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Mdma And Anti-depressants - Mega Merged

Hi, my friend is prescribed to Cymbalta and Abilify to treat depression caused by PTSD. I really want her to try MDMA as I think it could be very beneficial for her, and might let her open up and get over some of the things that happened to her in the past. I would feel bad telling her not to take her medicine for an extended period of time because she often gets really emotionally fragile without it. How long do you guys think she would have to refrain from using her prescriptions before taking MDMA so that there would be no reduction in effects?

Wonderingly,
Oht
 
How long is a piece of string? It depends on how long she was on the anti-depressants, and at what doses. Plus there might be individual factors.

I would suggest that if she's been on the A-D's for several months or more, that it could take at least a month before she rolls properly.

In your friend's particular case, I would strongly advise against having her stop her medication: you say yourself that she gets "emotionally fragile" without it.

I do agree with you that MDMA could potentially be beneficial to someone suffering from PTSD - there is research into this topic going on at the moment. However, stopping medication in order to take MDMA is a big step, that I wouldn't recommend.

You could maybe try contacting MAPS (www.maps.org) to discuss their research into MDMA, and see if there was any chance of getting her into a study (I would say that the chances are probably quite low, however).
 
While I agree that MDMA assisted therapy can be beneficial to those suffering from PTSD, I wouldn't suggest it in your friend's situation. Antidepressants have long half-lives (Cymbalta's is about 12 hours from what I have found and Abilify's is about 75 hours), so it may take weeks before they are cleared from her system. Also, Cymbalta seems to be one of those meds that has a particularly nasty discontinuation syndrome for many users.

Significant psychological problem + the meds + getting off the meds + MDMA + getting back on the meds...Doesn't sound like it would be good to me, but I'm not an expert and I don't know her. My opinion is she should think hard about the risk vs. reward and talk to an open minded and knowledgeable person (hopefully her psychiatrist fits this description) about it to decide.

Sim0n's suggestion about getting into a study is a good one. I hope it all works out well.
 
Can I just clarify - is it true to say that taking e is generally not going to do anything if I am on antidepressants? Or are there specific types that do not interfere with the roll. It seems every kind of antidepressant drug out there interferes with seratonin uptake!
 
Avanza or Remeron you can roll while taking that & it is an Anti Depressant
 
drancer said:
Can I just clarify - is it true to say that taking e is generally not going to do anything if I am on antidepressants? Or are there specific types that do not interfere with the roll. It seems every kind of antidepressant drug out there interferes with seratonin uptake!
Click to expand...


Some are actually life threatening when mixed.

What anti deps are u taking?
 
I started on Lovan about 3 days ago and then I stumbled upon this. I like to roll about every month or so, and my anxiety isn't so bad that I can't do without this prozac. I am going to stop as of tomorrow and get my doctor to prescribe me something else. Benzos maybe? That could work better, as it can also help me sleep which Lovan doesn't do. In fact, it keeps me up more often than not throughout the night, which is irritating.

I have also read about the addictive potential of benzos but if I take the correct dose, I believe that I should be OK. what do you think?
 
This is an answer that Veloxide once gave and I think it is well worth repeating.

Depression treatment requires that you take the antidepressant medication *uninterrupted* for a significant period (often six months or more). Stopping the medication to take pills will likely interfere with her treatment, both as a result of taking plls AND because she's stopped her medication.

If you want to try pills in the future, then that's your choice obviously. However you should not stop your treatment for depression for a night of (potential) fun, which could set you back months.


I would also advise that you check out the Directory and look up Prozac and mdma in post 2.
 
^^

I believe that some people can roll off of SNRI's, but I definitely wouldn't make the claim that everyone can roll even if they are taking an SNRI. I'm unsure as to why some people can while others can't, maybe someone with a more technical background can answer. :)
 
From Erowid

The clinical pharmacology of mirtazepine does state that it acts as a 5-HT2 and 5-HT3 antagonist. Some people believe that the serotonin 2A (5-HT2A) receptors are neccessary (but not sufficient) for the actions of many psychedelics such as psilocybin mushrooms (LSD and MDMA are not included in this group). It is quite likely that by blocking 5-HT2 receptors, you would prevent the ingested drug from being able to act on one of the main receptors necessary for its actions. Your conclusion is sound.

As for MDMA, the effects of this drug are mediated not by interaction with particular receptors, but more in the massive release of serotonin and dopamine that it triggers. So it is unlikely that mirtazapine would block its effects. However, it may still be possible that some of the beneficial effects of MDMA are modulated by 5-HT2 receptors, so you may be just left with primarily stimulatory side effects. Similarly, while LSD does not act on only 5-HT2 receptors, the blocking of these receptors might leave mostly side effects.
 
hey BL's, but was wonderin if instead of takin some E, if i was to pump a few SSRI's into me this would do any thing?

basically, even if its not worth replacing, but would taking aheap of Anti-depressants do anything. and dont worry, ill be safe

thanks aheap any, peace,
 
SSRI's are working for me. But then again.... I don't do drugs anymore (1.5 years) anyways.

And...I'm on a regimented dosage.

GrabHold
 
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No. SSRIs have absolutely no recreational value whether alone or in combination with another drug. Doing what you said could potentially put you at risk for Serotonin Syndrome.
 
Man I promise you will only ever do it once.

Just taking the proper dose of anti deps is bad enopugh withoput taking double or triple doses.

Its like taking a pill for a major body hangover.

Absolutely no recreational value at all.

They work completely differently to E.
 
DEAR GOD NOT THIS AGAIN!!

oh wait,the title is just the exact same as another one that got closed!

NE who......i used to be on em and NO its not the same as all!! SSRI's CONTROL your brain chemicals, X DUMPS your seritonin!!
 
Does the dose of an SSRI matter?

I'm tapering off of efexor at the moment, have been on 37.5mg for 2 weeks and just started moving down to half that. If I were to take x now would it have a better chance of working than when I was on a 150mg dose or is the dose irrelevent and all that matters is that there's still something doing it's job in your brain?

I seriously doubt I'd do it, but I'm curious as I haven't seen mention of it.
 
I think that you need to wait until your system is completely clear of the SSRI.

Now.....you are on effexor, which is an SNRI, slightly different than an SSRI. Some people say they are able to roll off even while using an SNRI, but others say they cannot.

I personally would wait until you are off of the antidepressant completely, it seems like you don't have that much time to go, so it's better to just wait. :)

Good luck to you.
 
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