BlueBull
Moderator: MDMA
Hey Dan, Sorry in advance for the long post.
Yeah, that seems like a perfectly 'normal' severe comedown following MDMA abuse. All the symptoms you describe point in that direction. I would even go so far as to say that after such use your body seems to be handling it quite well. I used to abuse the shit out of MDMA, partly because of uninformed use and partly because of carelessness. And then I had my worst comedown yet (after using 4 days in a row, stupidest thing I've ever done with drugs) which made me change the way I used MDMA. The depression was absolutely crippling and it was constant, not periodical like in your case. I was suicidal every waking minute. I had massive anxiety attacks triggered by ingesting anything psychoactive, whether it was caffeine or THC. And on top of that I had brain zaps, heart rhythm irregularities, tremors, headaches,... The physical symptoms took about a week or two to completely clear up but the depression and anxiety took a while longer, the worst was over by the end of week 3 but I had lingering depression and anxiety for about 1.5 months. And just like you I only experienced very short comedowns before that if I had a comedown at all, 90% of the time I have an afterglow
It's your body finally telling you "enough is enough", it will recover in time and when taken care of. Look at it this way: with such abuse you are actually pretty lucky your symptoms aren't worse and if people that have it worse than you recover in time, you will too.
To ease your mind a bit about the possibility of having caused permanent damage a quote from a study:
Yeah, that seems like a perfectly 'normal' severe comedown following MDMA abuse. All the symptoms you describe point in that direction. I would even go so far as to say that after such use your body seems to be handling it quite well. I used to abuse the shit out of MDMA, partly because of uninformed use and partly because of carelessness. And then I had my worst comedown yet (after using 4 days in a row, stupidest thing I've ever done with drugs) which made me change the way I used MDMA. The depression was absolutely crippling and it was constant, not periodical like in your case. I was suicidal every waking minute. I had massive anxiety attacks triggered by ingesting anything psychoactive, whether it was caffeine or THC. And on top of that I had brain zaps, heart rhythm irregularities, tremors, headaches,... The physical symptoms took about a week or two to completely clear up but the depression and anxiety took a while longer, the worst was over by the end of week 3 but I had lingering depression and anxiety for about 1.5 months. And just like you I only experienced very short comedowns before that if I had a comedown at all, 90% of the time I have an afterglow
It's your body finally telling you "enough is enough", it will recover in time and when taken care of. Look at it this way: with such abuse you are actually pretty lucky your symptoms aren't worse and if people that have it worse than you recover in time, you will too.
To ease your mind a bit about the possibility of having caused permanent damage a quote from a study:
What this essentially says is that even in high, repeated and injected doses MDMA does not seem to produce signs of neurotoxic damage. 10-20mg/kg is about 700mg-1400mg for a human weighing 70kg, this was repeated multiple times on consecutive days and it was IV'd, which has a much higher bioavailability than when taken orally. MDMA can cause real neurotoxic damage, but only in insanely high and repeated doses (read: potentially lethal doses. >25mg/kg is >1750mg for a human weighing 70kg). So while your use is certainly unhealthy and could have caused some temporary physical and psychological symptoms, you have not caused permanent noticeable damage, it takes a lot more to do that according to this study. You are experiencing a normal, be it severe, comedown. Ride it out and understand that it will probably happen again if you continue using MDMA like that. Take care of yourself and I hope you are back to normal soon, if you have any more questions don't hesitate to ask. If you fancy a chat or for any other reason really you can always PM me. Keep us updated!With regard to MDMA-induced neurotoxicity, it seems that 5-HT deficits are not always synonymous with axonal death because doses of MDMA which cause marked depletions of brain tissue 5-HT in rats (e.g., 10–20 mg/kg) are not associated with silver-positive staining, reactive gliosis, or loss of SERT protein. Like many other psychotropic drugs, MDMA is capable of producing bona fide neurotoxicity at sufficient doses (e.g., >25 mg/kg), and damage is not confined to 5-HT neurons. Many aspects of 5-HT function appear to be normal in MDMA-pretreated rats despite significant loss of brain 5-HT, perhaps illustrating the profound adaptive capability of the CNS.
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