MDMA and SSRI's?

[ComedownsSuck]

So I have 2 rolls left over from a concert i went too a few days ago, and a girl i work with has been telling me she wants to give rolling a shot, so today i asked her if she wanted to roll with me tomorrow. The rolls i have are some of my favorite rolls that i have ever came across and have tested to be pretty clean.

While talking to her, she told me that she takes Lexapro (escitalopram oxalate), and that the last time she took it was at 8 a.m. this morning. We plan on taking the rolls at about 1 p.m. tomorrow, and she wont take any Lexapro tomorrow morning.

From what i've read, she may not feel the roll as much due to the Lexapro. Would this still be the case even though there will be about 29 hours in between her last dose and the roll? Would there be anymore risk for her then anyone not on drugs such as Lexapro to take the roll? Is there an increased chance in fatal consequences if she takes the roll?

 

[Folley]

Bro, don't be a dick and try and force some pills down her throat... she's on anti-depressants, she should not be taking MDMA.



Not only will she not feel the positive effects of the drug, but it could set her medication back and is potentially quite dangerous. If you care about her for anything more than her boobs, you'll skip rolling for her sake and find something you can both enjoy. I know, it sucks.. but when someone is on powerful medication like SSRIs you need to respect that and put their best wishes first. I'm sure you'll do the right thing, and if you explain to her that it's for her own good I'm sure she will think quite highly of you for putting her safety before your penis

 

[ComedownsSuck]

Bro, don't be a dick and try and force some pills down her throat... she's on anti-depressants, she should not be taking MDMA.



Not only will she not feel the positive effects of the drug, but it could set her medication back and is potentially quite dangerous. If you care about her for anything more than her boobs, you'll skip rolling for her sake and find something you can both enjoy. I know, it sucks.. but when someone is on powerful medication like SSRIs you need to respect that and put their best wishes first. I'm sure you'll do the right thing, and if you explain to her that it's for her own good I'm sure she will think quite highly of you for putting her safety before your penis

Thanks for the reply, but you may have taken what i wrote the wrong way. I am not trying to force her to do anything that she doesn't want to do. Before this past weekend, she has expressed to me that she would like to try rolling a few times. She has also expressed that she would like to try it for her first time with me or another co-worker of mine because she knows that we are both quite experienced with the drug, and she knows that she can trust us. By no means am i trying to be a dick, or trying to intoxicate her with the sole purpose of getting self pleasure out of it. I made this post concerned about her safety, and wanted to confirm research that i had already done.

 

[Folley]

OK, ok.. I might have been a bit hasty haha. I'm guessing she doesn't know or understand the interaction between the drugs though, so if you're doing the research for her then good on you.

Really though, do stress to her that she shouldn't be doing this... it's just not something to play around with. She won't feel anything near as good as it should feel, and will likely be a disappointment all around.. at best. I'm sure you can find something else exciting to do, drugs or not

 

[WarChild]

I just posted this in another thread - i spent 3 years rolling whilst on SSRI anti-depressents and found i could still roll but took a bit more (2 pills at once as a rule). I realy don't know how safe it is though, in terms of the interaction..... be safe!

 

[edmgirl]

I was on Lexapro 20mg for about 2.5 weeks. The day that I rolled I did not take the Lexapro. The effects of the roll were greatly decreased. All I really experienced from the roll was a bit more energy and friendliness than normal. I also had a hard time falling asleep and my pupils were pretty dilated. I realized that the Lexapro was not out of my system long enough for the roll to have full effects. I plan to roll again pretty soon and this time I will have not taken the Lexapro for 7 days. Hopefully this is a long enough time period!

On a side note, many people say stopping your anti-depressant cold turkey will cause very bad withdrawal symptoms. This did not happen to me, however, I was only on the medication for 2.5 weeks and I also never received any side effects when I began the meds. I believe withdrawal symptoms vary from person to person and also depend on how long you've been taking the medication. Also, I was diagnosed with a very mild case of depression so it's possible I don't really even need to be on meds.

 

[Torresmo]

I have been researching about this, since my gf takes lexapro.
There is a discussion about it in the "dangerous combos thread" and basically, from what a i read there, the combination mdma+ssri is not dangerous, but indeed you may not feel the full effect.
In NYE my gf was taking 10mg only, and as I didnt know it was safe (wikipedia says it might be a dangerous combination) I gave her only 70mg. She isnt very experienced but didn mention any decrease in the effects... Actually, we had a really great night!
Now shes taking 30mg (!) and since this increase in the dose we hadnt tried any serotonergics. However if she forgets to take her daily dose for 1 day she feels really REEEALLY bad!
So i would advise her: its ok to take mdma, but DONT SKIP YOUR DOSE!
The effects may be diminished but its better than stop taking lexapro. Imagine the comedown combined with an ssri withdrawal! Recipe for a trainwreck, IMO..

Edit: just now I saw this thread is rather old, lol...

 

[bees_knees]

What about considering that MDMA leaves you depressed for 2 weeks / depletes serotonin, and she's obviously already got serotonin / depression problems?