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MDMA &
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MDMA makes me want to sit down. Not rave.
- Thread starter whiteline
- Start date
I personally find MDMA to have less of a speedy push that it did 15 years ago, but i was a youthful 21 years old and had more of a spring in my step. Having said that I still find MDMA is a great drug to dance on. Start dancing before it hits you and when it does you'll not want to stop. A lot of folk wait for the MDMA to hit before cutting a few shapes, this can lead to folk just sitting chatting shit for hours...........its a win win in my opinion!
Will this post be deleted? Lots of post going missing from here recently.
Swedger77
Will this post be deleted? Lots of post going missing from here recently.
Swedger77
Folley
Bluelighter
^ The 5-HTP discussion was moved to the supplements thread, nothing was deleted
LonE1
Bluelighter
- Joined
- Jan 6, 2010
- Messages
- 674
Thats exactly why I hated taking straight mdma/molly at a rave...I would just chill. Seriously like, my favorite fucking DJ is up on stage, and im forcing myself to dance.
I always needed some pills cut with some amp....just made the night more enjoyable overall, even if the next day isn't LOL
Still worth it IMO back in tha days
I always needed some pills cut with some amp....just made the night more enjoyable overall, even if the next day isn't LOL
Still worth it IMO back in tha days
laugh
Ex-Bluelighter
Keep it simple stoopid and find a decent dj. Could be on smack and still rave so long as the tunes and set a d setting are good imo. Good luck getting sweaty 
Penthos
Bluelighter
I get this too. I find that if I'm dancing while I come up, I'll keep dancing. If I'm chillin', I'll keep on chillin' til' I come down. Staggering your dose over a longer period will help to keep you from getting floored, as said above. I usually take 125mg then an hour later another 50-75mg.
I also find that being a bit tipsy (like 3 or 4 beers, no more) before you drop helps keep you on the dance floor. Just be sure to switch to water after you drop
I also find that being a bit tipsy (like 3 or 4 beers, no more) before you drop helps keep you on the dance floor. Just be sure to switch to water after you drop
heerutosen
Bluelighter
It is more neurotoxic with caffein, but a 5 hour energy should be fine..
StrutterGear
Bluelight Crew
Why is it?
heerutosen
Bluelighter
By a higher increase in bodytemp and increase of dopamine from what i have read before and by enhanced glial activation suggesting potential facilitation of neurodegenerative processes.
I will look up some links
I will look up some links
Last edited:
heerutosen
Bluelighter
http://www.ncbi.nlm.nih.gov/pubmed/16889759
Although caffeine alone failed to alter body temperature, it potentiated MDMA-induced hyperthermia. This association also significantly increased MDMA lethality (from 22% to 34%). Following administration of MDMA to rats, there was a persistent decrease in the number of serotonin transporter sites in the cortex, striatum and hippocampus, which was potentiated by caffeine co-treatment. This MDMA toxicity in rats was accompanied by a transient dopaminergic impairment in the striatum, measured as decreased [(3)H]WIN35428 binding sites, by 31% 3 days after treatment, which was not modified by caffeine. A transient down-regulation of 5-HT(2) receptors occurred in the cortex of MDMA-treated rats, whose recovery was slowed by co-treatment with caffeine
http://www.wired.com/wiredscience/2008/02/caffeine-and-ec/
To test their theory, the scientists injected the drugs into Sprague Dawley rats and then probed them with a rectal thermometer. When the unlucky critters received both chemicals, their body temperatures increased far more than when they were given MDMA or caffeine alone.
Harkin and his team followed up with some very thorough work in an attempt to understand how the two chemicals interact. By giving rats a combination of caffeine and other drugs that have well-known effects on the brain, they were able to conclude that dopamine receptors, a type of nerve signaling protein, play a big role in the unusual overheating.
http://www.ncbi.nlm.nih.gov/pubmed/22671762
Co-administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality. In addition, co-administration of caffeine enhances the long-term serotonergic neurotoxicity induced by MDMA. Observations to date support an interactive model of drug-induced toxicity comprising MDMA-related enhancement of dopamine release coupled to a caffeine-mediated antagonism of adenosine receptors in addition to inhibition of PDE
http://www.sciencedirect.com/science/article/pii/S0014299906012490
Caffeine promotes hyperthermia and lethality when co-administered with the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) to rats. In the present study, co-administration of caffeine (10 mg/kg, s.c.) with MDMA (10 mg/kg, s.c.) induced a profound tachycardic response compared to rats treated with either drug alone. However, neither caffeine (30 μM) nor MDMA (1–30 μM), alone or in combination, affected the electrocardiogram of the isolated heart suggesting that central and sympathomimetic actions, rather than direct actions of these drugs on the heart, are responsible for the tachycardia observed in vivo. This is a serious drug interaction, which could have important health consequences for recreational drug users.
This is just a quick search, but i have read more about it in the past.. Including a slight potentiation when caffeine is taken prior to MDMA wich resulted in longer duration and increase of effects(and side effects)..
