maybe im wrong

[nativenick]

but ive noticed that sedative drugs alcohol, opiates, benzodiazepines are the worst offenders for physical addiction and withdrawls once your heavy into them. we all no opiate addiction is no walk in the park benzo withdrawls are just plain rotten and ive even heard that alcoholism can give addiction to opiates a run for its money. not to mention withdrawls from benzos and opiates can sometimes be fatal (i dont even think meth can do that if its physically addicting).

more often than not or even the majority of the time sedatives/narcotics are physically addicting. wheras stimulants like cocaine and amphetamines have little if any potential for physical addiction (again there may be a few exceptions). why is this? what is it about downer drugs that have the potential to make you physically dependant and dish out deadly withdrawls? what is the pharmacology behind this? are there recreational drugs that arent downers that have potential for physical addiction?

im just curious is all

 

[BilZ0r]

Well the answer why benzos/barbitruates have strong physical withdrawal symptomes while stimulants don't, is because, although you classify them as opposties (uppers vs downers), the actual systems they work on are in no way opposites.

Benzos, barbs, alcohol work on GABAA receptors, I believe that every single neuron in the brain has GABAA receptors. They are incredible important in the microsecond to microsecond control of neuronal activity. They brain could function to a degree with just GABA and glutamate, the other neurotransmitters are larger ancillary.

And those other neurotransmitters (noradrenaline, dopamine serotonin) are what the uppers hits. THey're just not as important in keeping your brain going.

Don't ask me why opioids are quite so bad, I mean, they've got a somewhat important role in gastric molitiy (hence why the GI stuff with opioid withdrawals are a bit of a bitch).

 

[bigdaddy123]

Believe it or not,alchohol wd's you can die from,all other wd's [opiate,etc.] you can't die from,but you feel like your going to,or wish that you would!