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MDMA Nuerotoxicity. Ways to Prevent It!

MMMMKAY?!

MMMMKAY?!

Ex-Bluelighter
Joined
Jul 28, 2010
Messages
489
Would St. Johns Wort help? (I've only found mixed reviews/posts on it which is why I'm starting this thread. I've actually found mixed reviews/posts on all of this stuff)
What about chlorpheniramine maleate?
What about Vitamin C
What are some good antioxidants for the nuerotoxicity?
And I know SSRIS can help.
 
Vitamin C is good (maybe even a multivitamin). Green tea extract is good source of anti-oxidants (or include natural sources in your diet, e.g berries). Not sure how much SSRIs help in the long run tbh... they seem to cause more trouble than good from what I've read.
 
Stay away from all of that shit.


Maybe just some simple antioxidants and a healthy diet. A good amount of vitamin C AFTER your roll can be helpful in neuroprotection. As long as you are taking ample breaks and reasonable doses there should be no reason for additional drugs.
 
Folley said:
Stay away from all of that shit.


Maybe just some simple antioxidants and a healthy diet. A good amount of vitamin C AFTER your roll can be helpful in neuroprotection. As long as you are taking ample breaks and reasonable doses there should be no reason for additional drugs.
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I disagree. Numerous people have come to the consensus that taking a quality SSRI (like sertraline or escitalopram) post-roll can negate all those nasty oxidative stressors that come on as a result.
 
Isn't prozac supposed to be neuroprotective if you take a dose the day after rolling? I can't quite recall, is that total bullshit? I hardly roll anymore, and can't recall.
 
Isn't prozac supposed to be neuroprotective if you take a dose the day after rolling?
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i highly doubt that. i wouldnt take prozac if i was paid too, its nasty stuff. doctors prescribe that poison like candy yet MDMA and coke are illegal. i dont see the logic. :|
 
"The Prozac Misunderstanding

There are also some 'exotic' neuroprotective regimens using prescription drugs. SSRIs such as Prozac or Paxil can protect against neurotoxicity by preventing access to the inside of the axon. However, these drugs also partially block MDMA's effects. There has been a popular belief that taking an SSRI like Prozac up to six hours after taking MDMA can prevent any neurotoxicity from occurring. This is untrue. Here's a graph from the research that inspired this idea:

[32]

The height of the bars indicates how much serotonin each test group's brains had one week after the experiment. Lower levels of serotonin indicate neurotoxicity has occurred (since serotonin is made by and stored in the serotonin axons.)

Although giving the rats Prozac (fluoxetine) up to six hours after the MDMA prevented some of the damage, it was only a partial solution. Even at three hours, significant damage appears to have occurred. If there were reason to believe that somebody was beginning to suffer neurotoxic damage (high dose, heatstroke) an SSRI might be an effective 'rescue' medication to limit the extent of the damage. However, because 'post-loading' with an SSRI is only partially effective, I am of the opinion that the first line of defense against neurotoxicity should be to prevent the 'neurotoxic scenario' from happening in the first place through moderation and preventing overheating. Antioxidants are more practical then SSRIs since they can be taken in advance (providing some protection from the start) without interfering with the desired MDMA high (as an SSRI would.)

A more radical approach is the use of the MAOI L-Deprenyl (Selegiline), which has proven to be extremely effective in preventing MDMA neurotoxicity in lab animals and does not interfere with MDMA's desired activity. In theory, Deprenyl is arguably the most potentially effective neuroprotective regimen, but more work needs to be done before any substantive statement on safety can be made. Several users have reported taking Deprenyl before MDMA with little or no effect (one user reported that Deprenyl made the MDMA dose uncomfortably 'speedy'.) In order to use Deprenyl as a neuroprotectant, a moderate dose (perhaps 5 mg) should be taken before the MDMA. This combination may prove to be quite dangerous! People experimenting with it should be medically knowledgeable and have a support system in place to provide immediate emergency medical attention if a problem arises".- http://thedea.org/neurotoxicity.html
 
Morphling said:
Isn't prozac supposed to be neuroprotective if you take a dose the day after rolling? I can't quite recall, is that total bullshit? I hardly roll anymore, and can't recall.
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Yes. It will block the reuptake of DA into the wrong 5-HT synapses.

