate and mescaline hemisulfate, so dosage regarding sulfate really depends on the material and the pH at which it was salted.

You have the HCL which exists as a single molecule of mescaline to a single molecule of hydrochloric acid so there is no confusion.
Average dose of the HCL lets say 330mg. 330 x 5-10= 17-33mg.

17mg I would personally consider a complete waste of good material but that's just my opinion. Maybe, 33mg would have a noticeable effect, but if I was going to microdose mescaline I would probably aim for like 50mg. Again that's just me. Everyone is different and has to find their specific "microdose". Even 100mg I would find it very light.

Mescaline is kind of a strange substance IMO, in that it really takes me quite a lot to even begin to feel it, and then if I push dosage, the intensity becomes almost overwhelming. I believe my highest dose of the HCL was 666mg (lol I had 2x doses of 333mg that no one wanted to share w me so I took them both) I quit smoking tobacco that night for several years.
 
Shinji Ikari said:
I think I was dosing something like 40mg of HCl a day for a couple of weeks. I wrote it all down somewhere... I'll have a look tomorrow.

Tempted to revisit this, but mescaline is rare here and I only have a couple of grams (or less) on hand.
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Please do. Did you dose every day or take breaks, and guess i have to up my dose I can get another bottle or 2 of it, just bloody expensive for the hcl dropper concentrate. also my tolerance to psychedelics is low or is that not gonna matter here.

There is also a powder version that is a lot cheaper and comes in 5-10g batches. Will this be the suphate version of it @Didgital
 
Shinji Ikari said:
I think I was dosing something like 40mg of HCl a day for a couple of weeks. I wrote it all down somewhere... I'll have a look tomorrow.

Tempted to revisit this, but mescaline is rare here and I only have a couple of grams (or less) on hand.
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Assuming you can access Trichocereus cacti (they're sold at Home Depot and Lowe's here in the USA) you can just use vinegar and orange oil to extract mescaline acetate. I'm intending on trying to acquire a few hundred pounds of raw cactus to extract in a bathtub style to build a supply of mescaline that will hopefully last me a few years. It's trivial to grow fungi at that scale, but acquiring harmaline or mescaline at that rate is much trickier. Things that require synthesis as opposed to extraction I'm excluding from this pattern of thought.

Sorry if a bit goofy, just smoked amanita for the first time and it's nice.
 
I think 40 mg sounds about right for a minimal effect for most people. I don't really believe in microdosing, if for no other reason than there is absolutely no consistency whatsoever regarding recommendations I've seen. I'm also skeptical that sub-threshold doses even do much of anything. I assume that you either you take enough to feel it or you don't benefit. I do however think that semi-frequent "mini dosing", in which the aim is to achieve a minimal effect and no more, may be beneficial.

I would not take a psychedelic daily, and would not take them on two days in a row excepting occasional special circumstances like festivals or retreats. If one wishes to take minimal doses repeatedly, I suggest a dose frequency of once every 5-7 days and no more than once every 3 days. This is my suggestion in general, but I'm not at all familiar with microdosing as a strategy to ease symptoms of withdraw from other drugs. The thing is, it tends to be very difficult and not desirable to maintain primary psychedelic activity all the time (even at a minimal level). Fortunately, many beneficial effects of psychedelics overall last well beyond the primary effects, and if these post-trip effects help alleviate withdraw symptoms then one can probably get good results with the once every 5-7 days frequency I suggest above.

One other thing I'd say is that I think the post-trip effects get a lot better if one can increase the trip dose, but of course that means experiencing stronger effects. OTOH, the post-trip effects also last longer with bigger doses, so one can and probably should dose a bit less frequently. As such, the best dose likely depends on what one can physically and psychologically tolerate. I would definitely be wary about taking too much if in the midst of benzo withdraw. It's probably good to start at 40 mg or maybe even 20 mg to be sure you don't have any issues.

Whatever you choose, I hope it works out for you. Mescaline (in cacti) has always been a very special ally to me.
 
Cant remember where I was keeping track of my dosing... Might have been one of the DC daily threads but talk about looking for a needle in a haystack.

Well anyway, I was taking 40-50mg of synthetic HCl a day and it was a nice mood booster. Don't remember noticing much in the way of tolerance but as I said I lost my notes...

Acid is still my favourite psychedelic to microdose. 20ug always makes for a good and productive day but tolerance prevents daily dosing, every other day at best and even then I notice diminishing returns.
 
Shinji Ikari said:
Cant remember where I was keeping track of my dosing... Might have been one of the DC daily threads but talk about looking for a needle in a haystack.

Well anyway, I was taking 40-50mg of synthetic HCl a day and it was a nice mood booster. Don't remember noticing much in the way of tolerance but as I said I lost my notes...

