[Mega] Opioids (codeine, hydrocodone, oxycodone, heroin, etc.) and Ecstasy

[VelocideX]

Be very carefull, according to the MIMS, basically the drug information book for docs/nurses/pharms, tramadol is actually an MAOI, MAOI+MDxx=dangerous, and MAOI's can be dangerous even after their halflife has expired

Really? I can't find that anywhere in MIMS.

Contraindications: Intoxication with alcohol, hypnotics, analgesics, opioids, psychotropics; MAOIs (concurrent or in the previous 14 days); not for use in narcotic withdrawal; opioid sensitivity; pregnancy

Drug Interactions: MAOIs (see Contra); CNS depressants incl anaesthetics, alcohol; mixed opiate agonists/ antagonists eg buprenorphine, pentazocine; drugs which lower seizure threshold eg SSRIs, TCAs, antipsychotics; carbamazepine; quinidine; ketoconazole, erythromycin; drugs that increase serotonin; coumarin derivatives

Tramadol is a centrally acting synthetic analgesic of the aminocyclohexanol group with opioid-like effects. It is not derived from natural sources, nor is it chemically related to opiates.

Pharmacology. Although preclinical testing has not completely explained the mode of action, at least two complementary mechanisms appear applicable: binding to mu-opioid receptors and inhibition of reuptake of noradrenaline and serotonin. The opioid-like activity of tramadol derives from low affinity binding of the parent compound to mu-opioid receptors and higher affinity binding of the principal active metabolite, mono O-desmethyltramadol, denoted M1, to mu-opioid receptors. In animal models, M1 is up to six times more potent than tramadol in producing analgesia and 200 times more potent in mu-opioid binding. The contribution of tramadol to human analgesia, relative to M1, is unknown.

Both human and animal studies have shown that antinociception induced by tramadol is only partially antagonised by the opiate antagonist naloxone. In addition, tramadol has been shown to inhibit reuptake of noradrenaline and serotonin in vitro, as have some other opioid analgesics. These latter mechanisms may contribute independently to the overall analgesic profile of tramadol.

 

[Neophyte]

I apologise for the misinformation, I misread.

 

[shubs]

so SSRI's "build up" in your brain somehow? Taking the tramadol at 200-250mg doses twice a week should not completely nullify the effects of MDMA? is it possible I get about 75% of the mileage out of the bean if I wait about 72-96 hours to take the bean? and then after 1 week plus I should be all clear? Since I only took ultram 6 times.

 

[Infinite Jest]

Tramadol's a pain killer. See Erowid.

Apparently Tramadol may react with SSRI's. It also has SSRI properties: "it inhibits the re-uptake of noradrenaline and serotonin" (from the second link).

"ADRAC advises that caution should be taken with the use of high doses of tramadol and with tramadol in patients taking medications known to increase brain concentrations of serotonin."

I would assume that MDMA would be included in the category of "[substances] known to increase brain concentrations of serotonin".

So clearly you shouldn't take them together, and the issue becomes how far apart you should take them to be safe.

(by coincidence I took some recreationally last night, my friend had just got out of hospital and had some spare. But my dose was too low to do much other than mellow me out a bit).

 

[BilZ0r]

All drugs build up in your body if you take them often enough.

Taking the tramadol at 200-250mg doses twice a week should not completely nullify the effects of MDMA? is it possible I get about 75% of the mileage out of the bean if I wait about 72-96 hours to take the bean? and then after 1 week plus I should be all clear? Since I only took ultram 6 times.

Those all sound like reasonable geusses. Still, be careful mixing drugs.

 

[GoddessD]

MDXX mixed with opiates

Many of you guys in here are pretty knowledgable...so in PR they are debating a pill that a few people say is mixed with morphine...Can someone with some knowledge give me some kind of insight on how dangerous his would be. Also it looks like ecstacy data did a report on one of these, yet shows this pill being 2 MDMA 1 Caffeine and 1 MDA...if there was some other type of substance wouldnt it be shown? Personally, I find mixing these types of drugs would raise the "danger" level significantly...

