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MDPV Dosing...

M

MDPVagrant

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USA... *sigh*... sux.
I have a question regarding MDPV dosing - if you've tried it on your lab subjects, how do you determine the borderline between optimal DRI and spillover into ugly norepinephrine effects (or so it appears)? The stuff seems to have a VERY narrow "therapeutic" index, and I'm having difficulty lately figuring out how to determine it for a given animal. Just wondering how you do it.

P.S. substances that do not 'scale' at higher doses sure are annoying... 8) I tend to eventually abandon their use in my experiments, due to recurrent problems. IMO, kratom / mitragynine is another example -- opiate-like effects to a certain dosage, then suddenly horrendous nausea and gastric shutdown. Not sure if this is related directly to the alkaloids tho.
 
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I think F&B said the 3,4 dichloro analog was 'top of the heap' in binding essays, why not simply switch your research to that compound?
 
MDPV proper dosing is tricky and seems to vary w/every batch. so far, the only rule that seems to work - if wanting to redose NOW, wait 20 minutes...
 
haribo1 said:
I think F&B said the 3,4 dichloro analog was 'top of the heap' in binding essays, why not simply switch your research to that compound?
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Not asking where to get it, but did he say it was readily available? I don't have a chem lab here, after all (and custom synths can be pricey).
nanobrain said:
MDPV proper dosing is tricky and seems to vary w/every batch. so far, the only rule that seems to work - if wanting to redose NOW, wait 20 minutes...
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I get the gist, but are you sure it works? 8( Anyway, thanks mucho.

P.S. I've discovered that chronic dosing seems to build up tolerance to the jittery/agitated type effects, but that's hardly a real-world solution. If the only way MDPV can be used at all is via binging, the stuff has little future.
 
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Fwiw, I'm experimenting with MDPV as possibly the first true aphrodisiac that doesn't keep you awake for 17 days & nights raving about the cops under the bed with plutonium rayguns =D (leave it to homosexual men to discover and exploit this aspect of meth... I'm paying a compliment, I'm not gay but admire the open attitude and connoisseur-like approach toward sex).

Trouble is, dosing really seems to be a black art with the stuff, particularly when trying to maximize sexual response without causing 2 hours of "I just drank 79 cups of coffee" afterwards. It's bearable, but easily ruins the whole thing.

So far the best MOA seems to be intranasal MDPV dissolved in dh2o, which is absorbed incredibly rapidly (seconds) and allows very fine control of dosing. Even this however is very difficult to get right. Still better than having mutated aliens speak to you from the closet tho :p -- I've heard tell of MDPV psychosis, but it appears much less common. Anecdotal evidence suggest various self-limitations cropping up ~96 hours at the outside, provided dosages aren't extreme during that period.

Next up perhaps -- an aphrodisiac cocktail: Xanax 0.25mg, a fast-acting PDE5 inhibitor and a generous sprinkle of MDPV (unless crossing it with a vasodilator causes unsafe levels of hypotension... some preliminary experiments I did suggest it's possible, at least with stuff like calcium channel blockers & β-blockers... another potential issue could be tachycardia).

P.S. all my posts on this thread are meant to be unscientific & semi tongue-in-cheek BTW... I *am* very interested in MDPV tho, as my username suggest.
 
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I use oral mucosa absorption and bump up doses about 1.5mg at a time 20minutes apart. Just take the powder and allow to dissolve under the tongue or between lip and gums. Kicks in really fast and does not have much of a taste. This allows appropriate titration and is easy with powder.
As to getting the dose right, this has not been a problem for me so far.
 
Part of optimal dosing would be giving stimulants a rest at some point.
 
MDPVagrant said:
^^ Good idea - I'm getting so damn sick of MDPV at this point. 1/2 a d@mn mg too much and it's 75-cups-of-coffee time. Uggh, pfft.
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vallies are the antidote.
 
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That being said, Ive taken the cust every day for 1.5 years.
I dont like my life at the moment due to what I beleive to mdpv. so watch out. mdpv paranoia is some boy-oh.
 
The tolerance to MDPV rises very fast IME. On the first day you might shoot 25mg at a time, a day or two from there it's 50mg at a time... day or two more and it might double again, but I've never taken it so far and don't intend to. The things this stuff does to your heart rate on higher dosages are something nasty.
 
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