Acid is still my favourite psychedelic to microdose. 20ug always makes for a good and productive day but tolerance prevents daily dosing, every other day at best and even then I notice diminishing returns.
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What was your dosing for Mescaline hcl, daily, any time off or how.
And how long did you use it. I ordered another 400mg, so now I will have 800mg total. Which makes fir a good 30-40mgs eod or e3d, I was thinking.
 
Shinji Ikari said:
Cant remember where I was keeping track of my dosing... Might have been one of the DC daily threads but talk about looking for a needle in a haystack.

Well anyway, I was taking 40-50mg of synthetic HCl a day and it was a nice mood booster. Don't remember noticing much in the way of tolerance but as I said I lost my notes...

Acid is still my favourite psychedelic to microdose. 20ug always makes for a good and productive day but tolerance prevents daily dosing, every other day at best and even then I notice diminishing returns.
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Allylescaline between 5-15mg daily has also produced no tolerance, but if I take 80mg+ I end up with a tolerance that lasts ~a week so. I need to test it with peyote, full spectrum Trichocereus extracts, and snow white mescaline at some point to see if the tetrahydroisoquinolines in peyote make a difference, or if the difference really is moreso to do with the other side of the phenethylamine SAR (towards the 4 position of the phenyl group).
 
Coffeeshroom said:
What was your dosing for Mescaline hcl, daily, any time off or how.
And how long did you use it. I ordered another 400mg, so now I will have 800mg total. Which makes fir a good 30-40mgs eod or e3d, I was thinking.
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Daily and for about 2 weeks. There probably were a few off days but I was taking it more days than not, 5 out of 7 maybe. I don't think there was any tolerance, but these are low and difficult to notice doses to begin with, and it was a year ago and my memory of the whole little experiment is hazy.
 
Esperighanto said:
I'm intending on trying to acquire a few hundred pounds of raw cactus to extract in a bathtub style to build a supply of mescaline that will hopefully last me a few years.
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this is hilarious and awesome to me. Youll want to invest in an industrial blender. I processed 100 kilos once from bouncing bear. I spent hundreds of dollars going though blenders until i wired up a kitchen sink garbage disposal. So satisfying to grind 3 foot pieces into powder.

and then the extraction... it was messy, ill never do it again.

That was the first mescaline I ever took.
 
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Didgital said:
this is hilarious and awesome to me. Youll want to invest in an industrial blender. I processed 100 kilos once from bouncing bear. I spent hundreds of dollars going though blenders until i wired up a kitchen sink garbage disposal. So satisfying to grind 3 foot pieces into powder.

and then the extraction... it was messy, ill never do it again.

That was the first mescaline I ever took.
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I saw a photo essay once where this guy went through three garbage disposals trying to bulk process cactus, I've honestly considered going as far as just using power tools to grind it by hand if industrial blenders and garbage disposals fail me.

It's good to hear that others have done the, I cannot imagine the cactus-y smell that has to permeate the entire area. Can't wait 😈.
 
Update here.

I got another 400mg 30ml dropper bottle. So have 800mg Mescaline hcl and seeing its 13.3mg per dose and regardless of what most microdosing regimes suggest, when it comes to Mesc, a higher dose is needed.

So with all that said. I'm going with a 3ml microdose =39mg Mescaline e3rd day. My first dose will be 1ml and 2nd 2ml and 3rd 3ml. Reason is I want to see with the increase how closer I'm to the full psychedelic interactions as I increase. Who knows maybe I will push it up to 4ml = 52mg Mescaline hcl.

And so far I worked out this regime with input from my fellow bluelighters, some external research and overall personal exp from most ppl and them working out the common denominator when it comes to dosing which is 30-50mg for microdising.

I'm still recovering from a flu and self induced suffering but hope to start next week.

So just a recap, this is what I feel I want to fellow as my regime to microdose this.
Day 1 = 1ml = 13.3mg
Day 4 = 2ml = 26.6mg
Day 7 = 3ml = 39.9mg
Then continue with 3ml e3rd.
Off days I boost my thc intake and on days lower thc dose. These are the concentrates, like RSO oil.

I also have some botanical extracts too, pink lotus, blue lotus, sceletium tortuosum and Silene capensis aka african dream root..

But that for later.

Thanks for the input and help so far
 
Coffeeshroom said:
Update here.

I got another 400mg 30ml dropper bottle. So have 800mg Mescaline hcl and seeing its 13.3mg per dose and regardless of what most microdosing regimes suggest, when it comes to Mesc, a higher dose is needed.

So with all that said. I'm going with a 3ml microdose =39mg Mescaline e3rd day. My first dose will be 1ml and 2nd 2ml and 3rd 3ml. Reason is I want to see with the increase how closer I'm to the full psychedelic interactions as I increase. Who knows maybe I will push it up to 4ml = 52mg Mescaline hcl.

And so far I worked out this regime with input from my fellow bluelighters, some external research and overall personal exp from most ppl and them working out the common denominator when it comes to dosing which is 30-50mg for microdising.

