Mechanism of MDMA conversion to MDA?

[Mr. White]

I've searched and i couldnt find anything:

So its known that a portion of MDMA will be converted to MDA when ingested, but does anyone know what the mechanism/enzyme is thats responsible?

I'm looking for a way to increase the portion of MDMA converted to MDA, probably by inducing the enzyme responsible.

Any takers?

 

[Advanc3d]

CYP3A4 metabolises it to MDA

why would u want to increase MDA from MDMA?
MDA is more neurotoxic than MDMA by a few folds

 

[Mr. White]

I've had MDA a couple of times and it was a blast, a different experience to mdma for me. I really liked the mild, not-overpowering visuals it gave me, especially combined with weed.
Seeing as MDA is rather hard to come by for me, this seemed a reasonable method to ingest some.

Neurotoxicity is not a major concern of mine, dont get me wrong, its a concern but i feel i mitigate these risks reasonably well.. I roll no more often than once every two months, no more than two pills, pre/post load heavily.

And lastky, thanks for the info! Do you know what percentage of MDMA is typically converted?

 

[<pyridinyl_30>]

(1) As far as I know what you are trying to do is impossible.
and
(2) Only a small percentage of MDMA is converted to MDA.

 

[Mr. White]

What do you mean impossible? Everyones body does this.
I'm not trying to convert ALL the MDMA to MDA, but to increase the proportion that does.

I know only a small percentage is converted, but is that on the order of, say, 1-2% or 10-15%?
I might try incucing CYP3A4 next time i roll and see what happens. Nobody can see anything dangerous with this (other than the increased toxicity of MDA) can they?

 

[Sturnam]

What do you mean impossible? Everyones body does this.
I'm not trying to convert ALL the MDMA to MDA, but to increase the proportion that does.

I know only a small percentage is converted, but is that on the order of, say, 1-2% or 10-15%?
I might try incucing CYP3A4 next time i roll and see what happens. Nobody can see anything dangerous with this (other than the increased toxicity of MDA) can they?

impossible in that even with 10% metabolism rate, you'd have to ingest 1g (1000mg) of MDMA to get a 100mg dose of MDA.
for it to be effective, without getting dangerous, you'd have to get 30-50% metabolism rate of MDMA to MDA.
the metabolism rate mentioned in this article says that in squirrel monkeys the ratio of MDA to MDMA was 3-5:100. basically, that gives you a 3-5% metabolic conversion rate that you have to amplify 10 times. good luck

article:
http:**jpet.aspetjournals.org/cgi/reprint/jpet.108.141366v1.pdf
(replace stars with // )

 

[Mr. White]

I'm not aiming to end up with a full dose of MDA.
The aim was instead of having say a 4:96 ratio of MDA:MDMA as above, but shift it to something like 15:85 or something like that.

Now that might be a barely threshold dose on its own, but with the with the mixture i'm willing to bet it will have an effect, however light

 

[UnfortunateSquid]

Very interesting article, Sturnam.

If it is to be believed, inducing CPY3A4 will only serve to faster remove the methylene bridge, forming more of the unpleasant methylated dopamine derivatives associated with the negative aftereffects of MDMA.

 

[rickolasnice]

CYP3A4 metabolises it to MDA

why would u want to increase MDA from MDMA?
MDA is more neurotoxic than MDMA by a few folds

MDA's more fun (imo)

 

[chemical messiah]

MDA's more fun (imo)

ditto