Cool just logged on and figured the thread might have gone dead. I was actually fortunate enough to converse with one of the top science guys from the company - make of this what you will but i thought i should put that out there that it wasnt' an independent source. However I know my science (though i'm no where near the finished article i'll happily admit) and like to think i can tell when I'm talking with someone who knows their stuff, at least that's how i feel. Anyway, I was first concerned about pmma / pma. My concern was in reference to deaths from pills containing pma or pmma in them instead of mdma, and since all i remembered was the para methoxy group i immdediately raised a flag for concern. However, it appears that the toxicity from these compounds comes from the fact that they are both monoamine releasers and oxidase inhibitors simutlaneously. This is a minor concern for standard amphetamine (base, speed) and no concern at all for mdma, which explains why mdma has a better safety profile than speed. Anyway, what it means for something like pmma to be both a releaser and an oxidase inhibitor (non selective too, meaning serotonin, dompamine and noradrenaline) is that the drug not only stimulates neurons to increase their release of these transmitters, but also binds to the enzymes responsible for breaking down these neuro transmitters. This essentially means you are burning the candle at both ends so to speak, or to use more technical terminology, the dose repsonse curve is fucking steep. A similar effect occurs with alcohol, though by quite different mechanism. Anyway, the chemist in me can see why pmma can posess this unfortunate quality. The more simple the molecule, the more likely it is to bind to multiple targets. Unfortunately, the combination of a simple yet ultra potent methamphatamine side chain coupled to a para methoxy group is perfect for fulfilling both these tasks. The reason it does this is that it is so similar to monoamines like serotonin that it fools the enzyme responsible for breaking serotonin down into thinking it is serotonin. This means the enzyme can't do its job on the real serotonin. The para methoxy group proabably means that it binds to the enzyme with greater affinity than base amphetamine - though I don't know that this is the exact reason. These things nearly always come down to timing. When a drug binds to a receptor it may only be for a millionth of a second. The fact that there are many trillions of the tiny drug molecules in your brain is what enables binding on such tiny time scale to actually bring about a major change in perception ie. get you high. I could go on all night but I'll refrain unless anyone has any specifics. Or like i always, say, someone with better knowledge can step in and further what i've said, or correct errors.
Now, looking at the MEOP molecule, i can say how this crazy looking ring system with the amine in the 4 position actually helps prevent MEOP from being toxic, certainly in the manner described just now. Its such a crazy take on a phenethylamine (speed, mdma, mescaline even are all phenethylamines). The trouble is it is a little too good at this for its own good, and may therefore not be active on its own. Today, for instance, I took 55mg of MEOP and only 35mg MTTA, and even this slight drop off in the ration of mttp seemed to hamper the activity of the MEOP. I have yet to take MEOP on its own. Like i said i have just started on an extensive research quest that is of huge interest to myself, even if no one else, though i suspect this won't be the case, however it depends what you're looking for. I'll go into that in just a moment. I want to urge a little caution at this stage with combining MTTA on its own with other drugs, especially in high doses. Since i think it plays the role of propping open a receptor, or something along those lines, i think that it can be dangerous with other serotonin agonists..maybe. Its just that i've tried mtta alone and got no results. I've tried it with pure opiods like AH 7917 (is that right - the codeine, morphine thing) and found no bad interactions. However, I thought i maybe sensed a bit of overload when i tried it with tramadaol - something that has both opiate and serotonergic activity.
I like the combo. Strikes me as a real user friendly stim to take in the day time, at 100mg doses, 50 of each. I recall taking a 150 mg 75 each combo previously and maybe getting into slightly rushy territory but i'd like to revisit this again myself before anyone goes out and buys it expecting to achieve euphoric affects at these doses. What I been getting from it at around the 100 mg 50 50 combo range is what i can best describe as clean energy. Its sort of like a half way house between lighter stims like ethyl phenidate, adderall etc.. and something a little heavier like mpa. So, to be put on the spot, for me with my tolerance £20 for half a gram of each gives me 10 doses. I'm real big on my functional stimulants - ones i can use in the day just to get me going and being productive. If you have a high tolerance relative to me, then maybe you may find you need twice as much and so at £4 a dose it may not seem like money well spent.
I gotta get some sleep now as i have to be up real early to meet with a union rep to try and save my shitty job that i fucking hate anyway so i'm gonna have to do one. Sorry i didn't get round to saying why I'm looking at mtta in a totally different way. Anyway, I'm a stamp collector if there ever was one when it comes to RC's or any other compounds. I even take shit i don't enjoy - like diphenhydramine, and some scopolamine relatives as I am totally obsessed with acetylcholine. So rest assured i'm gonna investigate these things from all angles, as i do with everything else - now i got it as safe in my own head. Anyway, glad to see the thread hasn't died. Peace.
