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Mephedrone and Serotonin Syndrome

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Falcon0r

Bluelighter
Joined
Jan 22, 2008
Messages
132
I don't know much about Serotonin Syndrome aside from what I can understand from the wiki page without much pharmacology knowledge.

Recently, a group has been doing Mephedrone a lot. I see the doses people talk about on this site, and it is much less than that. It would be about 100mg taken orally, and then a couple bumps/lines. Enough to get droned out as hell, but really in reality and comparison to others, it's not that much.

This will happen about two to three times a week.

Are we at risk of serotonin syndrome? One person IS on SSRIs, I am not sure which. This group does cocaine too frequently, but never together (Except once, it was alright.)

Should we be taking breaks to let ourselves recover? Any suggestions on safety? Getting a little concerned since summer is coming and that just means there will be more and more.
 
i'd not be worried about serotonin syndrome as that is an acute condition and usually only occurs with combinations of serotonin releasing / mao inhibiting / otherwise raising the concentration of serotonin substances. i'd be much more worried about causing unwanted regulation mechanisms in the serotonin system which can lead to depression, anxiety and lots of other ugly conditions. in general as mephedrone most likely has the same or a very similar mechanism of action as mdma and the recommended intervall between dosing mdma is about 2 months i'd never take mephedrone that often. i'd be even more careful with it than with mdma as meph isn't that well researched.

there also the issue of possible neurotoxicity. imo there's no need to worry when taking mdma in reasonable doses, but as so little is known about mephedrone i can't rule out neurotoxicity (like you have with most 4-halo amphetamines).

the bottom line is: we have no idea how toxic mephedrone really is, but i wouldn't want to take those risks.
 
mephedrone is wayyy weaker than mdma, and i think personally acts more like citalopram but do farr less if on ssris, and the recovery period is much smaller. serotonin syndrome is not the main worry. i'd be more worried about the use of coke and the fact that both these stimulants by definition are overabusing your hearts. you need to remember that a heart is for life and when it goes so do you!
 
strattera69 said:
mephedrone is a derivative of methcathinone, an euphoric stimulant.
reports make it sound highly addictive ala cocaine. Probably not
worth using from a financial standpoint.
Click to expand...

You're saying that financially it isn't worth it to use Mephedrone? It runs for about half the price of cocaine in my area gram for gram.
 
It is addictive for sure, as are practically all stimulants. The comment is of rhetorical nature IMHO. And from a purely financial standpoint, it IS worth the effort: It costs less (half of coke's price is a bit expensive, but anyway...) and the effects last longer. If the quality of the high is comparable...well...that's a different issue.

- Murphy
 
Falcon0r said:
You're saying that financially it isn't worth it to use Mephedrone? It runs for about half the price of cocaine in my area gram for gram.
Click to expand...

you could say the same thing about methamphetamine in turns of price and
length of effect...the fact the drug just takes longer to drain your pockets
doesn't make it desirable in my eyes; anything that makes you feel compelled
to trade your money and possessions away for a short-lived feeling is the
thing to be avoided if you're wise inside.
 
Please use the large and nifty thread in the future for simple drug interactions. As far as I know there hasn't been a formal investigation of the 5HT releasing/reuptake inhibiting properties of 'mephedrone', so it's difficult to really answer this.
 
Word on the street is that it has a very likely potential to be cardiotoxic due to 5ht2b agonism. You are putting your heart at a great deal of risk using this substance at all, and much more so in the dosages/frequency you are consuming. Be smart and lay off this one until a bit more is known, personally I would not touch it with a ten foot pole, seems to be the most potentially toxic RC out yet. Also there is already at least 1 documented death due to mephedrone so tread lightly.
 
theWorldWithin said:
Word on the street is that it has a very likely potential to be cardiotoxic due to 5ht2b agonism. You are putting your heart at a great deal of risk using this substance at all, and much more so in the dosages/frequency you are consuming. Be smart and lay off this one until a bit more is known, personally I would not touch it with a ten foot pole, seems to be the most potentially toxic RC out yet. Also there is already at least 1 documented death due to mephedrone so tread lightly.
Click to expand...

by word on "the street" you mean a couple of people on bluelight from a while ago. in reality you seem to imply that this assumption is almost true but in reality none of us have a clue. as with every research chemical it is a risk we take. the same can be said about MDMA for an actual fact but the problems with that dangerous effect will result from very regular use. people are more likely to experience tachychardia and panic if their heart rate goes up when reading overzealous attempts to "know" about the unkown which may create a panic attack. if it is THAT dangerous creating panic could only heighten the problems you are attempting to prevent from occuring. it needs to be tested rigorously in a large scale study but unfortuantely no-one wants to alert the authorities so we are the guinea pigs. as for averting someone from being a guinea pig for anything your advice is sound. amt has killed so has e so has coke heroin so has speed so has cigarettes: in other words the logic is not good. many people have idiosyncratic reactions to things and drop dead, one death alone can teach us just a very little amount of info.


the biggest issue with this drug is its intensely compulsive nature and relaxing chilled head space as a combo of effects that lead to a lack in hram reduction behaviours.

all hard stimulants are undesirable for your heart
 
I forgot if it was BL or another forum I post on that doesn't allow discussion of prices so I won't go into specifics on that but if anyone has seen it at "stores" then they would know too. I am by no means using its affordability to justify using it all the time. I have kicked some sense into the others in my group and we are at least trying to take week long breaks in between use, and the amount consumed has gone down significantly due to not having time really.

I thought the JWH compounds were the only ones that were actually considered to be dangerous, rather than "It might be dangerous"?

And of course it is bad on your heart and body as a whole with it being a stimulant, I was more concerned with it's damage on the gear upstairs in the noggin.

I like to think that between under-researched RCs and intravenous drug use, I like to keep myself as safe as possible.
 
i feel SSRI's and taking other drugs is just retarded since it usually dampens the effects hardXcore or blurr's them out entirely. She/he is probably getting some dose of placebo though, like if they take MDMA do they act high?
 
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