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MDA vs MDMA - why does MDA keep working when MDMA doesn't?

C

Calvin HtownsFinest

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I still don't get this!

Why even though MDA rolls are much more intence, can the sessions last longer than MDMA? After about 12 hrs on MDMA any more and I just get cracked out whereas on MDA it seems like it never has to end!

Does MDA effect serotonin any differently then MDMA?

Can someone explain this?
 
AznHangukBoi said:
... callum got caught again..? x.x; that sucks...
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I feel obliged to point out that registering multiple user accounts is against the bluelight user agreement.

To answer the question, MDA does appear to have a mode of action independent of MDMA, though they both involve serotonin release. No-one is entirely sure as to the origin of MDA's more psychedelic activity and also why it appears to work when MDMA fails. Bilz0r would know more than I...

Editing the topic for clarity...
 
haha yes, remmeber the 12 hour rolls on MDA, sigh no more in my area. i too do not understand why, if u have a really really long MDMA roll from a couple tabs i would be confident to say you get meth in the tabs then
 
VelocideX said:
I feel obliged to point out that registering multiple user accounts is against the bluelight user agreement.

To answer the question, MDA does appear to have a mode of action independent of MDMA, though they both involve serotonin release. No-one is entirely sure as to the origin of MDA's more psychedelic activity and also why it appears to work when MDMA fails. Bilz0r would know more than I...

Editing the topic for clarity...
Click to expand...

Is it a multiple user acount if the last acount no longer exists?
 
lll Callum lll said:
Is it a multiple user acount if the last acount no longer exists?
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good point.... beloq quoted from the useragreement

register multiple accounts ("alias accounts");
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wouldnt the ' ("alias accounts") ' make it mean that refers to the restriction of use of multiple accounts strictly for "aka" reasons?


...way off topic i know.. back ontopic though... i dont know how it works, but i know MDA seems to last a lot longer for me as well than mdma, and more speedier, and less tolerance imo..
 
It seems to me that registering user accounts specifically for the purpose of defeating a ban is contrary to the purpose of the ban. If you have an issue, take it up with the board administrators, not myself. Anyway, back to the topic at hand..
 
If you are banned, you can register another account. If its an obvious re-register, as in the case of ||Callum||, then you'll be watched carefully and need to behave well. If its a completely different name and people don't know its you, you have the same chances as everyone else. If you play nice, you stay, if you don't, go get banned. It takes a lot less effort to ban you than it does to reregister so trolls quickly get tired of it.
 
Okay, this is preety hypothetical, but basically, I'm going to say that I think that MDA has a longer half life that MDMA. As far as I'm awear, there is no (accurate) measurement of the halflife of MDA in humans, but, I am under the impression that the rate of MDA ---> inactive metabolite is slower than then rate of MDMA ---> inactive metabolite. I know that MDMA is turned into MDA, but this creates only a small peak MDA concentration (%5 of MDMA).
 
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True, but it never purports to be well controlled nor empirical in any true sense of the word.

If nothing else it highlights the view that many people seem to anecdotally suggest MDA has a much longer method of action that MDMA, and that you can keep redosing MDA to some effect whereas you cannot with MDMA.
 
MDA is a partial 5HT2a agonist, this is why redosing "seems" to work with MDA but not MDMA. MDMA has little to no affinity for post-synaptic receptors.


X
 
i find that redosing MDA makes it alot more physically and psychadelically intense. ie. the physical rush and hallucinations get stronger with the redose. however the feeling of fuckedness gets stronger too, so i havent been game to try a 3rd wave yet :)
 
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This is what I thought, too, but bilz0r referred me to several pages that show MDA and MDMA's affinity for 5-HT2 to be about the same?
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I don't see how that's really possible, since MDA is hallucinogenic and MDMA (except in very large dosages where the levels of MDA could be expected to be higher) is not.


X
 
Yeah, affinity about the same, but MDA is far more efficacious. At least when it comes to IP3 production.

But it doesn't matter cause the affinity is so small incomparison to SERT that I doubt there is much going on there... well maybe, Well when rats are given NEUROTOXIC doses of MDMA, big doses around the 10mg/kg range, they get brain concentrations of MDMA around 10µM. Recreationally, we get more like 1mg/kg so we could geuss our brain concentration is more like 1µM, (probably less, maybe half, because we're talking oral vs IP) which is right around dopamine/serotonin release EC50s, but about 10 times lower than the 5-HT2A Kd, so you've be getting like 5% binding or something.

I'm just gonna make a table here for my own ammusement

Species..............Dose.........[Plasma]....[Brain]

Normal Human...1mg/kg.....1µM...........(1µM)
Overdose...........unknown..1.6µM........3.6µM
Rat.....................10mg/kg...6.2µM........5µM

hmm... those concentrations aren't at the same time, for the human and the rat, the plasma is peak, and the rat brain is peak as well, which happens at about 1 hour, vs 20minutes for plasma. The overdose is just when the found him, probably around T+12, poor fucker. Probably had some metabolism of plasma MDMA.



STILL- Why is MDA more hallucinogenic? I don't have a fucking clue, but it certainly isn't because of innate agonism at 5-HT2A

Those numbers came from-
Normal human: De La Torre et al., (2000) Ann N Y Acad Sci. 914:225-37
Overdose: De Letter et al., (2004) Forensic Sci Int. 141(2-3):85-90
Rat plasma: Colado et al., (1995) Brit J Pharmacol 115:1281-1289
Rat Brain: Esteban et al., (2001)Psychopharmacol 154:251–260
 
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How about agonism of 5HT2a by MDA metabolites? Plasma concentrations of 34HHA is expected to be greater with MDA than MDMA.


X
 
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