Its common for people to have a rough first couple of weeks on an SSRI - as time runs on some of the "bad" serotonin receptors might be desensitized faster than the "good" serotonin receptors, but the "bad" serotonin receptors can certainly get their fair share of stimulation for a while, but the "good" serotonin receptors are supposed to outpace the "bad" ones. This might not matter too much with some people. But ultimately the structure and function of the brain cells themselves is what matters, and the signaling that changes brain cells for the better is far downstream of serotonin receptors. In other words the real benefit of an SSRI is not some acute mood boost that most people are expecting from having more of their "happiness chemical", its from the brain cells responding to the increased serotonin signaling and changing their structure and function because serotonin signaling affects gene expression etc. So the benefits of SSRIs may not have as much to do with serotonin binding to serotonin receptors and altering neurotransmission acutely, but rather its probably more to do with serotonin receptors signaling to change brain cells fundamentally. Although that is specifically for what we know about depression, LTCs are pretty unusual lol. I hope that makes sense. Essentially its common for people to feel worse for weeks on an SSRI but that's supposed to get better. How long was your trial and what med at what dose Socrilus?