I'm still recovering from a flu and self induced suffering but hope to start next week.

So just a recap, this is what I feel I want to fellow as my regime to microdose this.
Day 1 = 1ml = 13.3mg
Day 4 = 2ml = 26.6mg
Day 7 = 3ml = 39.9mg
Then continue with 3ml e3rd.
Off days I boost my thc intake and on days lower thc dose. These are the concentrates, like RSO oil.

I also have some botanical extracts too, pink lotus, blue lotus, sceletium tortuosum and Silene capensis aka african dream root..

But that for later.

Thanks for the input and help so far
Click to expand...
Let us know how this goes! Mescaline microdosing is still wildly underexplored, really any phenethylamine based microdosing seems to be so far. 2C-B and mescaline are likely the two most accessible for people, and therefore the two most valuable to figure out microdosing strategies for. I was microdosing DOB (325ug every 3 days), but then dropped a monster NBXX dose that fucked my tolerance all up, so I'll give it another couple weeks for my tolerance to reset before hopping back on the microdosing DOB train. I felt acute effects from even that one dose I took at 325ug though, which was shocking because I found threshold to be maybe 100-200ug (tough to cut a 750ug tab that small), but it still felt like threshold at 325ug as well. DOB is the strongest DOx I've interfaced with so far, anything over 3.5-4mg feels like it's going to stop my heart. Might be the only psychedelic I've decided "eh, it's benzo time now" within just the first few hours.
 
Okay well plans are to start next week.
Thinking a multi vitamin and some sceletium. But will see got 6 days to workout the full program and all meds and so on that's gonna be used.

But looking obviously at the Mescaline hcl dose.
During this time try and lower methadone dose and maybe drop my diazepam with another 5mg thar will give me a total of 10mg a day.

Anyone that knows my past use with what I'm doing today is day and night...
I had some shrooms like 14 days ago and this weekend mostly alcohol. So this week keep clean with just the minimum maintenance dose and weed nothing else.

Awe
 
Okay do with all this d
Said I got 800mg mesc hcl, and decided to dose at 40mg and maybe up if needed. And then 50mg thc conc, on off and 75-100mg thc on off days.
Total run time is gona be a month and a half.

So 13mgx3= 39mg pera dos3 and gonna go 3rd and after that maybe push it up to 52-78mg if needed but we will see.
 
I am not a microdosing person. Although pure mescaline is my favorite psychedelic, just a little behind LSD. In some ways LSD is superior but the side effect of neural overload or dopaminergic effect waking up still tired and exhausted I give the edge to mescaline. nn-DMT has it's special place but it's not a total reset of a long experience. 2C-B is special too not for an ego-death experience because in higher doses the bodyload and some noise becomes disturbing.

I have the most experience with mexican cubensis but they always give a fog and I really have to work hard to stay positive and not go negative because of confusion, even with Hawaiiens which are superiour. With LSD and Mescaline there are some difficult moments too sometimes but it seems easier to stir away without so much effort and stay positive when going towards a full egodeath experience. If I am going to have a trip, and I take long serious one I would choose between LSD or Mescaline anytime over mushrooms

I don't like to eat whole cactus or snoth tea as it more difficult to digest and harder on the stomach. The nausea of drinking it in a cup of water over 30 minutes is minimal to non-excistent.
Difficult to explain, just my two cents.

Anyway a bit off topic, just to explain what's on my menu and past experiences and how and why I compare them relatively.

On topic:
On the Vespiary someone commentated that he finds mescaline not suitable for microdosing as it tends to give migraines. Found that interesting (Don't know which form, I always take the sulphate for a full dose, don't think it matters much I assume?)

Now I don't know if this true or relevant and why this would only be true for mescaline. But one thing I can think of is that Phenylethylamines can have more interferance then Tryptamines, or maybe psychedelics that has as a MAOi effect with alcohol, MDMA, Amphetamines, or a certain diet (don't know if this true in this situation) making these less suitable for microdosing in general or in particular situations.
 
Microdosing mushrooms is no longer the best-kept secret in psychedelics.

Low doses of San Pedro, combined with breathwork, cold plunges, and somatic work, has taken the crown.

Psilocybin has the hype, but the cactus is smoother, stronger, and better for nervous system healing.

PaulAustin3w, 2025-07-10, twitter
 
Weird concept. I cannot imagine any dose below tripping levels would be worthwhile, I get pretty horrific GI discomfort from any and all serotonin modulation. Nowadays I just dose pretty high with any psych and heap benzos, opiates, and alcohol on top with some ondansetron set aside for real bad cramping.

Seems a waste of good mescaline to me but if you wana experiment, hope it works out well for you. I've just always seen microdosing as a misguided attempt to replace anti-depressant drugs which are already a hoax in their own right *shrugs*
 
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