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Maybe 5HTP isn't the best idea?

Idk if its just me but reading all this stuff about mdma induced depression totally turns me off to the idea of rolling. Prior to a month ago I hadn't rolled in almost 3 years from being on ssris, but I decided to ween myself off unconsciously and by skipping a dose now and then in increasing frequency I managed to come off it with really only about 1 month of depression. after over a month off the lexy I injected 75mg MDA I.V. lets just say holding on to the toilet for dear life while the vomit twists and distorts into what could be best described as a earth toned kaleidoscope, while sweating liters in a matter of minutes, just doesn't cut it.

But if you put a couple bombs in front of me right now I'd be hard pressed to take them, I really don't feel like being depressed, especially with my history of depression.
 
Genetic Freak said:
Supplementation of B-6 with 5-HTP isn't recommended..... 5-htp is a direct precursor to serotonin and passes the BBB with ease acting as a pure legal SSRI essentially. However if you supplement with B6 at the same time it converts the 5-htp into 5-ht within the blood stream before reaching the brain. The problem is 5-ht itself cannot pass into the BBB smoothly like its precursor which inevitably results in free serotonin radicals circulating the blood stream causing hypertension, tarchardia and other serotonin toxicity symptoms.
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The 5-HTP I bought contained vitamin B6 in facted I couldn't find any that didn't have vitamin B6 as well. Have I literally just pissed my money away?
 
Okami said:
The 5-HTP I bought contained vitamin B6 in facted I couldn't find any that didn't have vitamin B6 as well. Have I literally just pissed my money away?
Click to expand...

A Moderator on another forum I use has done extensive research on 5-HTP.... I have quoted his findings.. I'll see if he will post some references....
 
i usually take 5-htp a couple days after my roll
was curious on any problems with taking it to finish off the night?

much appreciated
 
Simple. B-6 in any oral form (pyridoxine HCL, pyridoxamine, P5P) taken at the same time as or within 2-3 hours before (depending on dosage and form) will enhance peripheral conversion to Serotonin. Peripheral Serotonin does not cross the Blood-Brain Barrier and will act on intestinal smooth muscle. This means nausea, diarrhea, possible spasms and increases in hepatic MAO-A. Leave it alone. Use 5-HTP without B-6 and more will cross the BBB and be converted in the CNS to Serotonin, Melatonin, and (if enough methyl donors are around) DMT. Long term use of 5HTP will result in increased MAO-A in the CNS and decreased tryptophan hydroxylase to compensate. Re-uptake transporters can also increase. In Short, 5HTP alone boosts CNS Serotonin rapidly. Take your vitamins later. You don't need as much B-6 as you think and P5P orally is a waste of money. Try it out and see what I mean. Less nausea and a lower dosage is a good thing. Tryptophan can be much more practical and is virtually unaffected by B-6 supplements. 5HTP is to Serotonin as L-DOPA is to Dopamine. B-6=bad side effects. Dosage? Well, Don't over do it with 5HTP, especially on SSRI's. Hours of Vomiting and hyperthermia.

http://www.bluelight.ru/vb/threads/4...-b6-with-5-htp
http://www.bluelight.ru/vb/threads/2...p-b6-ssri-meth
http://www.bluelight.ru/vb/threads/2...angerous-combo
http://yarchive.net/med/5-htp.html
 
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