MDMA doesn't work on me

[Foreigner]

If I take pure MDMA by itself, I get the peak for about 20 minutes and then the high just completely flatlines. It's like someone flipped a switch and I'm sober again. I can pinpoint it down to the very moment it happens, it's so strange. And yes, this is confirmed MDMA, not a fake, and I am not on SSRIs or anything that would be blocking it. I've done the same batches as my friends from a trusted source and they are all high as kites while I'm not getting anything.

Paradoxically, if I take MDMA with LSD, ketamine, or MDA, I feel the MDMA for a lot longer. It's like I need another "carrier" drug to make MDMA really happen. You would think MDA wouldn't make a difference because they are from the same family, but it makes a huge difference.

I would just write this off as something to do with my liver enzymes, except that when I used to rave in my late teens/early 20's, I would do E regularly and get very high from it. The only thing is, I bought it from random dealers at the events so there's no way to know if I was taking genuine MDMA or not. It usually had that tell tale euphoria though. Yet now, as I approach 30, if I do MDMA it basically doesn't work.

To this day I have not received a good explanation for this.

I've had my genetics tested and my CYP2D6 enzyme (the one that processes MDMA/mushrooms/ketamine/LSD) behaves a little strangely. But you have that from birth, so if MDMA isn't working now then it shouldn't have worked all along.

In my early 20's I suffered from suicidal levels of depression from all my MDMA use and ended up taking an SSRI. Could it be possible that somehow, post-recovery, my serotonin tree is now reconfigured differently so that MDMA cannot interface with it like it used to?

 

[Mr.MDxx]

One explanation that pops into my head is maybe you have just lost the magic. As you said you had "suicidal levels of depression" from all the MDMA you took. How long did you wait between rolls? What was your average dose? Did you often redose?

That's just one explanation, could be right, could be wrong. Hope this helps.

 

[laugh]

sounds like clean stuff. i know when its good gear i used to be quite a bit like that too. i used to find if dropping/eating i would get an alert, then between 3 & 4 waves that would build until the jaw orgasm, eye wobbles floored me for between 20-50 minutes, as soon as i had the thought im coming too again it would be like another 5-10 minutes and i felt pretty much back to baseline. Md punches hard but is way short lasting, especially if its clean. this led to me re-dosing way way to many time in a night and eventual burnout. i was snorting a solid dose to get on point quick and at the same time dropping so that when the lines wore off id be coming up strong from the shit i ate, greedy double-ups...i used to do this throughout the night way too much...this led me to enjoying md with pipe cause the pipe just kept me going strong no matter what...pipe and md is not a healthy mix imo...last time i tried that combo felt like my heart was gonna jump out of my throat...not to mention losing half my body wait through perspiration...good times haha

 

[Foreigner]

One explanation that pops into my head is maybe you have just lost the magic. As you said you had "suicidal levels of depression" from all the MDMA you took. How long did you wait between rolls? What was your average dose? Did you often redose?

That's just one explanation, could be right, could be wrong. Hope this helps.

When I was younger I was rolling every single week. I was a 9-5er who lived for my weekends. My life was sort of like something out of a movie... working in a shitty, souless office from Mon-Fri and then partying my face off on the weekends. Every time I went out on weekends to go dancing I'd roll, sometimes with 2-3 pills. I went a good 7-8 months of that routine until finally my immune system collapsed and I got so sick I was in the hospital for a few weeks.

If it's genetic/enzyme based, it doesn't make sense that MDMA would work on me then but not now. I know that some E I took was surely not MDMA since it was always obtained at the events from random people, but at least part of the time it was. So the only reason I can think of that it worked then but not now is that my serotonin tree suffered some major trauma and the way it healed made it incompatible with MDMA. Or maybe the recovered system is just very sensitive to overload now, so that if I take MDMA the receptors down-regulate quickly. It would also explain why slightly different molecules, like MDA, work on me. I never did MDA back then.

Other than that theory, I've got nothing.

 

[Sen5i]

if you took mdma alot, you have lost the magic i have been starting to (before i quit due pregnancy)
id feel up but no love, no rush no nothing really just abit spangled. whilst friends was loving life..
take a break, or theres a certain vitimin you can take health shops (not for tht) but to help your seritonion.. get abit better,
or if you have had a long episode of taking Mephedrone, that sometimes affects the way MDMA affects you.

 

[Sen5i]

i wouldnt sugest taking the vitimin and mdma on the same day, this is just while your recovering!! ;P just incase.

 

[Foreigner]

^ I do MDMA once a year now, if that. Still nothing.

 

[Clocktower]

Could it be possible that somehow, post-recovery, my serotonin tree is now reconfigured differently so that MDMA cannot interface with it like it used to?

Could be.