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  • Trip Reports Moderator: Cheshire_Kat

Memantine (225mg) - Experienced - This time I took way too much memantine

psilocybinsane

Bluelighter
Joined
Nov 29, 2010
Messages
146
Location
The city that never sleeps...
Age: 26, Weight: 140lbs
Dose: 150mg oral + 75mg oral redose at around T-09:15

My intentions with this experience are: to explore this compound further (in ascending dosages), to help me gain some insight into some current predicaments in my life, and also to take a nice mental vacation. I don't always go into dissociative trips with rigid intentions, but it seemed right today so I'm going with it. I have taken memantine at recreational doses 7 times prior to this, and it has been quite a nice dissociative with a unique, introspective headspace and it even helped to pull me out of a depressive episode that I had been in previously. Although there are better dissos out there, this one's still pretty cool in its own way.

08/02/18 @ 10:37am: Memantine hcl (powder), 150mg orally consumed on empty stomach. Disposition is good. I'm excited for this trip and I am just killing time. I am going to clean up my room a little bit before I start to come up.

11:40am - Starting to get my first alert, which is some mild stimulation and euphoria. Whenever I've taken more than around 60-80mg, I end up feeling an alert 30-45 min in, but it never fully manifests itself until after 2-3 hours have passed. I'm sure this is going to be a more intense experience at this dose, and I'm very excited to find out if it will get more visual. I'm hoping it will behave more like the more well known dissos at this dose (PCP, Ketamine, etc) but that may just be wishful thinking due to memantines NMDAR affinity and binding kinetics.

12:55pm - Now, as I'm starting to come up even more, and starting to dissociate, my dad remembers that we have a few errands to run! So much for a carefully planned trip, I'm not trying to let this bother me, but it does kinda suck. I'm sure I can maintain well enough, but I'm already starting to have a little confusion and it's only going to get more intense from here. I will just have to bite the bullet and hope this does not take too long. For context purposes my dad does know about my drug use and he's even cool with certain things too. I just hate having to walk around in public dissociated or tripping. It gives me anxiety...

4:25pm - Thank goodness it's finally over! Being out in public while I came up on this experience was just too much. My mental state grew more and more anxious and paranoid the higher I got, and it just kept getting more intense. I stumbled every so often, and realized how weird I must've looked just kinda following my dad around these different stores like a lost puppy. And it felt like it took for fucking ever too! I was experiencing some major time dilation though because we were only gone for around 3.5 hours. But rest assured, it felt like a god damn eternity lolol.

But I survived, and now I'm feeling much better now that I have a chance to sit down and relax. I started to enjoy the effects a lot more while we were on our way back. I was listening to a psy trance playlist that I've heard many times before but I was marveling at just how different it sounded then: tinny, and almost far away. Also I keep getting a distortion that sounds like the song is playing slightly slower than normal. This has been a pretty awesome, euphoric peak, but really it doesn't seem all that much stronger than some of my previous 100mg doses. Maybe tolerance is a factor, either way, I'm having a blast. Going to switch to my Dubstep playlist now.

6:47pm I had some bad urinary retention a few minutes ago. I have yet to experience urinary retention from memantine, but I have had it from other dissos (DXM and Ketamine being the worst culprits I can think of). I think I want to go deeper into this experience, so I'm thinking about weighing out a redose.
It's not that the effects aren't there, they are, but not much more than they were at 100mg. I'm thinking tolerance is what is causing this, so taking a little bit more to compensate should be just fine. I am loving this right now, so, let's do this!

7:52pm Orally redose 75mg memantine (total: 225mg, holy shit lol that's a lot) on an empty (still) stomach. I know I need to eat now so I'm going to make something after typing up this entry. I'm enjoying this dissociative headspace, but I'm ready to go deeper! I hope it will be a visual experience (I plan on laying in a completely darkened room on my comfy bed when the second capsule kicks in), but either way, it is and will be amazing! I'm feeling very strong euphoria right now that makes for some wicked music enhancement (The kind that makes my body hair stand on end). Hopefully if all goes to plan I myself will become an explosion of bliss and love that will transcend my body before being smeared across the backdrop of the universe.

This headspace is quite trippy!

11:45pm - I'm ready. Wow! Access denied says the brain to the body. This is going to be one for the books. I wonder if anyone has ever taken this much memantine with the intention of tripping... 225mg? I somehow doubt it.

I am losing the plot.

This song is pulling me in. So I've got to get up and turn out the light so it can do it's bidding. I will update you all when I return. Unless I don't return (just kidding XD) Things are going great so far! I feel like I'm rambling nonsense. Manic, psychedelic, stroboscopic. Stop motion flanging. Gone...

