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  • Trip Reports Moderator: Cheshire_Kat

MDMA (3 Pills) + Multiple Maois (150mg tablets) - Experienced - Psychedelic Love

Article from 2003 on 4 deaths in Finland attributed to this combo: http://www.erowid.org/references/texts/show/6045docid5675
Another one from 2010/2011 on another 4 deaths in Australia: http://www.sciencedirect.com/science/article/pii/S0379073811001757
Bluelight thread on the combo from 2002: http://www.bluelight.ru/vb/threads/...nd-MDMA-aka-quot-Perma-roll-quot?referrerid=0

(All shared purely for information and without comment; since I'm not a scientist)

I could share with you many articles in which MDMA or "pills" have caused death by themselves. There is always a risk in putting anything in to your body. Water is toxic at a certain amount, it increases the hydrostatic pressure in the capillaries which then causes passive diffusion of water into the brain cells until they lyse (burst).
 
I love when med students know everything.

Water makes cells lyse? Tell us more!

There really needs to be a masturbating smiley for these type of comments.
 
I love when any graduate-level student tries to veil poor logic with jargon.

And call it a bit totalitarian, but I really think that all of these crap posts trying to justify this combo should be deleted... regardless of their intended effect, I'm sure they will make people feel better about doing this combo.
 
I could share with you many articles in which MDMA or "pills" have caused death by themselves. There is always a risk in putting anything in to your body

Absolutely there is a risk. That's why harm reduction is about trying to know and manage those risks. If it was solely about hazard then we probably would be advocating total abstinence. In this case, the specific risk under discussion is the combination of e (however narrowly or broadly you want to define that) combined with a (specific) MAOI. The fact that pills alone have been linked to certain deaths does nothing to add to the debate as such

That said, some of your critics (those with better knowledge of pharmacology than me) should probably spend more time rebutting you arguments than taking cheap shots. Otherwise, how are the likes of me to further or understanding ;)
 
The harm reduction in question is how to use MDA/MDMA safely. Part of reducing harm is avoiding unsafe drug combinations.
Given how statistically rare the combination of MDA/MDMA and MAOIs is, and given how low the rate of fatality of MDMA taken alone is, the number of reported deaths for the combination is high.

ebola
 
Another thing that I didn't mention is because it is a reversible MAOI and competitive inhibitor, the higher the serotonin level goes, the lesser its effect, as serotonin and MAO both compete for binding to it and reach an equilibrium.

Have I seriously misinterpreted what you are trying to say or how the fuck does Moclobemide bind to serotonin?
 
That's not what he meant. Instead, under high concentrations of serotonin, competitive MAOA inhibitors might exert less of an effect, but this will prove relevant iff moclobemide's binding affinity to MAO is low enough to allow for displacement by high concentrations of 5ht (part of the logic here is that if there is relevantly strong inhibition of MAOA by moclobemide, we can assume high proportionate occupancy of MAO by the compound).

ebola
 
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