• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

MDPV - So how dangerous is it?

O

offwhite

Greenlighter
Joined
Aug 21, 2009
Messages
4
Hi board, I'm new here. I've been following the MDPV discussions with some interest, and I've tried the substance myself at a number of occations.

One thing that doesn't seem very clear to me though is whether it is neurotoxic or not.

I know this:

Riemann Zeta said:
Monoamine oxidase B oxidizes extrasynaptic dopamine to dihydrophenylacetic acid and hydrogen peroxide, an oxidative diradical product. Inhibiting MAOB prevents oxidative stress to dopaminergic neurons in the striatum.
Click to expand...

But it shouldn't really apply to dopamine reuptake inhibitors since the dopamine isn't metabolized, only hindered from reuptake.

But still, some people claim MDPV to be neurotoxic in some way. Anyone who could explain this to me?

I am taking MDPV semi-regularly to combat ADD-Pi in awaiting a real investigation for whether I'm gonna get prescript stimulants or not.
 
^ Well MDPV was originally chosen as it is the least toxic of all the pyrovalerone derivatives. I doubt any toxicity is going to occur in the same manner as MDMA as MdPv has bugger all effect on serotonogic systems

can you give a link to someone claiming it's neurotoxic as I'm curious to see the rationale behind their arguement?
 
I doubt that its especially toxic...

Maybe a decrease in striatal DAT density would occur after regular use....
 
I don't know if there's any research to possible cardiotoxicity of MDPV, but I have a gut feeling it just might have some issues. The stuff does crazy things to your heart rate, at least when intravenously used. Then again most stimulants do.

Although, around here MDPV has already caused several deaths due to idiots selling it as a speed/meth substitute (or even in some cases, simply selling it as speed) and unfortunate and/or ignorant people not knowing the correct dosage and overdosing accordingly...
 
I think the real danger is with getting strung out and acting like an idiot.

Nothing really dangerous about changes in blood pressure or pulse that I noticed.
 
I don't like the way it makes me feel the day after... like my brain has had a jagged square or saw synth lead put through it... when it likes nice smooth, analogue sine waves.

Having said, I have seen people do some deeper inner work with it... (myself included)... but I doubt I will ever do it again.

I think it is dangerous in that it is VERY addictive... moreso than anything else I know of. People who have managed to run the gauntlet of every other drug and not get addicted are having real difficulty with this stuff... and for very little benefit it seems to me.

To my mind, it seems like a "good" drug to get some cleaning or work... I need to clean up my office now, but I'm certainly not reaching for it! Not worth it!


Julian.
 
negrogesic said:
Does MDPV have significant affinity for the SERT?
Click to expand...

There's been a lot of hearsay about MDPV being a DAT specific substrate, but I don't really think it is (yet to see any data). That said, there has been a lot of talk about colour enhancement on MDPV, which would point to it perhaps being a mild 5HT2A agonist, but I haven't seen anything like that while taking the drug. Just a very tweaky stimulant with mild to moderate euphoria. The abuse potential is strangely so high that you might think it's a tri-aminergic reuptake inhibitor like cocaine, although the duration of action could be the problem as well.

Contrary to above user, I never had any lasting after-effects or depression. Mood was fine when I came down.
 
nuke said:
I think the real danger is with getting strung out and acting like an idiot.
Click to expand...
yes, it is....that side cost me my girlfriend and my best friend:[
folias said:
I think it is dangerous in that it is VERY addictive... moreso than anything else I know of. People who have managed to run the gauntlet of every other drug and not get addicted are having real difficulty with this stuff...
Click to expand...

fuck is it addictive. I lost my meth habit for peevee
 
In Finland. No I don't have links, and I can't really vouch for the accuracy of the information. There could have been other substances involved in the incidents as well.

Actually now that I looked into it, it could very well be possible the whole thing is just police propaganda... I can find lots of references to "the dangerous new sex drug" (which is what the media likes to call it) causing overdoses but can't actually find any incidents where MDPV overdose would have been lethal...
 
In my opinion this stuff is far more dangerous then amphetamine, it got me damn worried it was getting a heart attack once, this stuff also makes me extremely paranoid.
 
It's less toxic than the version that made it as a medicine (pyrovalerone) and that's pretty non-toxic in comparison to most other stimulants, so the more dangerous than amphetaine I can only see applying in the sense of it's capacity for psychological addiction. In terms of theraputic ratio, I think it outdoes amphetamine, or is at least not worse.
 
fastandbulbous said:
It's less toxic than the version that made it as a medicine (pyrovalerone) and that's pretty non-toxic in comparison to most other stimulants, so the more dangerous than amphetaine I can only see applying in the sense of it's capacity for psychological addiction. In terms of theraputic ratio, I think it outdoes amphetamine, or is at least not worse.
Click to expand...

It sounds like you're confusing its neurotoxic potential with its capacity to induce untoward peripheral effects through stimulation of adrenoreceptors?

A drug can have a higher lethality index than amphetamine while being less neurotoxic.
 
I've had arrhythmias from high dose of MDPV, which worried me a bit as I never got that from meth or coke...I reckon it produces active metabolites which are perhaps not so friendly as the parent compound.
 
ah your talking about PPP? sounds like a really nice chemical, i keep wondering about 3,4-Chloro-PPP *without* the beta keto group...

have the metabolites of MDPV been studied? i would assume it is metabolized into
3,4-HO-PV ---> 3-MeO-4-HO-PV as is the case for its close relative MDPPP
 
You must log in or register to reply here.
Top