Me + Tryptamines = Bad combo. Why?

[Lost Ego]

I've tried many tryptamines and none of them react with my brain in a positive manner. For instance i tried some salvia yesterday. I took 4 hits of some gewd stuff and the drug it was hard to open my eyes, the water bottle bong in front of me was dancing in front of me and it was like a commercial on tv but it kept repeating some murmurred message which quickly made the trip unpleasant. It wasn't long before i was becoming paranoid and wanted my 15 mins to be up, i didn't like the feel of the drug, nor the thought processes that it triggered. It was the same with acid, not much fun. The only one that was near bareable was dmt and that was over b4 i knew it. Is it that i can't let go of control? I dont think that's it, nor is it the set or setting. I think it has to do with the chemistry in my brain, but what exactly? In what way do tryptamines interact with the brain in a different way than phenethylamines and disssociatives? Why the paranoia and discomfort while on all tryptamines? (for me)

I just want to be able to try and enjoy acid, mescaline and peyote... The effects reported on erowid are much closer to what im looking for to reach a new state of mind. All tryptamines have done is made me feel a tad crazy and adopt alot of skepticism.

 

[whataboutheforests]

salvia isn't a tryptamine. Neither is LSD.

What else have you tried besides DMT? I could see how you would find that experience uncomfortable, have you tried mushrooms? Although the trip can be more paranoid and uncomfortable than LSD or some 2C-X's, it is generally way more gentle than blasting off into the DMT void.

 

[Lost Ego]

LSD and salvia are so tryptamines! They have to be! I can't believe my ears. I always thought... nvm. And dmt was hardly uncomfortable, i was having a bad trip the second time i did it but i was able to keep myself peaceful. On salvia and lsd i was experiencing auditory hallucinations, mass anxiousness, etc. Perhaps i should try some shrooms then, i was about ready to close myself off to "tryptamines" and i apparently didnt know wtf the class consisted of

 

[NeighborhoodThreat]

Salvia isn't a tryptamine. It's a plant. Salvinorin A, the active psychotropic drug in salvia, isn't a tryptamine either...

A simple Wikipedia or Google search would have told you this. Not all tryptamines are the same. It's a very vast class of drugs with very different properties. Just because you tried one and didn't enjoy it doesn't mean they're a "bad combo" for you.

 

[Lost Ego]

^ haha seratonin and tryptophan are tryptamines lol, who would have thought it. i know a bit about these chemicals. And i suppose it's not as broad of a drug class as i thought

 

[2c-goinsane]

LSD is a ergoline iv read its like a cross between a PEA and tryptamine. salvia is considered a dissociative if im not mistaken but it doesnt activate like other dissociatives.

Any of the classes of psychedelics can be uncomfortable/paranoia drivin, really comes down to your mind set/setting and dose ime.

 

[sekio]

Some people just don't like hoe the tryptamines 'interact' with their receptors. They do have some differences from e.g. pehenthylamines and ergoloids.
In general set and setting plays a large part as stated above.

You do seem confused as to what tryptamines are - they are the chemical class of drugs that has a tryptamine backbone. Alexander Shulgin wrote a book called TiHKAL - Tryptamines I Have Known And Loved - that details a lot more about them.
Common tryptamine drugs include:
DMT, DET, DPT, DiPT et cetera
aMT, aET, 5-MeO-aMT
Psilocin, psilocybin, (mushrooms) 4-AcO-DMT
5-MeO-MiPT/DiPT/DMT

LSD is indeed an ergoline. It technically does share the 'backbone ' of phenethylamines and tryptamines, but the molecule is granted its potency because of its special shape. The "extra scaffolding" grants it the special property that most of the molecule is entirely flat (planar).

Peyote/mescaliine is not a tryptamine -it is a phenethylamine. See PiHKAL for more on those.

Salvia is not a tryptamine, and lots of people have trouble with it. It's really in a class of its own.

 

[daytryptr]

I can relate to the OP, while i don't have enough issues with trypts in general to turn me off from them, i'd take mescaline or LSD over 4 subs, dmt, ayahuasca, mushrooms, etc 8 days a week.

LSD at the right dosage imho is middle ground between the tryptamine arena and phenethylamine arena as far as psychs go. Best of both worlds. Mescaline is ime almost impossible to have a bad trip on, and one of my favorite psychs. A few 2c-x's/25x's prob could give it a run for its money, but g-pa mescalito could take those motherfuckers anyday.

Salvia(which isn't a trypt anyway)/Smoalked tryptamines, imho, are one of the roughest rides there is, even though the experiences are very different. If i had to introduce a first timer to trypts is would be a low dose of mushrooms, or maybe 10mg of 4-aco-dmt, 4-ho-met, or 4-ho-mipt orally. Smoking dmt is not for everyone, or most people really imho. Its the single most jarring experience I've had with psychs.

 

[777xog]

As a general rule, no one "enjoys" salvia.
and DMT is really powerful stuff.

I think anytime a psychedelic is smoked, it has a higher tendency to cause discomfort and confusion because how fast it comes on.

 

[Anon0631]

^ haha seratonin and tryptophan are tryptamines lol, who would have thought it. i know a bit about these chemicals. And i suppose it's not as broad of a drug class as i thought

Tryptophan isnt a Tryptamine. It is the amino acid that tryptamine is derived from.

 

[blazR]

Tryptophan isnt a Tryptamine. It is the amino acid that tryptamine is derived from.

Well yeah, Tryptophan IS a tryptamine

 

[OPANAMONIUM]

All of the substances you listed arent tryptamines. Lsd is an ergoloid, I cant recall the classification of salvia atm bit I know its not a tryptamine. And mescaline, the active substance in peyote, is a phenethylamine.

 

[Lost Ego]

Lol i feel like an idiot now but it's cool i suppose i learn something new every day... :D

As a general rule, no one "enjoys" salvia.

Yeah it was a bit unsettling, i'm thinking that i'll try a lower dose this weekend (as i have a ton left) and see if i cant control it with better music and a more positive state of mind.

Some people just don't like hoe the tryptamines 'interact' with their receptors.

Could you guys teach me more about how tryptamines, phenethylamines, ergolines and psychedelics individually interact with the post-synaptic neurons?? And then cross reference them? I took biopsychology and i get the basics down (so i should be easy to teach) but what im lacking is how organic chemistry plays into it all as i've never taken chem, nor pharmocology. If you aren't up for teaching me in depth how it all works, can you point me in the direction of a class that would - short of psychopharmocology because it'd take me 6 years to reach that point lol.

I really wanna figure out what's wrong with my brain chemistry and see if i can't correct it somehow so i can enjoy certain drugs.