SWIM has taken E on sunday and SWIM wishes to take it today but is worried about the depression during the comedown is their a way to avoid or lessen the comedown by any means?
The only way to "lessen" a comedown is to take a smaller dose, and a small dose will do jack shit if you took MDMA just 5 days ago. Dropping again so soon is never a good idea, you want to wait at least a few weeks, ideally a month or two between times. The comedown will be worse the more often you do it, and the experience wont be as good; so all around not really worth it.
depends on what you sniff and what you mean by "react with the mdma"
ime amphetamine is perfectly fine in the breaks between mdma doses.
some people report that meth increases their tolerance to mdma.
other entactogens like methylone or one of the apbs "count as" mdma and should be avoided.