N&PD Moderators: Skorpio
Meo-b?
So along with a recently received order of GBL i got a 250mg sample of something called MEO-B. No CAS# on the bag or site. There is the molecule below if anyone can tell anything from it. This is the more correct name but i'm not even sure if it's just polish or whatnot 1-(4-metoksyfenylo)-2-(metyloamino)butan-1-on
Any help would be appreciated 
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Deleted member 170540
Bluelight Crew
Those para-methoxyamphetamines tend to cause a dangerous rise in blood pressure, but no recreational effects...
sekio
Bluelight Crew
It's para-methoxy butylone. As polymath stated there's a good chance it will be rather ridden with side effects.
indelibleface
Bluelight Crew
Morbid sense of humor with the brand name of the drug, there.
MEO-B...MAO-B?
Might as well call it HYPERPYREXIC CENTRAL NERVOUS SYSTEM APOCALYPSE, although, clearly, that`s neither as catchy, sexy, or marketable.
Swerlz
Bluelight Crew
flush it
avoid para- MeO like the plague
amanitadine
Bluelighter
^^^ True True, but I will admit to having a handful of enjoyable (if unremarkable) experiences with PMMA years ago. People respond quite variably (pleasant euphoria <> death) to 4-MeO. There was a handful of people at the time experimenting with anethole and its derivatives, and there was little in terms of a uniform experience. A Very narrow therapeutic index ....I had nice serotonergic effects from 100mg whereas someone else had a pretty toxic reaction from 150mg. Whoever opted to put it (and PMA) into distribution was beyond idiotic. I think there were some recent deaths from PMMA in Norway or Sweden, and I've noticed several vendors stocking bk-PMMA. Crazy.
Limpet_Chicken
Bluelighter
Shulgin seemed rather to like the PMA, although warned of deaths, never tasted either PMA, PMMA or the beta-C=O derivatives myself, meph/methedrone both look plain fucking ugly as shit, if you choose to take it, work your way up from I would say, no more than 10mg, after a preliminary allergy test.
The butanamines appear by weight to be weaker than the corresponding phenisopropylamine (not speaking specifically for the para-OCH3), and as there is a significant chance that much of the toxicity of mephedrone and its nastier little friend methedrone is in a large part coming from its metabolic degredation to the corresponding ephedrine, and in the case of the methoxy compound, aromatic ether cleavage to the 4-OH ephedrine which appear to be quite potent vasoconstrictors (amongst possible other, less pleasant effects still, such as those reports of persistent circulatory and heart issues)
PMA has a very steep dose-response curve, not so sure about the secondary amine (PMMA) in comparison, but the beta-keto-2-aminobutane is going to be less potent by weight than either PMA or PMMA, or mephedrone/methedrone, and I believe thus, given the strong reinforcing properties of the latter two and how likely this is to be taken in repeated doses, compulsively amongst many users, it will display a strong increase in potential for toxic responses or deaths, due to the corresponding increase in levels of the ephedrine-like metabolites.
IIRC, although again I have never tried it, buphedrone and butylone have more adrenergic effects than the amphetamine counterpart also, so doubly nasty if this is so.
Jamshyd
Bluelight Crew
OP: Was the first sentence of your post really necessary? What information does it contribute that prompted you to decide it was important enough to include?
I guess with the wealth of side effect warnings so far along with my rather serious hypertension, means i will have to flush the shite after all. Maybe someone in the near future who isn't as sensitive as myself will get a chance to do a trip report
AndroidsDreamofBTC
Bluelight Crew
I'd just like to post a quick trip report about this substance combined with some piperzines. I got this as freebie from an online vendor.
This was what was written on the "Material Safety Data Sheet":
Trade Name: 1-(4-metoksyenylo)-2-(metyloamino)butan-1-on + LAB-X 3:1 (meopp+pfpp) (70%+30%)
Of course, the vendor didn't provide a CAS number.
So basically this was 200mg of powder of the following:
140 mg Meo-B
45 mg meopp
15 mg pfpp
From my research, I found that the dosage for the pipes was relatively low and shouldn't cause typical piperzine side effects.
T+0:00
As Meo-B seems to be related to the PMA series, I decided to start with a low dose of 50 mg and see how long the come up would take.
T+0:30
This initial dose kicked in within 30 minutes or so. This was a good sign as I read that the PMA series are supposed to have a rather long come up. The initial effects were mildly speedy. I was playing some TF2 and I was getting really into it. I would compare it taking 10 mg of amp with moderate tolerance. My mouth is quite dry and I am constantly sipping on water from my glass.
T+0:50
I am not sure if this feels very different to regular amp even with the pipes thrown in the mix. For some reason I am getting a little bit of anxiety at this point - but that could be just because I ingested an unknown substance that very few people have tried. But the anxiety quickly subsides. At this point I decide to take another 50 mg. I also get another glass of water.
T+1:20
TF2 is still going really well, the extra 50 mg added a nice boost to the amp like effects. I feel some mild DA style euphoria, nothing special. Meo-B definitely feels like a pro-sexual drug (similar to amp). I decide to put on some Trance music, as I usually enjoy listening to EDM when on amp-like drugs. Music sounds pretty awesome.
T+2:00
The amp like effects are starting to subside a bit, so I ingest another 50 mg. TF2 is still going very good. Still experiencing the amp-like alertness, mild euphoria and such. Smoking a cig feel really good. I am still constantly sipping on water.
T+2:40
I eat the remaining 50 mg to keep myself on my current level.
T+3:30
The effects are definitely starting to subside. However, I don't really feel burnt out like I do after ingesting high doses of speed. The comedown seems pretty mild.
I didn't have much trouble going to sleep in 2 hours or so. The next day I had to go to work and I didn't notice any side effects at all.
Overall, I would say Meo-B feels like weak amp with less of a comedown. I see no point in messing around with this substance if you can get regular amp.
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sekio
Bluelight Crew
You are a brave, brave man. Much braver than I.
I think this subatsnce should be confined to the garbage can.
ebola?
Bluelight Crew
We could further explore this:
it seems that elongated alpha chains on beta-ketone subbed amphetamines confer activity as NDRIs rather than monoaminergic release. Given this, how should we expect the 4-methoxy substitution to modify activity differently?
ebola
sekio
Bluelight Crew
Assuming a SAR model closer to that of pyrovalrones, 4-methoxy is much inferior to 4-methyl in terms of potency. it is, however, slightly more slective for the DAT.
Better still would be a 4-acetylamido group. It's the most selective for DAT, from what I'm reading. 4-propynyl is good too.
Hammilton
Bluelighter
The question is whether the 4-methoxy inhibits MAO. I can't think of a reason to think that it won't.
DARIs and Releasers are both dangerous in combination with MAOIs.
sekio
Bluelight Crew
Yes, the 4-methoxy cathinones still inhibit MAO-A. They are much less active than amphetamine, however, and 100fold less active than the comparable amphetamines. Even the 4-alkylthio cathinones have EC50s above amphetamine. The longer 4-alkylchalcogen chains (4-propoxy, 4-propylthio, etc) inhibit MAO-B, however.
It's interesting to note that the norephedrine metabolites are also MAO-A inhibitors with strength comparable to amphetamine.
(source: M. Osorio-Olivares et al. / Bioorg. Med. Chem. 12 (2004) 4055–4066)