My guess would be to take the 5 hour energy in advance and take extra care to stay cool and hydrated.. Taking high dose caffeine pills seems like a bad idea to me now, i have done this in the past and have to admit i felt shittier after, even though i do believe it enhanced the overall experience.
My 2 cents
PS. I have not found any evidence of a human death resulting from co-administration of caffeine, but the fact that it does increase these dangers, will hopefully make you consider ditching the caffeine or atleast lower the dose.
Stay safe
Although caffeine alone failed to alter body temperature, it potentiated MDMA-induced hyperthermia. This association also significantly increased MDMA lethality (from 22% to 34%). Following administration of MDMA to rats, there was a persistent decrease in the number of serotonin transporter sites in the cortex, striatum and hippocampus, which was potentiated by caffeine co-treatment. This MDMA toxicity in rats was accompanied by a transient dopaminergic impairment in the striatum, measured as decreased [(3)H]WIN35428 binding sites, by 31% 3 days after treatment, which was not modified by caffeine. A transient down-regulation of 5-HT(2) receptors occurred in the cortex of MDMA-treated rats, whose recovery was slowed by co-treatment with caffeine
http://www.wired.com/wiredscience/2008/02/caffeine-and-ec/
To test their theory, the scientists injected the drugs into Sprague Dawley rats and then probed them with a rectal thermometer. When the unlucky critters received both chemicals, their body temperatures increased far more than when they were given MDMA or caffeine alone.
Harkin and his team followed up with some very thorough work in an attempt to understand how the two chemicals interact. By giving rats a combination of caffeine and other drugs that have well-known effects on the brain, they were able to conclude that dopamine receptors, a type of nerve signaling protein, play a big role in the unusual overheating.
http://www.ncbi.nlm.nih.gov/pubmed/22671762
Co-administration of caffeine profoundly enhances the acute toxicity of MDMA in rats, as manifested by high core body temperature, tachycardia and increased mortality. In addition, co-administration of caffeine enhances the long-term serotonergic neurotoxicity induced by MDMA. Observations to date support an interactive model of drug-induced toxicity comprising MDMA-related enhancement of dopamine release coupled to a caffeine-mediated antagonism of adenosine receptors in addition to inhibition of PDE
http://www.sciencedirect.com/science/article/pii/S0014299906012490
Caffeine promotes hyperthermia and lethality when co-administered with the recreational drug 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) to rats. In the present study, co-administration of caffeine (10 mg/kg, s.c.) with MDMA (10 mg/kg, s.c.) induced a profound tachycardic response compared to rats treated with either drug alone. However, neither caffeine (30 μM) nor MDMA (1–30 μM), alone or in combination, affected the electrocardiogram of the isolated heart suggesting that central and sympathomimetic actions, rather than direct actions of these drugs on the heart, are responsible for the tachycardia observed in vivo. This is a serious drug interaction, which could have important health consequences for recreational drug users.
This is just a quick search, but i have read more about it in the past.. Including a slight potentiation when caffeine is taken prior to MDMA wich resulted in longer duration and increase of effects(and side effects)..
My guess would be to take the 5 hour energy in advance and take extra care to stay cool and hydrated.. Taking high dose caffeine pills seems like a bad idea to me now, i have done this in the past and have to admit i felt shittier after, even though i do believe it enhanced the overall experience.
My 2 cents
PS. I have not found any evidence of a human death resulting from co-administration of caffeine, but the fact that it does increase these dangers, will hopefully make you consider ditching the caffeine or atleast lower the dose.
Stay safe
Folley
Bluelighter
It is NOTHING compared to adding an amphetamine into the mix.
I'd recommend a 5 hour energy... NOT pure caffeine. They have extra B vitamins and nutrients to give your body fuel it needs to make energy the natural way
TheJasnSensation
Bluelighter
Well put!:D
TheJasnSensation
Bluelighter
LSD and the MDMA help keep me going at a show
Glad to see this post, def something ive noticed myself. I deal with alot of first time rollers, prob have delt with 20+ first time rollers kinda my thing. My advice to anyone new to rolling or even those not expierenced is that you dont need to be afraid of taking a break to chill. You may feel like all you want to do is sit and chill but if you are coming up hard go sit and relax for 30 mins get up and rage. So many people feel the need that they need to go hard the entire time they dont end up enjoying the expierence to its potential. Id rather give up an hour of my night sitting and relaxing to truely enjoy 4 hours than have 5 hours of an "ok" time.
laugh
Ex-Bluelighter
heerutosen yous is a good poster. keep up the good work mate!
AbsintheKittie
Bluelighter
I think it has a lot to do with set and setting as well as energy levels..
I have found that I can just as easily stay home with someone, or a small group of friends and chill on MDMA and never want to get up and dance ect... OR go out to a show and dance for 5 hours straight never sitting down..