Folley said:
Most people don't have access to a single dose of an SSRI however, and getting a prescription for one day makes no sense.
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Most people, however, have a friend who is prescribed. I think there are what? 100+ million SSRI users?...
 
MrSpeedyG said:
http://www.ncbi.nlm.nih.gov/pubmed/10619665

Alpha Lipoic Acid... If I dont have it I won't touch amphetamines, I don't roll anymore but if I did I won't do it with ALA.
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If yu don't mind me asking, what was your reason for quitting rolling?
I'm thinking of quitting it.
And that ALA stuff is easy to get huh? Like atta vitamin store?
And I take 70mg dexedrine a day (amphetamine) should I take ALA for it
 
Wow I read that article on ALA and it said it completely blocked or got rid of the serotonin deficienty. This seems too good to be true o:
 
The thing is a decrease in serotonin is not the same thing as neurotoxicity. 5-ht takes a long time to replenish compared to other neurotransmitters like dopamine so a lower level at one week does not indicate neurotoxicity. Look at similar 5-ht releasers like MDAI. MDAI releases large amounts of serotonin but is not neurotoxic because it does not produce the toxic metabolites(such as a-methyldopamine) that mdma does.

While an ssri post roll will certainly help block the toxic secondary metabolites, it doesn't prevent their formation like selective MAO-B inhibitors do. They would not be quite as good unless you took it in the middle of the experience which would kill the effects. Another possible thing to look into is COX inhibitors like naproxen. It appears that this may also prevent the formation of the toxic metabolites, though more research is needed to confirm this hypothesis.
 
MMMMKAY?, in answer to your question... Where to start is really, first and foremost that MDMA is a serotonergic neurotoxin and any ignorant dick that says otherwise I feel sorry for you, not to get into an argument that resposible use is safe blah blah blah majority of times resposible use never happens. Theres a ton of reason but obviously it is what MDMA does to your body/brain, both short and long term I mean literally where to start, what really got me to stop is the long term comedown that came after continuous rolling, but that really only opened ym eyes to the damage. If you would like to stop rolling, have a search around the ecstasy forum here and read some long term comedown posts alternatively.

70mg dexedrine a day is a solid amount assuming it is for ADHD... Yes ALA is something I would supplement with that personally.

As the poster above said, neurotransmitter depletion/receptor downregulation isn't neurotoxicity rather temporary as neurotransmitter stores are regenerated and receptors do reupregulate back to normal - neurotoxicity would be neuron destruction. I'm not really one for SSRIs after MDMA to block neurotoxicity, never done it but its better than nothing I guess. Keeping your doses responsible, taking safe measures ie staying cool, hydrated, and obviously antioxidant intake will help though!
 
There are ways to prevent some toxic damage. But if you are taking a recreational dose of MDMA, you are always causing some damage regardless of how many anti oxidants you are on.
If you are trying to double up on anti oxidants to reduce the amount of time you can wait to roll, you are only cheating your self. The damage will show itself soon enough, there is only so much you can do to protect your self from a potent neuro toxin like MDMA. Especially when people are taking multiple doses in a night. If i would have known better when i was rolling i would have made sure to never redose more than once.
 
laugh said:
i highly doubt that. i wouldnt take prozac if i was paid too, its nasty stuff. doctors prescribe that poison like candy yet MDMA and coke are illegal. i dont see the logic. :|
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That is because SSRI's are very gentle drugs. When you are on them you don't even notice them working, they just make negative thoughts go away. And getting off them was a cake walk for me, i suffered no extra depression when i came off zoloft (just a little dizziness).
How ever with moderate use of MDMA, i noticed negative effects in all sorts of brain activity that lasted months and months.

I don't know why you call SSRI's poison, MDMA is much more of a poison than they are.
 
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