• N&PD Moderators: Skorpio

mdma bioavailibity

There aren't, it seems.

Oral BA is variable based on dose. Bigger doses are better absorbed.

Given that a "good oral dose" is considered to be about 120mg, and comparable injected doses anecdotally are about 25-50mg, that means it's probably something like...

oral: 30-60%
nasal/rectal: 60-80%
 
Lots of drugs have higher BA via non-oral routes, because orally administerred medications have to be processed by your liver before they make it into your blood, resulting in a loss of drug.

Anecdotally, most people who do nasal/rectal MDMA report they have to use less than they'd use if they did it orally.
 
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