melatonin with mao-a inhibitor

[melange]

What would happen if you took melatonin with a mao-a inhibitor.


I know mao-a is responsible for the breakdown of melatonin.

I assume you would just get effects similar if you had taken melatonin or a m1/m2 agonist.(duh?)

 

[Temeraroius]

Ive heard that melatonin gets metabolized into DMT to a certain extent, perhaps an mao-a inducer would be more interesting? Though I know mao-a would probably break down DMT so who knows.

 

[b4rd]

Yea, the effective dosage of melatonin is wayyyyyy lower than what is given out in the supplements. So, in reality, more melatonin does not make you more tired. There is a cuttoff for increased dosages, and it is very low.

But if you have too much, you may not be able to sleep

Just take the 1mg or the 3mg melatonin, thats all you need.

 

[MeDieViL]

Melatonin is NOT metabolized by MAOA, however MAOA inhibits the synthesis of melatonin, so inhibiting MAOA raises melatonin.

 

[hamhurricane]

i have done this numerous times, most days i take a combination of moclobemide and selegiline (150mg and 5mg respectively) and i take 3mg of melatonin each night - there is no psychedelic effect or noticeable potentiation, although i was not really looking for it - there is an erowid report for high dose melatonin and moclobemide in which the user reports unusually vivid dreams.

 

[Temeraroius]

OP, is there a specific effect you are trying to achieve? Increased sleepiness or increased dreaming?