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MDAI's reuptake inhibition effects

Eyes On the Roll

Eyes On the Roll

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I heard about the 5-meo-dipt.
A couple days ago i came across some exciting news revolving around a different
research chemical. MDAI. This drug is like MDMA but with more of a sedating mellow
high. I know that MDAI releases serotonin, but it is said that MDAI also automatically
inhibits the re-uptake of serotonin when the high wears off. Does anyone know anything about
this? MDAI would deffinately be an interesting and effective anti depressant
 
I don't know about this but if it's any help...

I like MDAI a lot, take it too frequently actually at about twice a month. I get strong rushes and a good reaction to the (supposedly) high purity champagne coloured crystalline stuff I get taken orally at 125mg doses.

The thing that might relate to your question is that I have found my overall general mood is improved since I started doing it. Outlook much brighter, consistently.
 
MDAI is said to be non-neurotoxic, and since it is said to inhibit re-uptake of serotonin, I would wager a good guess that this substance can be abused day in and day out, like marijuana, with little damage to cognitive functions, and with the effect of an anti depressant.

taking MDAI twice a month isn't too frequently, so you should have nothing to worry about. I could deffinately see this substance being prescribed as an instant acting anti-depressant, to be taken daily
 
Eyes On the Roll said:
MDAI is said to be non-neurotoxic, and since it is said to inhibit re-uptake of serotonin, I would wager a good guess that this substance can be abused day in and day out, like marijuana, with little damage to cognitive functions, and with the effect of an anti depressant.

taking MDAI twice a month isn't too frequently, so you should have nothing to worry about. I could deffinately see this substance being prescribed as an instant acting anti-depressant, to be taken daily
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Ive taken 60mg MDAI 3 times a day for 2 weeks, on its own boring but with G a good mood booster, never noticed any comedown or aftereffects, but as it's a rc it can carry risks.
 
/\ that is true since it's a relatively new drug and little is known about risks/effects, but I think it would be awesome if researchers picked up MDAI and started testing it as an anti-deppressant cause of its ssri abilities, it makes the potential and possible medical future of MDAI interesting
 
I would wager a good guess that this substance can be abused day in and day out
Click to expand...

This is actually a terrible guess. Given how slow the endogenous synthesis of 5ht is, this should not prove sustainable. Also, people who have taken recreational doses multiple days in a row have reported diminishing effects and even brain zaps upon the last dose wearing off.

ebola
 
Eyes On the Roll said:
MDAI is said to be non-neurotoxic, and since it is said to inhibit re-uptake of serotonin, I would wager a good guess that this substance can be abused day in and day out, like marijuana, with little damage to cognitive functions, and with the effect of an anti depressant.

taking MDAI twice a month isn't too frequently, so you should have nothing to worry about. I could deffinately see this substance being prescribed as an instant acting anti-depressant, to be taken daily
Click to expand...

um, no

what about rapid downregulation of receptors?
 
ok well lets get back on topic and discuss MDAI's ability to inhibit the re-uptake of serotonin. Anyone know anything more about this effect? Or of an anti-deppressant effect?
 
Nearly all releasers are to some extent reuptake inhibitors. Links for studies showing how MDAI exerts reuptake inhibition outlasting 5ht efflux so as to preclude uptake of free radicals??
 
It does seem to me that there's a medical need for a class of medications that act as "acute antidepressants." Now, I would argue that those already exist in the form of mu-agonist opioids (and ketamine, and perhaps amphetamines), but there's a stigma and other complications attached to those substances, so a drug like MDAI might fit the bill.
 
Given the common comorbidity of depression and substance abuse disorders, most acute anti-depressants would prove dangerous to patients, lest they opt to use these agents for managing depression in the long term. One possible exception here is ketamine, as its anti-depressant effect isn't a direct result of the high.

ebola
 
ebola? said:
Given the common comorbidity of depression and substance abuse disorders, most acute anti-depressants would prove dangerous to patients, lest they opt to use these agents for managing depression in the long term. One possible exception here is ketamine, as its anti-depressant effect isn't a direct result of the high.

ebola
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Very true... which is what I was talking about in regards to opioids, etc. I was under the impression that MDAI was enjoyable but not particularly reinforcing? I could be way off on that though.

EDIT: Reading some of the MDAI threads it seems some people do find it "moreish" so yeah maybe I was off on that.
 
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Yeah...for those depressed, agents which lift depression relatively quickly but which also wear off quite rapidly become quite reinforcing, regardless of direct effects on VTA-centric dopaminergic transmission.

ebola
 
"Fast acting" antidepressants, used to include amphetamine and various re-uptake inhibitors (MPH, Pemoline).......they are no longer approved for this purpose for some very obvious reasons.

Taking a drug like this to treat major depression is a serious mistake. And without question, this drug has abuse potential, not aware of any self-admin studies, but those Bonobo's will self-administer lesser compounds........
 
Eyes On the Roll said:
MDAI is said to be non-neurotoxic, and since it is said to inhibit re-uptake of serotonin, I would wager a good guess that this substance can be abused day in and day out, like marijuana, with little damage to cognitive functions, and with the effect of an anti depressant.

taking MDAI twice a month isn't too frequently, so you should have nothing to worry about. I could deffinately see this substance being prescribed as an instant acting anti-depressant, to be taken daily
Click to expand...

I am very careful with most RCs, sometimes leaving months in between experiences so for me, doing this 2x a month is too frequently. I am not certain why I am treating MDAI differently, unlike a lot of reporters it has quite a strong effect on me so I certainly don't see it as a weak substance, not in the slightest.

Taking as read a new substance that is pretty much untested on humans is "non-neurotoxic" and shovelling it down on a daily basis is a little too reckless for me. I tend to find myself concerned for the future, I love drugs across the board but just as I have managed to have a love affair with opiates/opioids for the last twenty years and never tasted withdrawal I don't want to find that later on in life I am a drooling braindead mess because of RC use. So I try to err on the side of caution.

The thing that's bothering me about MDAI is that I still have two 6-APB pellets from the first pressing, aMT, MXE and god knows what else kicking around 'for a rainy day' but I keep going for the MDAI and keep topping up my stocks. It's been 2 weeks since I last did it and I'm looking forward to doing it tonight, I've been looking forward to it for a week or so - this is an addictive behaviour pattern that I've only ever exhibited before with alcohol.

Not a panic, I'm just wondering why I have taken to MDAI the way I have. Unfortunately try as I might, the info isn't readily available to enable me to answer my question..
 
How long does the reuptake effects of MDAI last? Its been 5 days since my last dose of MDAI and I still have an annoying prozac-like effect from this drug...what can I do to get rid of this feeling?
 
~NaStYNaI~ said:
What do you mean by "on its own boring but with G a good mood booster".?
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Most find that MDAI on its own is quite boring as it doesn't have the magic that MDXX drugs or even methylone do - the poster was talking about mixing it with GHB.

I personally find that a 1:1 MDAI:methylone combo pretty much replicates MDMA to the letter but lasts for an hour or two longer than MDMA itself does. Very nice drug.
 
I find that mdai and mpa produce an experience close to molly but without the magic. I haven't noticed any subjective ssri effects but it wouldn't surprise me to learn that they are there.
 
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