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MDA vs MDMA - why does MDA keep working when MDMA doesn't?

Now you're fucking talking. I like that idea. Though I wonder... I wonder because the 3,4-phenethylamines wern't that active... now, 3,4-HHA, thats alpha-methyldopamine right? I can't find any behavioural information on direct application of HHA to the brain (ICV or otherwise), only those fucking glutathione conjugates! One guy give it SC, and Ricuarte goes in and gives it ICV but doesn't say anything about behaviour... but yet seeing as neither the 3,4-MeO-amphetamine nor the 3,4-MeO-PEA are active to much extent in humans, I'm not holding out much hope, still, great idea.

Do I have any other ideas? Only one that is so far out its stupid, but I'll still put it down on paper, just because it is creative. MDA could traffic to PLD very highly, which could remodel the cell so that subsequent 5-HT traffics more to which ever 2nd messanger is responsible for hallucinations (PLA2?), hence causing the serotonin released by its amphetamine like action to be hallucinatory..

Possible, MDA could somehow be more specific to areas of the brain which are to do with arachidonic acid... shit, I don't know... which I start thinking about hallucinogens, I just start thinking about the millions of experiments that -the man- should let me do.
 
Now you're fucking talking. I like that idea. Though I wonder... I wonder because the 3,4-phenethylamines wern't that active... now, 3,4-HHA, thats alpha-methyldopamine right?
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3,4,HHA is a-MeDA, yes.

I can't find any behavioural information on direct application of HHA to the brain (ICV or otherwise), only those fucking glutathione conjugates! One guy give it SC, and Ricuarte goes in and gives it ICV but doesn't say anything about behaviour... but yet seeing as neither the 3,4-MeO-amphetamine nor the 3,4-MeO-PEA are active to much extent in humans, I'm not holding out much hope, still, great idea.
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Yeah but those have a bulky methoxy group where a simple HO would be. It's no wonder they're not very active, if at all. I like: http://www.maps.org/research/mdma/litupdates/non-human/toxicity/11.02/carvalho2002.html , where a comment was made (re: Arch Toxicol 76: 581-588 ) "...The authors seem to be unaware of the fact that HMMA and HMA, and not MDA, are major metabolites in humans, as they failed to study the effects of either of these compounds."

I submit that this is no accident. I'm pretty sure Ricaurte and Co all know that 3,4,HHA is the deal, but how are you going to get funding from that?

MDMA not really neurotoxic -- Scientists discover 'toxic metabolite'

(AP) Scientists at Johns Hopkins today signed the death certificates for their careers when they announced that a metabolite of MDMA, and not MDMA itself is neurotoxic.
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Do I have any other ideas? Only one that is so far out its stupid, but I'll still put it down on paper, just because it is creative. MDA could traffic to PLD very highly, which could remodel the cell so that subsequent 5-HT traffics more to which ever 2nd messanger is responsible for hallucinations (PLA2?), hence causing the serotonin released by its amphetamine like action to be hallucinatory..
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How's this for far out: High levels of OH-amphetamines (or a-Me-DA analogues) attaching to 5HT2 receptors are responsible for the amphetamine model of psychosis.

Possible, MDA could somehow be more specific to areas of the brain which are to do with arachidonic acid... shit, I don't know... which I start thinking about hallucinogens, I just start thinking about the millions of experiments that -the man- should let me do.
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I like 5HT2 activation by 3,4,OH-amp compounds. It just makes sense to me. 3,4,OH compounds can be formed from amp in vivo. How's that for a model of amphetamine psychosis? Levels of these metabolites get high enough and psychosis results. I'd like to see the correlation between amp psychosis and CYP2D deficient persons, 2D6 is necessary for p-hydroxylation of the amps. Shulgin once wondered about pma and schizophrenia, but what about pha?

That OH would have a much easier time getting around than a MeO...


X
 
Well go forward this shit to Shulgin, and get him and Nichols to do as a little radioligand experiment. Wouldn't even take the lazy bastards the afternoon! lol.
 
Well go forward this shit to Shulgin, and get him and Nichols to do as a little radioligand experiment. Wouldn't even take the lazy bastards the afternoon! lol.
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I have a feeling they already know this. I think political concerns are preventing research in this area.


X
 
Ahhhh, not a chance. What would be poltical concern if in Nichols next paper he put alpha-Me-Da as compound 7. or some shit?
 
What? No, the can have the name, just, I don't see why anyone would care if he showed that a-me-Da bound to 5-HT2A.
 
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