Misc Maximize snorting efficiency: Tips, Tricks, & Teks

[Treon s verdery]

DMSO causes many drugs to be more absorbable and might or might not have been described as being harmless to peptides at 1-3% of a water solution. Dmso is on ebay. I'm just imagining its possible but putting any snortable drug into a container with a big fresh silica gel packet to absorb all the moisture, then putting the drug into a different container with some toilet paper moistened with 100% dmso would cause the powder to absorb several % dmso while still remaining a powder, a powder that is 2-6% dmso might get really rapid absorption and produce a bigger rush and faster action.

Liposomes might actually already be published for nasal peptide delivery. Liposomes are like eentsy bags made out of fat and a water attractant, like phosphatidylcholine or phosphatidylserine. There are instructions online but basically you put vitamin store phospholipid and your drug in an ultrasonic jewelry cleaner for 20 minutes. Liposomes increase bioavailability more than 10 times, so, just imagine if MDMA were ten times cheaper a dose.

A thought i had for snorting-like buccal (cheek), rolled on the tongue, or vaginal delivery is making a very slightly gooey peptide syrup, then using one of the iontophoretic beauty serum transporting wands they have on aliexpress for $3-25. Iontophoresis can transport chemicals to a depth of 1.5cm per 20 minutes.

Iontophoresis is is not so easy at the nose, but ultrasound is, and might jiggle particles and powders to dissolve. I think if you look up beauty ultrasound face at aliexpress you will find $4-16 ultrasound massagers for the face that if pressed into the base of the nose could cause greater velocity of snorted drug dissolving

 

[Cuncefuct]

Please do not take offense to my reply "spaceyourbass", but I think why nobody else does what you do with suboxone or subutex etc... Is because it is pointless--it has no effects, of any type that are greater than the effects felt from sublingual admin. By putting a chunk of pill in your nose you would avoid the main purpose of snorting a drug---> which is that you powderize the drug creating a larger surface area allowing large amounts of the drug to rapidly be absorbed by nasal membranes giving a stronger high.
Having the pill dissolve in your nose or under your tongue would yield the exact same effects at the least and putting the pill under the tongue is (I imagine) far more comfortable than pushing a pill up ones nostril

People absolutely do this. I've even seen other prisoners IV this stuff and it still work for the majority of people. Also he's talking about the suboxone film not a pill, not saying its better than snorting a pill because idk the pros and cons in full. But there are some differences worth exploring. What he said makes sense to me. And the whole argument over will the narcan hit me first is irrelevant. Bupe has a higher binding affinity to the opioid receptors than narcan. Even if the naloxone hits your brain first bupe will win that battle in the long run because it has a MUCH longer half-life compared to naloxone. I've also tried snorting bupe film and it did work in the fact that it didn't cause immediate withdrawal.

 

[DeathIndustrial88]

People absolutely do this. I've even seen other prisoners IV this stuff and it still work for the majority of people. Also he's talking about the suboxone film not a pill, not saying its better than snorting a pill because idk the pros and cons in full. But there are some differences worth exploring. What he said makes sense to me. And the whole argument over will the narcan hit me first is irrelevant. Bupe has a higher binding affinity to the opioid receptors than narcan. Even if the naloxone hits your brain first bupe will win that battle in the long run because it has a MUCH longer half-life compared to naloxone. I've also tried snorting bupe film and it did work in the fact that it didn't cause immediate withdrawal.

Totally agree.

I have 10 years experience with IN bupe & it is absolutely different than the sublingual route.
If you have no tolerance or whatever, then yeah you can probably feel just fine with the sublingual route because bupe is so potent.
But IN hits a lot faster & reaches the brain quicker. The quickness of how fast a drug hits the brain can also up the chances of feeling euphoria, even if it's just mild with a drug like bupe. Sublingual bupe actually has a horrible BA (bioavailability). From what I remember reading, studies showed that you only absorb about 30% of the dose you take under the tongue. And the studies were also done with bupe in an alcohol solution to help absorption. So the BA is probably even a little lower if you're not putting alcohol under your tongue along with it. So IN use means being able to use less bupe at a time, while achieving faster onset of effects & a better chance at a little "well-being" or mild euphoria.

That comment you're replying to is pretty old, so I dunno if the person is still here, but I bet they already had a big tolerance before trying bupe. Cause everything they said only applies to some one with a tolerance to either bupe or full agonists. Otherwise, non-tolerant people & people with low tolerances can absolutely get effects from it. Hell when I first started bupe, I was using it to "get high" when I didn't have heroin or other opioids. I've also seen other people nod out hard & puke from literal crumbs of buprenorphine, so it absolutely "has effects", contrary to what that user said.