Mechanism and binding affinity of propylhexedrine

[Lightning-Nl]

Also, the aromatic ring is required for SERT and DAT affinity. You would probably end up with something that was NE specific, if active at all I would think.

Thanks a lot for the info. Although, Propylhexedrine actually does have affinity for DAT and SERT and, believe it or not, has higher affinity for the SERT than Amphetamine does. Granted, the affinity is only one margin higher and it lacks significant DAT affinity. Maybe this would give it higher affinity for the SERT? Or perhaps even 5HTr affinity? I don't know. Either way, it wouldn't be all that great of a drug - it lacks sufficed DAT activity.

 

[SeenSoFar]

Thanks a lot for the info. Although, Propylhexedrine actually does have affinity for DAT and SERT and, believe it or not, has higher affinity for the SERT than Amphetamine does. Granted, the affinity is only one margin higher and it lacks significant DAT affinity. Maybe this would give it higher affinity for the SERT? Or perhaps even 5HT affinity? I don't know. Either way, it wouldn't be all that great of a drug - it lacks sufficed DAT activity.

You are absolutely right! Sorry about that. I had a bit of a brain fart there! I was thinking of DMMA and the like, the non-CYCLIC analogues of better-known sympathomimetics, which do indeed lose all affinity for everything but NE. It's possible that your MDPHex might possibly have some of the activity you're hoping for. Who knows...

Yeah, duh, put that down to me being better at smoking speed than doing ochem (orchemwank or whatever this is we do here). Of course, when you 0 0r 1, there's no 2 option.

sekio, I've said it many times, but if you can't get chemdraw, ISIS is a decent and much freer second. I gave up on that doodler, why bother when this:
http://accelrys.com/resource-center/downloads/freeware/index.html
is free?

SSF, like I said, I was always told to find the longest alkane, so I was surprised not to see "prop" anywhere. I really appreciated your post- not being afraid tto tell me where I'd made stupid mistakes, and explaining the theory so I can learn for another time. Thanks, dude/tte. Sometimes people who know more than us come in, scoff, tell us we're stupid, and don't take the the time to explain where we've gone wrong. What I learn in ADD, I then use in other forums, so there's a trickle-down of knowledge, and a couple minutes of time spent explaining chem or something here can really help the community. Not everyone does it, not even staff sometimes, so thanks man, it really is appreciated that you take the time to help amateurs like us grasp these concepts.

No problem man, I'm glad I could help, and it's dude, not dudette . I've never understood what someone would hope to gain by mocking someone's mistakes instead of helping them work past them.

 

[ebola?]

Thanks a lot for the info. Although, Propylhexedrine actually does have affinity for DAT and SERT and, believe it or not, has higher affinity for the SERT than Amphetamine does. Granted, the affinity is only one margin higher and it lacks significant DAT affinity. Maybe this would give it higher affinity for the SERT? Or perhaps even 5HT affinity? I don't know. Either way, it wouldn't be all that great of a drug - it lacks sufficed DAT activity.

Where are you getting this? I've searched the liteteature thoroughly and found no binding affinity data, though SAR suggests activity similar to methamphetamine but with reduced potency and increased adrenergic action.

 

[SeenSoFar]

Where are you getting this? I've searched the liteteature thoroughly and found no binding affinity data, though SAR suggests activity similar to methamphetamine but with reduced potency and increased adrenergic action.

I'm not sure about SwampFox56, but I got my information from the DrugBank.ca entry on propylhexedrine, although the information wasn't really sourced, so I have no idea if it is just someone extrapolating from the SAR of methamphetamine, or if it's actually based on research. I had thought until recently that aromaticity was required for affinity to any monoamine receptor or transporter besides NE, so I don't know. I do notice an inconsistency on that site, it says in one place that propylhexedrine is an NE and DAT releaser, and then directly below that states that it is also a 5-HT releaser, then further down it says it's targets are the VMAT and TAAR1, so who knows?

 

[Lightning-Nl]

I'm not sure about SwampFox56, but I got my information from the DrugBank.ca entry on propylhexedrine, although the information wasn't really sourced, so I have no idea if it is just someone extrapolating from the SAR of methamphetamine, or if it's actually based on research. I had thought until recently that aromaticity was required for affinity to any monoamine receptor or transporter besides NE, so I don't know. I do notice an inconsistency on that site, it says in one place that propylhexedrine is an NE and DAT releaser, and then directly below that states that it is also a 5-HT releaser, then further down it says it's targets are the VMAT and TAAR1, so who knows?

My understanding is that it's functional efficiencies are nearly identical to that of Methamphetamine, but it's bind affinities are much, much lower. Except to the NET. Methamphetamine still has much more affinity for NET, but propylhexedrine's action is primarily Noradrenergic.

I believe I also remember reading that Propylhexedrine also has some appreciable affinity for Alpha-Adrenergic receptors.

 

[ebola?]

To repeat (since you have apparently decided to do so), where are you getting this information?

ebola

 

[Lightning-Nl]

To repeat (since you have apparently decided to do so), where are you getting this information?

ebola

Jesus! I don't remember! I know I read it when looking through all the sources listed at the bottom of the Wikipedia page, but otherwise I don't know the exact study! I guess I'll look for it.

 

[atara]

thread split because y'all can't stay on topic

Jesus! I don't remember! I know I read it when looking through all the sources listed at the bottom of the Wikipedia page, but otherwise I don't know the exact study! I guess I'll look for it.

Dude, you can't be so lazy. Don't expect other people to find your studies for you. If someone asks for a source for something you've said, it's polite to put in the time to find it for them. It's not their job to compensate if you forget.

pats head

Propylhexedrine also has some appreciable affinity for Alpha-Adrenergic receptors.

http://reference.medscape.com/drug/benzedrex-propylhexedrine-343411#10
http://jat.oxfordjournals.org/content/35/1/54.full.pdf

You're welcome, broski.

 

[Lightning-Nl]

thread split because y'all can't stay on topic



Dude, you can't be so lazy. Don't expect other people to find your studies for you. If someone asks for a source for something you've said, it's polite to put in the time to find it for them. It's not their job to compensate if you forget.

pats head



http://reference.medscape.com/drug/benzedrex-propylhexedrine-343411#10
http://jat.oxfordjournals.org/content/35/1/54.full.pdf

You're welcome, broski.

Thanks for that, you saved me time.

Just curious. Did you get that from the Wikipage? Or did you just google it?

 

[atara]

Thanks for that, you saved me time.

Just curious. Did you get that from the Wikipage? Or did you just google it?

Medscape was on the wiki, the article was from Google Scholar.