Why take such high doses of MDMA? Your problems do make sense given you’re prescribed is a serotonergic (among other things) drug. My guess would be that you’ve done some hopefully only short term damage to your serotonin and possibly other receptors which only time can heal. I think you’d be better off switching to another sleeping med that doesn’t impact serotonin receptors, at least temporarily. If you tell your doctor it’s not working and you need high doses which you can’t tolerate, hopefully he will give you something else, at least a z-drug. Have you ever tried going a few days without taking any quetiapine at all? Given its complex mechanisms of action I’m concerned that it might be inhibiting your healing. If you could be on nothing at all for several months while you focus on optimising your health that would likely be ideal. If that’s not an option because of severe insomnia, then I would use a GABAergic drug, as minimally as possible - if possible, no more than every third night, for a few months. But I really need to know more about why you’re taking it to begin with and how bad your insomnia is.