 

[GhostWriter]

It is my opinion that the pill tested on PR is a different batch. It doesn't make sense. MDMA+MDA+caffeine = uppity pill.


..i personally also doubt the presence of an opiate. Tho something is def. dangerous about this pill. someone I knew in San Diego died after taking 2..

 

[spookz]

Yeah theyre floating around so cal and alot of people have enjoyed them but theyre kind of sketchy to me.

From what ive gathered the machine ecstasydata.org used to test pills cannot detect opiates. These are shady bombs I suspect they really are MDMA + MDA + Caffene + plus some sort of opiate..... they tested positive for mdma...so I dont doubt that....but when there is something dangerous in a pill (I heard about someone dying off these too) and the 'average' consumer gets it they dont know their limits and use it stupidly.....which can turn very bad.


This world deserves pure mdma and this is directly related to this fine chemical being an illegal drug. When is society gonna grow up??????

 

[swifty]

pills do not get cut with opiates, it would be too expensive to be orally active, and if someone where trying to sell opiates, they would just sell them as opiates to people who wanted to buy opiates, not put them in pills hoping no-one would notice.

 

[spookz]

^^Youre right they generally shouldnt/wouldnt contain opiates...but these for some reason semm like they do. Check them out on the South West forums on pillreports.

 

[GoddessD]

Swifty, I felt the same way you did....it seem that people who are taking the pills are getting some mdma affects along with morphine affects...as in laid back, sleepy, feeling itchy....I would think that if there were other substances in the pill then ecstacy data would show it as "unknown" substance if it was unable to detect?? But there is definatly something fishy about these beans.

 

[swifty]

This should clear any doubt:

Related Myths
Note – Sometimes people send "bogus" pills to analytical testers. Basically someone will add an adulterant to press up a single bogus pill with the intention of creating or furthering a myth (sort of like people who put razor blades or needles in Halloween candy).

1. Ecstasy contains heroin
Status: Basically a myth
There have only been one or two pills that tested positive for heroin. A search on ecstasydata.org would confirm this. If someone says they felt ‘smacky’, and blames this on heroin in the pill, they are mistaken. The effects were caused by another drug, possibly ketamine or MDE.

2. The colour/appearance of a pill is indicative of its contents.
Status: Untrue
The colour/appearance of the pill means absolutely nothing. A quick search on ecstasydata.org would turn up many pills of different appearances with the same contents; or with the same appearance, but different contents.

3. Ecstasy contains mescaline
Status: Untrue
No pills have ever been tested and shown to contain mescaline. A search on ecstasydata.org would confirm this.

Mescaline is incredibly hard to get hold of – there is absolutely no way that someone would waste it by selling it as Ecstasy. If someone had mescaline, they would sell it to people who wanted to buy mescaline. Furthermore, an active dose of mescaline would not fit in a pill.

4. Ecstasy contains LSD
Status: Untrue
A search on ecstasydata.org returns no hits for LSD. This suggests that, if LSD is ever found in pills, it is found very rarely. Hallucinations are possible on high doses of MDMA. However, major hallucinations are more likely to be due to the presence of some adulterant in the pill – MDA is a strong possibility.

5. Pills contain crushed glass
Status: Untrue
Source: various, including Time Out and Mix Mag (UK magazines).
No pills have ever been tested and shown to contain glass. A search on ecstasydata.org would confirm this. When the root source for this claim was tracked down, it turned out to be a dodgy and self proclaimed manufacturer who produced zero evidence to support his claim.

6. Ecstasy is a mixture of heroin and cocaine
Status: Untrue
True Ecstasy is MDMA. It’s a completely separate chemical; it has nothing to do with either heroin or cocaine either chemically or in its effects. Pills sold as Ecstasy may contain substances which aren’t MDMA. PMA, ketamine, DXM, caffeine, speed, MDA, and MDEA are all found in pills sold as Ecstasy. Heroin and cocaine are almost never found in pills sold as Ecstasy, and have never been found in the same pill. See ecstasydata.org for more.

