MDPV comedowns

[Genetic Freak]

I've heard the comedown on high doses of MDPV can be pretty harsh, I was wondering if dietary supplementations such as L-tyrosine, could be taken to prevent this..?

I have read: MDPV functions as a dopamine-norepinephrine reuptake inhibitor (NDRI), IE: it inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an increase in neurotransmission.

I'm assuming a dopamine depletion will occur at some point and that would be the cause of the comedown effect.... Normally L-tyrosine is converted to L-dopa by tyrosine hydroxylase, L-dopa is rapidly converted to dopamine by L-amino acid decarboxylase.... I had read that when taking MDMA, L-tyrosine and L-phenylalanine wasn't effective at quickly increasing Dopamine levels because tyrosine hydoxylase, a key enzyme in the metabolic pathway which converts the amino acids into neurotransmitters, is usually saturated..... Is this the same with MDPV...???

Would taking L-dopa by-pass tyrosine hydroxylase saturation and increase dopamine levels sufficiently to decrease depression associated post-MDPV.. If this is indeed the cause..?

Your comments are welcome..

Thanks....

 

[Jabberwocky]

I highly doubt anything short of a powerful sleep inducing sedative would help the MDPV come down when the subject has been using moderate to high doses of the drug... this just from my personal experiences with that fucking drug

 

[Albion]

I very much doubt it. MDPV comedowns are horrendous, and I don't think any amount of supplements is going to make a noticeable difference. Food and sleep would likely do more for you. I'd like to hear the opinion of someone with advanced knowledge in this department though...May even be worth sending this over to ADD.

 

[tricomb]

I've had old friends bang on my door desperate for a shot of thorazine or haloperidol because of MDPV. I'll never do that drug.

 

[Jabberwocky]

Yea jspete I'd also like to see what those fools over at add think

 

[Albion]

They ain't fools, they're wizards.

Moving to ADD for curiosity's sake.

 

[sekio]

The best thing for stimulant comedowns are:
1. time.
2. benzodiazepines, barbiturates, opioids, or other high power sedatives
3. not doing any more drugs for a while

If you eat a reasonable amount & variety of protien in your diet supplementation will only hurt your wallet.

 

[FlippingTop]

GBL (preferable GHB) is a life saver for a MDPV comedown..., and a short acting strong benzo, Xanax or etizolams.

I was using zopicones to get to sleep when using MDPV before and it worked a treat actually... I was quite suprised

 

[oar9fi]

When I had a gm of MDPV (got it free) I couldn't wait until it was all gone! Yes, it was useful at times but I found myself redosing AGAINST MY WILL. As in mind saying "Don't do this" while either prepping a line or mixing with baking soda on foil. The things that worked to keep me from it were olanzapine & one time I took apart a radio, put it inside & screwed it back together to make it a PITA to get at. The best method though was this:
I dissolved 500mg in 50ml of DH2O. that way it wasn't as immediately available (I wasn't plugging or shooting)
so I'd have to wait for it to evaporate. Oh, and it started off white but after evaporation it was tan (but not better.) Really the only crash I would get was "More! More! More!" & stupid excuses in my head as to why I needed more. MDPV is the devils painus, and I have felt that painus inside me. Word.

 

[titstypedthis]

Pre and post dosing phenylalanine with vitamins might both boost the length of positive effects and reduce the end binge retardation.

I wouldn't count on it tho

 

[kakti]

A benzo, possibly accompanied by some alcohol always worked for my friends. But then again they only dosed like 2-3 times per session, maybe 4 if they were going all night.

From what I recall, my friends said from insuffulation to sleep was about 4 hours - about an hour of eurphoria and 3 hours of plain-jane stimulant. For those that have done like 10 redoses, does the stimulant only effects stretch out or are they still about 3-4 hours after the last dose?

 

[nuke]

I've never really had an MDPV comedown, it was always smooth for me. But I imagine some opiates or sedatives (as with any other strong stimulant) would work. Not really ADD.