2:38am - Oh my, that was *quite* trippy! Even after that high of a dose, it's clear that memantine is a cool drug, and it's a disociative yeah, but not a dissociative anesthetic. I don't feel like I could breakthrough with this stuff (although I was trying to), but that's ok. Every drug has its own flavor. But it has been so fucking intense and immersive still, also with a lot of confusion. The ability to function normally comes and goes at this dose. I'm not sure if the happiness I'm feeling is euphoria, or mania. Maybe they are the same thing? Either way this is super intense. The visual distortions have been cool, and there has been some auditory distortions as well as everything sounding either far away, or really close to my ears. I can't keep a train of thought and literally feel braindead at times lol. I'm going to go smoke a bowl of cannabis and then lay down and meditate in my darkened room...

10:49am (08/03/18, the next day) - Slowly coming back to consciousness. I got so deep into the meditation that I actually slipped away fully into unconsciousness, but it's no big deal because I'm still dissociated, ahs feeling good to boot! I'm slightly groggy, but it feels so good to be alive.

I'm still really altered, and I suspect I'm operating on autopilot. I've been concious for around a half of an hour, but I don't really feel conscious. My cognitive condition is smeared across the trippy memories of the last 24 hours. Wow it feels like it's been longer than that! Still very euphoric/manic. The experience I had last night in my room was great! Not quite as visual as some of the other dissos I've done, but awesome nonetheless.

Me and my roommates are going to taco bell, what a great idea!

2:51pm - I'm back from taco bell, and although I'm not antwhere near baseline yet, I'm really tired. Also I must not be as anesthetized as last night because my body is quite sore. So, my plan is to smoke some more killer cannabis and pass the fuck out. Good night world.

(08/04/18, 9:30am) - I slept for way too long, and I'm still not at baseline yet. Definitely closer than yesterday which is nice, but still. I kind of want normalcy at this point. I feel like I've been on a massive journey, but now have made it home triumphantly. There is a nice subtle euphoria still as well. This feels similar in some ways to a MDMA afterglow. I feel at peace with myself and the world and ponder on how much these tools have helped me. That therapeutic potential is what always draws me back to psychedelics, dissociatives, and empathogens/entactogens.

6:02pm Having a lot of premature ventricular contractions (a type of heart arrhythmia that feels like fluttering instead of a normal heart beat) and it is a little strange for sure because they are happening very frequently. I know that memantine has 5-HT3 antagonist properties and that makes me feel foolish for taking that high of a dose. 5-HT3 antagonists have been implicated as being a cause of Prolonged Q.T. Syndrome (a cardiovascular condition involving the electrical systems of the heart) and that's something I definitely don't want.

With memantines odd pharmacological profile I should've known better than to take that much. I have learned another important lesson about respecting these substances (especially ones without much history of recreational use). I need to get a cardiovascular work up done anyway because I've abused my heart a lot (Recovering IV heroin addict that injected all sorts of nasty stuff in 8 years of use. Thank God for Suboxone). If I ever do use memantine again, I will only do so after a cardiologist has given me a clean bill of health, and I will limit myself to 100mg. At that dosage level, I had no worrying side effects, and the experience was still rather nice at that dose as well.

(08/05/18, 9:25am) - I'm happy to report that I've finally reached baseline. As per usual, I'm left in a nice afterglow. My heart also feels much better and I'm no longer having any arrhythmias. I learned a valuable lesson about setting realistic limits while conducting research so that my delusions of sobriety won't convince me to take more of whatever I'm researching. Now that I'm sober again I can see how reckless it was redose like I did; 225mg of memantine is just way too much. The 3 day trip that ensued was pretty cool, but dedinitely not cool enough to keep researching. Time to move on to the heavier artillery. More trip reports to come XD

I do feel memantine has antidepressant potential if used properly. That said, I personally feel that with memantines pharmacology, and after my experiences with it that it isn't capable of causing breakthrough dissociative experiences. It does however, have some awesome effects at the 50-100 mg range that are definitely worth checking out if you like dissociatives and your tolerance isn't super high.

This exeperience had it's good points and bad points, but overall it was a beautiful experience that has left me feeling happier and more content and that is a beautiful thing. I'm going to stop rambling now. I hope you all had a good night!

Namaste.

Tagged by Xorkoth
substancecode_memantine
substancecode_dissociatives
explevel_experienced
exptype_positive
exptype_healthissues
exptype_overdose
roacode_oral
 
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I can't wait to try this. I wonder if my psychiatrist would give it to me. I do have depression and social anxiety and haven't had much luck in the medication department as far as the anxiety goes. I also have mild memory problems which it might aid. When I asked my doctor she told me she would rather not give it to me since I don't have Alzheimer's.

Does memantine work on a full/semi-full stomach?
 
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