MDMA Replacement for People on SSRIs

[frenchi]

It's well known that SSRIs make it almost impossible to roll on MDMA, even after having stopped taking it weeks before. I'm wondering if anybody has suggestions on how a person on SSRIs could get a high similar to rolling.
I'm hoping there's either another drug that mimics the happy, euphoric effects but does not mess with the same receptors as SSRIs OR if there is something that can be taken with or before MDMA to somehow make it work despite the SSRI.

Any info is appreciated

 

[peanut 801]

A friend of mine has experimented with a female friend on SSRI'S with MDMA and MDA. she had never rolled before so he first dosed her with 100 mgs MDMA, NO effect at all! A few hours later he tried 100 mgs MDA AND she fuckin rolled tits!!

 

[sidestyle]

First of all, it is extremely unsafe to take any serotonergic drugs while on an SSRI or shortly after discontinuing an SSRI.

Secondly, the euphoric, feel-good lovey dovey-ness that accompanies an MDMA and/or an MDA experience is caused primarily by serotonin. I have had some similar euphoria caused by phenibut at concerts, but that's about as close as you'll get. My suggestion? Get off the SSRI's if you can, and if not, please don't take MDMA, as you are at very high risk for serotonin syndrome.

 

[Black]

First of all, it is extremely unsafe to take any serotonergic drugs while on an SSRI or shortly after discontinuing an SSRI.

Secondly, the euphoric, feel-good lovey dovey-ness that accompanies an MDMA and/or an MDA experience is caused primarily by serotonin. I have had some similar euphoria caused by phenibut at concerts, but that's about as close as you'll get. My suggestion? Get off the SSRI's if you can, and if not, please don't take MDMA, as you are at very high risk for serotonin syndrome.

what makes you think that? serotonin release by mdma is dependent on a functioning sert, which is why most people get barely any effects when they take mdma in ssris.

 

[BlueBull]

First of all, it is extremely unsafe to take any serotonergic drugs while on an SSRI or shortly after discontinuing an SSRI.

...

Get off the SSRI's if you can, and if not, please don't take MDMA, as you are at very high risk for serotonin syndrome.

That's absolutely wrong. If you've taken an SSRI combined with MDMA you are actually less at risk for serotonin syndrome than if you would have taken MDMA on its own. This is because the SSRI prevents MDMA from releasing serotonin, which actually causes lower serotonin levels than on MDMA alone. You are thinking of MAOI's, which almost always end in serotonin toxicity when combined with MDMA

A quote from a study

Substances that inhibit serotonin re-uptake are not likely to increase serotonin to life-threatening levels if used with ecstasy [23,26,31]. These substances include SSRI antidepressants (e.g. citalopram, fluoxetine, aroxetine), the SNRI venlafaxine, tricyclic antidepressants (e.g. clomipramine, imipramine), opioid analgesics (e.g. tramadol, dextromethorphan) and antihistamines (e.g. chlor pheniramine, brompheniramine). These drugs differ rom other serotonergic drugs in that they compete with MDMA at the serotonin receptor site and, therefore, diminish the effects of MDMA [23,31].