(That's out of the norm for me BTW. I have issues that do not allow me to be overly active a lot...I have wonderfully had the added benefit of pain reduction from MDMA )
Ether case.. I have found that a 5 hour energy does seem to help.. and something like a AMP or Monster can leave me feeling "buzzy" or edgy.. I would guess that comes from the caffeine.. I now only do the 5 hour energy with MDMA..
.....not related to the OP but what others in the thread have said.... I think the massive thing that is over looked when people start talking about MDMA, the after effects, Damage and long term issues...Is that everyone's brain is different to start with. YES, we are all human and have the same basic make up.. but not everyone has the same chemical levels to start with.. Someone who is prone to depression on their own is going to have a NASTY bout of depression among other issues and maybe only after one night with MDMA at that.. over time they will level out but due to their brian already making the chemicals that keep us from being depresses at a slower rate it takes them longer.. THAT IS NOT MDMA's fault.. that is faulty brian chemistry.
That is why some of "us" have been able to party hard at times, in the past ect.. and no have those nasty side effects...Your brian is healthy OR maybe you produce very high amounts of chemicals on a daily basis.. I have seen those people who can roll for three nights in a row and then again the next weekend and other then a bit of a body load are fine and don't show any wear or tear for it.. While I have seen a guy take ONE 120mg dose and it RUINED his month..
PEOPLE need to take into account their own body chemistry FIRST, then take into account what they are taking and how much.. I think it is unfair to blame MDMA for all of the things people blame it for.. YES some things brought on by it, I am not saying that it does not come with its own bag of horrors.. IT DOES.. I am saying that Chemistry should be a thought first and finding out how someones ONGOING mental state is before blaming MDMA for the issues..
It's "recommend" to space your rolls... will it kill you if you roll too soon back to back once in a blue moon? NO, but you should understand that doing so you ARE going to pay the price on the back end.. Maybe you are that person who can roll every weekend and not have issues ONE DAY you will.. Nothing last forever... YOU are ageing everyday.. Your Body Changes everyday.. What you could do a year ago and not have negative effects from, you may not be able to do today.. and what you can do today you may not be able to do a year from now.. EVERYONE needs to do a personal check of them selves before rolling or partaking of any substance for that matter and ask them selves, how am I doing? Am I balanced? Know your self, Know your Substances..Or they will OWN you!!!
I have found that I can just as easily stay home with someone, or a small group of friends and chill on MDMA and never want to get up and dance ect... OR go out to a show and dance for 5 hours straight never sitting down..
(That's out of the norm for me BTW. I have issues that do not allow me to be overly active a lot...I have wonderfully had the added benefit of pain reduction from MDMA )
Ether case.. I have found that a 5 hour energy does seem to help.. and something like a AMP or Monster can leave me feeling "buzzy" or edgy.. I would guess that comes from the caffeine.. I now only do the 5 hour energy with MDMA..
.....not related to the OP but what others in the thread have said.... I think the massive thing that is over looked when people start talking about MDMA, the after effects, Damage and long term issues...Is that everyone's brain is different to start with. YES, we are all human and have the same basic make up.. but not everyone has the same chemical levels to start with.. Someone who is prone to depression on their own is going to have a NASTY bout of depression among other issues and maybe only after one night with MDMA at that.. over time they will level out but due to their brian already making the chemicals that keep us from being depresses at a slower rate it takes them longer.. THAT IS NOT MDMA's fault.. that is faulty brian chemistry.
That is why some of "us" have been able to party hard at times, in the past ect.. and no have those nasty side effects...Your brian is healthy OR maybe you produce very high amounts of chemicals on a daily basis.. I have seen those people who can roll for three nights in a row and then again the next weekend and other then a bit of a body load are fine and don't show any wear or tear for it.. While I have seen a guy take ONE 120mg dose and it RUINED his month..
PEOPLE need to take into account their own body chemistry FIRST, then take into account what they are taking and how much.. I think it is unfair to blame MDMA for all of the things people blame it for.. YES some things brought on by it, I am not saying that it does not come with its own bag of horrors.. IT DOES.. I am saying that Chemistry should be a thought first and finding out how someones ONGOING mental state is before blaming MDMA for the issues..
It's "recommend" to space your rolls... will it kill you if you roll too soon back to back once in a blue moon? NO, but you should understand that doing so you ARE going to pay the price on the back end.. Maybe you are that person who can roll every weekend and not have issues ONE DAY you will.. Nothing last forever... YOU are ageing everyday.. Your Body Changes everyday.. What you could do a year ago and not have negative effects from, you may not be able to do today.. and what you can do today you may not be able to do a year from now.. EVERYONE needs to do a personal check of them selves before rolling or partaking of any substance for that matter and ask them selves, how am I doing? Am I balanced? Know your self, Know your Substances..Or they will OWN you!!!
heerutosen
Bluelighter
heerutosen yous is a good poster. keep up the good work mate!
Haha.. Thanks i'll do my best!
heerutosen yous is a good poster. keep up the good work mate!
Yeah good posts nicely reference with scientific articles. Like when statements are properly backed up with scientific papers. This forum needs more of this and less of the usual hearsay and bullshit.