MDMA + MAOI = I have questions

[Vildail]

Ive been doing a lot of reading and I guess im still a bit confused.
I would like to start by saying this is not a combo I will ever try... I have thizzd plenty and I am done. It started to feel like chasing the dragon and I decided that im done. But how the chemicals interact with your brain is fascinating to me.

Question 1:

It sounds to me like Serotonin syndrome is at least partially prevalent whenever you roll... A lot of the symptoms described I have experienced while rolling I.E. sweating, dilated pupils, myoclonus (intermittent tremor or twitching), as well as overresponsive reflexes. It seems that only extremely severe cases of Serotonin syndrome can cause your unfortunate and untimely demise. So I guess its less of a question and more me asking if what I just said sounds retarded or if im on the right track.

Question 2:

Other than dopamine breaking down into hydrochloric acid, is there any other neurotoxicity that takes place after rolling? (I ask question 2 to ask question 3)

Question 3:

If the MAOI's are disabled then that should prevent the dopamine from breaking down and in theory would prevent all neurotoxicity that would have normally occured during the roll.

(As we all know e is dirty and has all kinds of goodies mixed in with the MDMA.)

Question 4:

Would any of the following effect the MAOI's in any way: Meth, Coke, Ketamine, Heroin.

 

[Qnick]

With an MAOI in your system, your body will not be able to break down monoamines like serotonin and dopamine. My understanding is that this would cause more damage to neurons by preventing them from being cleared out. It would *cause* serotonin syndrome.

also, combining meth with an MAOI would probably do quite a bit of damage

 

[Vildail]

"also, combining meth with an MAOI would probably do quite a bit of damage" Would you elaborate please? Also im asking about the other hard drugs simply because I have had thizzles with meth, coke, and sometimes multiple drugs at one time. (those are the best! PEACH KEYS! lol... once upon a time)

 

[seep]

If the MAOI's are disabled then that should prevent the dopamine from breaking down and in theory would prevent all neurotoxicity that would have normally occured during the roll.

I wonder if anyone has died by confusing the monoamine oxidase enzymes with MAOIs, as so often I hear the phrase "MAOI inhibitor"; without abreviation, this means monoamine oxidase inhibitor inhibitor. One can imagine what would happen to someone taking an MAOI with the intention of preventing monoamine oxidase inhibition.

 

[Qnick]

"also, combining meth with an MAOI would probably do quite a bit of damage" Would you elaborate please? Also im asking about the other hard drugs simply because I have had thizzles with meth, coke, and sometimes multiple drugs at one time. (those are the best! PEACH KEYS! lol... once upon a time)

MAOI's change the way your body processes many chemicals. With an MAOI your body wouldn't be able to properly metabolize the meth, or the extreme amounts of dopamine released.

Taking a drug after crippling the metabolic pathways your body has in place to clear the drug out of your body is not a good idea.

combining E with other stimulants is a whole different game than combining anything with an MAOI

 

[psood0nym]

Selegiline at a low MAOB inhibiting dose is the only one that I've heard of people combining with MDMA repeatedly. I'm not sure if it helps or not. Non-selective MAOIs are much more dangerous.

Regarding meth, I came across this abstract of an assessment of IV meth safety during selegiline treatment. It was kind of surprising because I've read a lot of posts here about how dangerous combining it with amphetamines is supposed to be (I'm sure it's more dangerous for some amphetamines and less for others). For the study they were using 15 and 30 mg IV doses of meth. Higher doses may have been different. It only slightly increased reports of adverse events. I tried phenethylamine with selegiline a few times and with 120 mg phenethylamine taken incrementally over an hour my blood pressure was raised enough that I started to feel my pulse in my face. Selegiline is not worth the worry of using it in my opinion.

The principal finding from this study was that intravenous administration of moderate doses of methamphetamine was safely tolerated during treatment with selegiline. No participants had electrocardiogram changes, and there were no meaningful differences in any laboratory values either between groups at screening or as a result of the study procedures. In general, adverse events were mild or moderate, and no subjects were discontinued due to adverse events or serious adverse events. Selegiline treatment did not enhance any of the cardiovascular changes (heart rate, blood pressure) produced by methamphetamine administration.

 

[ebola?]

Anecdotally, people have had really bad luck with non-selective MAOIs (duh). There have been cases of 5ht syndrome-proper, psychosis, panic, etc. It's also life-threatening.

It is unclear how dangerous selective inhibition of MAOB + MDMA is. Some people report an improved effect-profile as long as doses are adjusted downward. Others find it too stimulating. Others have had uncomfortable experiences (physical or mental). Anyone know if this combo's produced life-threatening symptoms w/ anyone before?

eh...I wouldn't combine enzyme inhibition with unknown street drugs. Some piperazines + selegiline could be disastrous, let alone something like PMA. And what if you get a 'bomb' pill with too high a dose?

ebola

 

[tathra]

i've taken mdma+harmaline. it was actually one of the best experiences i've ever had, but its not something i'd recommend others to try due to all the possible complications.

unfortunately i'm a bit too trashed at the moment to try to put any thought into answering your questions

 

[Azron]

I've had a good experience with aurorix (moclobomide - not availialble in US) and mdma. Although I highly recommend against it.... only cause of wat can happen,. I've heard some scary story's but fuck its the best high of my life so far....Maybe.
PLUR
Be safe

 

[Advanc3d]

I have also tried Moclobemide 150mg 40minutes before MDMA

Possibly the best peak without any negative side effects.

I think people fail to realise that reversable MAOI's sepcially this one very different to any other MAOI.

From what i read, moclobemide inhibits MAOI in a way where as once serotonin concentration reaches a centrain point (obviously higher than what it would be without the MAOI) then the enzymes would become effective again. though this is clearly dose related. so if you take 300mg before mdma, dont expect to have a good time (or live if your new to the scene)

I have personally been doing MDMA for the past 3 years on a frequent-occasional basis.
I have taken moclobemide many times with MDMA, BZP, and pretty much anything without any negative effects, excess sweating, hypertension...


I also have never ever had a problem with Selegiline, if anything the MAOI-A activity would be beneficial if taken at a high dose. i insufflate 1.25mg (only because this way im assured almost full inhibition)

p.s before anyone says anything, yes i know its dangerous. i study pharmacology, biochemistry, chemistry in university so i am not some random kid going around being stupid with MAOI's

 

[MeDieViL]

Is there any source where it has been shown that mao becomes active again when serotonin reaches high levels on moclobemide?