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MDMA + Moclobemide = Somnolence?

Z

zouloum

Greenlighter
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Nov 25, 2011
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I want to preface this by saying that you should not try to mix these substances if you are not completely aware of the risks (Serotonin syndrome, seizures, etc) and are not 100% sure of what dose of MDMA you're taking (Mystery pills or powder could very well kill you with this combo).
Moclobemide will potentiate MDMA to the extent where seizure and death could happen at what is considered normal MDMA doses.

So I've tried MDMA (10mg) and moclobemide (150mg & 300mg [On separate occasions]) and both times, I've noticed some very strong somnolence.
This seems strange, as on their own, both of these drugs are known to cause insomnia.

I was wondering if anyone knows the cause of this.
Could it be because MDMA releases serotonin into the synapses and MAO-A can't destroy it so more of it is left to be metabolized into melatonin?
Also, is 10mg enough to reverse the flow of the SERT or does it only act as a reuptake inhibitor at such a low dosage?
 
Why are you combining MDMA and a MAOI in the first place? Do you have a death wish?

Off the top of my head, maybe MDMA is acting more of a 5ht1a agonist than a serotonin releaser. Maybe it is only releasing 5ht and not the other two monoamines (NE/dopamine). Maybe it is something entirely else.

Either way, further experimentation would be very risky.
 
sekio said:
Why are you combining MDMA and a MAOI in the first place? Do you have a death wish?

Off the top of my head, maybe MDMA is acting more of a 5ht1a agonist than a serotonin releaser. Maybe it is only releasing 5ht and not the other two monoamines (NE/dopamine). Maybe it is something entirely else.

Either way, further experimentation would be very risky.
Click to expand...
The dose makes the poison. How is it more dangerous than any other drug that you can overdose on? As long as the active dose is titrated up to and you're properly weighing the substances I don't see how it's any more dangerous than ANYTHING else that has a good chance of killing you with too strong of a dose.
 
Often, when I'm coming up on E, I get very sleepy and even start yawning and nodding off. I usually have to go for a walk or stay active and then the engery comes through.
If I'm just sitting around waiting for the E to kick in... I find it very relaxing and even sedating during the come up.
 
My first thought when reading the title of the thread was "MDMA + Moclobemide = DEATH", so I am glad to see you are talking about small doses here. I was hoping I wasn't about to read a horror story that could have easily been prevented.

All that aside, I have been curious about this for some time myself. My thought always was that you would be looking at a very different effect profile with such a combination. It would seem to me that you would not reach a high enough concentration of the compound, even with an MAOI to achieve the typical effects, and if you did you would really wish you hadn't. I'm interested, besides the desire to sleep, what other sort of effects did you notice when doing this combination? Did you notice any sort of stimulating effects under the somnolence? How about empathic qualities? Did you find the combination particularly 'enjoyable' or 'recreational', or was the second trial just in the name of science/curiosity?

I'm sorry that I cannot offer a 'why' for the paradoxical somnolence, but I would like to add that, like Ballz_Trippington, I too have encountered a very strong desire to sleep during the beginning of MDMA experiences, although it doesn't happen every time. One time in particular, when in my foolish youth I did a VERY large line of MDMA (seriously, like we're talking a line the width of your pinky that spiralled tightly from the outside edge of a dinner plate to its centre, maybe half a gram or more :S) I was wiped out for the first hour or so of the experience. After vomiting over the balcony onto the heads of people showing up late to our get-together, I proceeded to collapse into a chair and nod off for 30-45 minutes, while having the most vivid sexual dreams you can imagine. It turns out the sex dreams happened because apparently a few girls mistook my unconsious form for a sextoy and proceeded to do things to me while my conscious mind was elsewhere. Anyway, after I came to and extricated myself from the writhing naked bodies all over me, I proceeded to vomit again, and then the stimulation hit. I was unable to even think of sleep for a good 16 hours after that 'heroic' (see: retarded) dose.

This was the most severe sedation I have ever encountered from MDMA, but it has happened other times as well. I would be interested to know the mechanism behind this.
 
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As long as the active dose is titrated up to and you're properly weighing the substances I don't see how it's any more dangerous than ANYTHING else that has a good chance of killing you with too strong of a dose.
Click to expand...

Of people reporting back experiences after reading my combination of stimulants and selegiline thread, I've heard of none who titrated upward sufficiently safely.

ebola
 
I apologise for the double post, it seemed that no one was going to move this thread from the Ecstasy board to this one.

The experience was very strange to me, and my memory of this event (which happened a few months ago) is very cloudy.
At first, it was slightly stimulating (maybe in anticipation to the result of my experiment), but then my alertness level rapidly dropped (it greatly diminished the symptoms of my Generalized & Social Anxiety Disorder) and the stimulating effects faded.
I felt quite relaxed on a "peripheral level" (the Sympathetic nervous system perhaps?) to a point where I felt a bit weak (somewhat similar to someone having a rough(as in hard to get out of bed) wake up).
I can't really speak for the entactogenic properties of the experience as I was alone, but if I had company I feel like I would've been in a cuddly mood.
During most of the experience I felt the need to lay in my bed in a state that I can only describe as feeling as though I was awake, but at the same time having just been pulled out of deep sleep during the entire duration.
During this, I even managed to fall asleep even though it was 6 PM (18:00) and I have delayed sleep phase disorder.
In retrospect, I'd say that it was quite enjoyable, more so than MDMA alone, perhaps because I dislike the stimulating properties of MDMA.
 
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