aced126
Bluelighter
- Joined
- May 18, 2015
- Messages
- 1,047
Before I start, a short introduction. I am quite experienced with serotonergics like MDAI, and I also like to deeply study the science behind these compounds. This was however my first time taking this particular analogue of MDMA, called MDAI. It is quite a similar molecule to MDMA, but it has a rather different pharmacodynamic profile. It is much more selective for serotonin release than dopamine release (unlike dual releasers like MDMA, bK-MDMA and 4-methyl-methcathinone), and Nichols found it to be non-neurotoxic.
From roughly 200 to 250mg of MDAI (I know it's not ideal to use your eye and it is better harm reduction to use a scale, but for MDAI with its relatively large dosage, the risks eyeballing a dose are minimal; for lower dose compounds always use a scale), I separated 2 doses in proportions of roughly 0.6 and 0.4. I took the first smaller dose, knowing that I probably will not even reach threshold effects but I wanted to make sure I did not have an adverse reaction to it. An hour later after only minor stimulation was observed, I ingested the second and final dose.
An hour after this, I was coming up and it felt pretty nice. I was very empathic, and I was able to address loads of things in my mind which would've been harder to do normally. Then as I transitioned into the peak I listened to music which felt very nice as well. Overall, the peak was very enjoyable. It obviously wasn't of an intensity one would achieve from MDMA, but it was still very enjoyable nevertheless.
The peak maybe lasted an hour to an hour and a half, quite short in my opinion. However when I started to realise I was on the road back down, I was skeptical if I would have a harsh comedown (this sometimes happens with methylone, I'll be feeling extremely empathic one moment, then the next moment all the empathy evaporates so quickly and I'm left wondering why the hell I'm talking to whoever I'm talking to, that is probably the worst part of it). To my complete surprise, when I was fully down roughly 4 to 5 hours after the time of first ingestion, I felt absolutely amazing. The feeling is hard to describe. It was due to my realisation that this compound had made a very very very little hole in me, unlike other hard serotonergics. It was extremely antidepressant like in action, and I felt very content with life. I could not believe that I was feeling this way, so physically and mentally undrained but instead so full of life (something which is simply plain unusual with other serotonergics I use).
This made me think that maybe selective SRAs could be used to treat depression. Currently mainly SSRIs are used, and their mechanism of action is not by directly increasing synaptic serotonin concentrations by blocking the serotonin transporter. Rather it is a result of autoreceptor downregulation which in turn leads to more exocytosis of serotonin vesicles. Maybe an extremely weak SRA could be used in a fashion to what I describe to produce similar but fast acting results (SSRIs have to be used continually and for about 2 weeks for it to start working properly). And if so, it could even be used on a pro re nata basis, like how alprazolam is used in this fashion to fight acute panic attacks.
I might give this an update tomorrow on how my mood is doing then. But for now, in conclusion, I am actually tending to say that I like this more than MDMA, because it is still extremely enjoyable but it doesn't have the risk of suffering hindering after-effects later due to significant depletion of dopamine and serotonin.
From roughly 200 to 250mg of MDAI (I know it's not ideal to use your eye and it is better harm reduction to use a scale, but for MDAI with its relatively large dosage, the risks eyeballing a dose are minimal; for lower dose compounds always use a scale), I separated 2 doses in proportions of roughly 0.6 and 0.4. I took the first smaller dose, knowing that I probably will not even reach threshold effects but I wanted to make sure I did not have an adverse reaction to it. An hour later after only minor stimulation was observed, I ingested the second and final dose.
An hour after this, I was coming up and it felt pretty nice. I was very empathic, and I was able to address loads of things in my mind which would've been harder to do normally. Then as I transitioned into the peak I listened to music which felt very nice as well. Overall, the peak was very enjoyable. It obviously wasn't of an intensity one would achieve from MDMA, but it was still very enjoyable nevertheless.
The peak maybe lasted an hour to an hour and a half, quite short in my opinion. However when I started to realise I was on the road back down, I was skeptical if I would have a harsh comedown (this sometimes happens with methylone, I'll be feeling extremely empathic one moment, then the next moment all the empathy evaporates so quickly and I'm left wondering why the hell I'm talking to whoever I'm talking to, that is probably the worst part of it). To my complete surprise, when I was fully down roughly 4 to 5 hours after the time of first ingestion, I felt absolutely amazing. The feeling is hard to describe. It was due to my realisation that this compound had made a very very very little hole in me, unlike other hard serotonergics. It was extremely antidepressant like in action, and I felt very content with life. I could not believe that I was feeling this way, so physically and mentally undrained but instead so full of life (something which is simply plain unusual with other serotonergics I use).
This made me think that maybe selective SRAs could be used to treat depression. Currently mainly SSRIs are used, and their mechanism of action is not by directly increasing synaptic serotonin concentrations by blocking the serotonin transporter. Rather it is a result of autoreceptor downregulation which in turn leads to more exocytosis of serotonin vesicles. Maybe an extremely weak SRA could be used in a fashion to what I describe to produce similar but fast acting results (SSRIs have to be used continually and for about 2 weeks for it to start working properly). And if so, it could even be used on a pro re nata basis, like how alprazolam is used in this fashion to fight acute panic attacks.
I might give this an update tomorrow on how my mood is doing then. But for now, in conclusion, I am actually tending to say that I like this more than MDMA, because it is still extremely enjoyable but it doesn't have the risk of suffering hindering after-effects later due to significant depletion of dopamine and serotonin.
