MDMA brain damage

[nuke]

^So would this mean psychedelics + MDMA would be more neurotoxic because of the added 5-ht2A/C activation?

Yup. This is why MDA is more toxic than MDMA.

 

[stormyweathers]

For single, recreational doses (read: no binges, no repeated use within short time!) neurotoxicity could not be confirmed for MDMA to my best knowledge.

Heavy use is harmful beyond any doubt!

- Murphy

do you have a source for this?
I know it seems intuitive, but I'd rather be sure if possible

by short time do you mean a month? two months? 3?

 

[atara]

http://www.maps.org/news/neurotoxfaq.html

Note that recreational MDMA preparations (be they pills or powder) often contain methamphetamine! When considering a reasonable use pattern, assuming your ecstasy or molly is pure is dangerous.

 

[stormyweathers]

of course of course
I was wondering hypothetically about specifically MDMA and other MD analogues
to settle an argument between friends

 

[thelearner]

Yup. This is why MDA is more toxic than MDMA.

Shit. So my intended 2C-I + MDMA adventure this weekend is likely to be a real battering...bummer.

I've also ordered some selegeline, due to arrive tomorrow, as an adjunct to MDMA consumption (low, single doses + much lower MDMA dosing) to prevent neurotoxicity, but know that its use with 2C-X compounds is strongly recommended against since MAO-B breaks that down.

I don't suppose anyone here thinks that a 2.5mg single dose of Deprenyl + 1 "MDMA" pill + 5mg 2C-I would be a safer option (from a neurotoxicity perspective) than dropping the Deprenyl entirely and increasing dosage to more like 2-3 pills, 20mg 2C-I? Either way, COPIOUS amounts of antioxidants will be consumed.

 

[pofacedhoe]

http://www.maps.org/news/neurotoxfaq.html

Note that recreational MDMA preparations (be they pills or powder) often contain methamphetamine! When considering a reasonable use pattern, assuming your ecstasy or molly is pure is dangerous.

this depends on what country you are living in, uk pills almost never contain methamphetamine AND mdma often being mdma or rarely meth bombs (i have these once and they blew my head off).

amphetamine and mdma left me with brutal suicidal comedowns that were ten to fifty times worse than mdma on its own

 

[pofacedhoe]

Shit. So my intended 2C-I + MDMA adventure this weekend is likely to be a real battering...bummer.

I've also ordered some selegeline, due to arrive tomorrow, as an adjunct to MDMA consumption (low, single doses + much lower MDMA dosing) to prevent neurotoxicity, but know that its use with 2C-X compounds is strongly recommended against since MAO-B breaks that down.

I don't suppose anyone here thinks that a 2.5mg single dose of Deprenyl + 1 "MDMA" pill + 5mg 2C-I would be a safer option (from a neurotoxicity perspective) than dropping the Deprenyl entirely and increasing dosage to more like 2-3 pills, 20mg 2C-I? Either way, COPIOUS amounts of antioxidants will be consumed.

dont mix the deprenyl with what is already going to be a powerfull combo, just accept that this combo is a thing to do very rarely.

over a month ago i had 40mg of aMT , now i could tell for the week after that i was snappier and had less patience which is why rather than worrying about this i'm just not going to do it very often...