yes its possible, but dont expect a flash from one hit. you have to saturate the PG pretty well, that you can feel the stimulation after 5 minutes of vaping. i am also pretty sure you'll ruin your atomizer/coil with residue buildup. also 100mg in 2ml PG do not quite dissolve completely.
i dont have a pro e-cig, so i dont know how the good e-cigs do. just a plain evod2 with a bdc tank and 1.8 ohms.
dosage wise i see no problem for noids and some 2c's, also moxy or 5-meo-dalt/dmt should work, i wonder if MXE would work? but i doubt it.