7. Ecstasy contains rat poison
Status : Almost a myth
Source : Various, including Time Out and Mixmag.
One pill in Holland was tested and found to contain rat poison, although this was probably a result of contamination. Reports that large numbers of pills have been found with rat poison in them are a myth. The root source for this myth was the same as for the crushed glass myth. See this thread for more.
Last edited by Orlando on 30-05-2003 at 15:04

I hope this helps...

 

[GoddessD]

I know all of the myths, believe me....my question is...if a pill had an opiate substance in it and was sent to edata, wouldnt it show up on their contents as either the opiate or an unknown substance??

 

[BilZ0r]

^ It would almost certainly turn up as morphine. It is also slightly dangerous. I wouldn't worry much, but I wouldn't take opiates and MDMA at the same time, if I didn't have to.

 

[potato]

This should clear any doubt:

Related Myths
Note – Sometimes people send "bogus" pills to analytical testers. Basically someone will add an adulterant to press up a single bogus pill with the intention of creating or furthering a myth (sort of like people who put razor blades or needles in Halloween candy).

1. Ecstasy contains heroin
Status: Basically a myth
There have only been one or two pills that tested positive for heroin. A search on ecstasydata.org would confirm this. If someone says they felt ‘smacky’, and blames this on heroin in the pill, they are mistaken. The effects were caused by another drug, possibly ketamine or MDE.

Or even MDMA. There are so many people out there that describe pills which are high dose MDMA as 'smacky'. Example is the recent batch of orange butterflies. People are so used to Meth in thier pills that when they get a high dose of MDMA and it floors them (with what I would consider classic effects) they complain about not being able to dance and 'smack' in their pills.

 

[Sprinklervibes]

Or even MDMA. There are so many people out there that describe pills which are high dose MDMA as 'smacky'. Example is the recent batch of orange butterflies. People are so used to Meth in thier pills that when they get a high dose of MDMA and it floors them (with what I would consider classic effects) they complain about not being able to dance and 'smack' in their pills.

Saying "they're so used to meth" is probably overstated.. Low(er) doses of mdma can give much energy(though I always find mdma to give relatively controllable energy), mda has a little more twitchy body energy to it(some wrongly think they have speed when they actually have mda pills), then you have the (meth)amphetamines which almost don't allow you to sit still, then ephedrine/caffeine which are another kind of twitchyness..

 

[TheDrugStore]

I know exacly of the pills you speak of. There are acually 2-3 differen't batches of different kinds. 2 of which are white square "K's" with and without blue specs. The one with the blue specs was the one tested by the ecstasy data.

In my expirence with these things, i had the one without specs. I would put down money that these things has some sort of opiate in them because of the exact feeling it gave me. I felt like i took a high dose of tylonal 3. My skin was ichy as hell and i had to fight myself from falling asleep. They made me extreamly confertable and a little hungry.

Overall the pill was nothing like ecstasy in my opnion. I had never before felt an "E" high like that. I could be wrong though. Maybe these pills i got contained an extreamly high dose of MDMA giving me such a feeling.

A question i would like to have answered is if the meaning of the "K" on these pills means Ketamine....

 

[eric987235]

pills do not get cut with opiates, it would be too expensive to be orally active, and if someone where trying to sell opiates, they would just sell them as opiates to people who wanted to buy opiates, not put them in pills hoping no-one would notice.

10mg of hydrocodone would most certainly be orally active. But you're right, it wouldn't be worth the cost.

 

[Sprinklervibes]

^^ Cost isn't a real argument... The people that press pills could possibly get opiates very cheap, maybe cheaper than ecstasy.

 

[therollingstoner]

I wouldn't put it past some shady chemist to put some sort of opiate in pills. I hope more info comes in on these, as they could definately be dangerous.