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mdpea anyone?

T

toxide

Bluelighter
Joined
Mar 21, 2006
Messages
241
I've seen 3,4-methylenedioxyphenethylamine available for cheap by some chem suppliers. Shulgin said that there's no activity due to it's susceptability to mao,
judging from the fact that mda,bdb,mbdb,m1... are all quite positive, would it fair to assume that taking MDPEA with selegiline could be an interesting experience?
Can anyone with thier expertise in this area comment on whether this would be a worth while endevor, would it be like E at all, or would it be like a very mild moodlifting trip, when combined with an maobi what dosage would it take(just looking 4 opinions here)...
 
Would the Methylenedioxy part be more susceptable to opening as even the alpha-methyl might clog up enzymes that perform this function normally?

Yet taking selegiline wouldn't be a strong enough effect to prevent the above happening even if the PEA part remained^

If the methylene ring part did open quickly (even with maoi suppression) would you get a tyramine type effect as well.

All the above is a guess with no scientific basis btw someone probably know more real info. Am interested in the idea though. Could be quite an interesting effect.
 
I'm very interested in this, considering the surprisingly powerful effects of PEA itself in high enough doses or combined with selegiline, and the lack of toxicity in non-amphetamine, substituted PEAs. And I don't just mean 2C-x and the like, even para-chloroPEA which releases serotonin does not appear to be neurotoxic.

Needless to say, one would have to be very careful with this, considering the risk of serotonin syndrome.
 
I had read somewhere that the methyl group on the alpha position of the phenethylamine structure slows down the breakdown of the molecule structure from monoamine oxidase. Of course MDA, M1 and MDMA have this methyl group (MBDB has 2 carbons with a methyl group at this position). MDPEA doesn't, so its reasonable to believe a similar thing may happen here. I don't know whether the Methylenedioxy- makes a difference to the rate the molecule is broken down. I imagine concomitant use of an MAOI may be effective in slowing this breakdown.
 
I've thought about this many times. If I could reliably source a small quantity, then I'd definately give it a whirl with selegiline purely to satisfy my curiosity. The short duration of action would make it next to useless for recreational purposes... although the rush from PEA with selegiline was lovely for a good 20 minutes.

The fact that this substance is listed in PHiKAL leads me to believe it would be illegal in the UK, since they decided to just slap a BANNED sticker right across the entire book.
 
If you consider dopamine: 'cardiac dose' i.e used in heart failure and shock 2–5 micrograms/kg/minute (I make that roughly 21mg/hour) = positive ionotropic + chronotropic effects, increased cardiac output, vasoconstriction etc etc. [I am merely making the point that not too diferent compounds can have extremely potent peripheral vascular/cardiac effects]

MDPEA doesn't have TWO obvious polar hydroxyl groups however:
  • it's metabolites might (as mentioned above the alpha-methyl in MDA/MDMA might actually also help block enzymes/metabolism of the methylenedioxy part of the molecule through steric hinderince etc)
  • Even if not, it's got Oxygens in the corresponding places to dopamine and your involving a MAOI.

It might do something, personally wouldn't be surprised if the result was messy peripheral effects with not much/little CNS effect (if someone told me not much would get past BBB - I certainly would cry out in shock) TBH isn't there a report on this somewhere? If not, wouldn't be suprised if someone somewhere has tried it (if not with selegiline another maoi) - or put another way - fairly sure if it had done something interesting it would be known.
 
I think PEA itself should be metabolized into dopamine to some extent, and people have dosed grams of that and experienced no worrying cardiovascular effects AFAIK.

Edit: I'm speculating this based on the fact that amphetamine is metabolized into alpha-methyldopamine, but I can't find any evidence that this does actually happen. As always, be careful.
 
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The short duration of action would make it next to useless for recreational purposes... although the rush from PEA with selegiline was lovely for a good 20 minutes.
Click to expand...

Hmmm...IME, selegiline + PEA has a duration of more like an hour.

ebola
 
ebola? said:
Given my experiences carefully combining selegiline and PEA, I'd enjoy giving this one a very careful whirl.

ebola
Click to expand...

Is Deprenyl + PEA combo that good? Also, it seems like so many people here have had the experience with the two. Is Deprenyl that easy to get your hands on? Also, do you run any risks when taking the two, if done properly?
 
It was pretty good, until I accrued significant tolerance to the combination (oddly, I seemed to accrue tolerance to the synergistic effects of deprenyl and stimulants, not just to stimulants). Initially, the combo was like a 'more intoxicating' amphetamine with a duration of an hour. Deprenyl was rather easy for me to obtain from 2008-10 (it is not scheduled).

You run some significant risks, so you have to be really fucking careful. Multiple bluelighters have overdosed on this combination, to the point of physiological danger, as confirmed by measurements of pulse and blood pressure. I have written an FAQ on this, though, available on the bluelight wiki: Warning: I wrote this FAQ while on deprenyl and stimulants, so it's kinda verbose :P

ebola
 
Taking MDPEA complexed with HPBCD (or any CycloDextrin, possibly?) might be an interesting experiment! I really don't know anything about the pharmacology of HPBCD's except that they increase the water solubility of the chemical that's complexed with them, but I've been told that HPBCD has so far had an uncanny ability "release" the "full potential" of a lot of drugs (like making them more potent, for one) that have been tried by others that I'm aware of. Like 25I, 25C, AM-xxxx and so forth.

Also it might produce a really awesome experience if you could find a chemist to make some of it into MDPEA-NBOMe for you or if anyone who happens to have some MDPEA could figure out reductive amination and a source for 2-methoxybenzaldehyde. ...And you were to subsequently consume the MDPEA-NBOMe, of course. ;)
 
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Yaaa Ebola thanks for that link, fascinating, (and funny)and I'll ditto what Matt said. It must have been interesting for me to make my first post here in months just to confirm....
 
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