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masturbation- Nicotine analogue

Plus, it would probably vaporize fine as a salt, no? Insufflation might also be an option.... Maybe not. But the smoking route is still open.
 
Actually, Meth HCl is the common smoked form according to this thread:

Pure methamphetamine is easily crystallised and is more readily smokeable than amphetamine because it doesn't have to be converted to freebase first (since methamphetamine sublimes directly from solid to vapour form with the application of heat).
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For this reason the sulphate salt is preferable to the hydrochloride salt; as a consequence, most 'street speed' is amphetamine sulphate. In the case of methamphetamine, the HCl salt is far more common, because it forms better crystals and the sulphate is not suitable for smoking.
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Plus, it would probably vaporize fine as a salt, no? Insufflation might also be an option.... Maybe not. But the smoking route is still open.

Thats really difficult to predict.. It may not.
 
Who wants to get cracking on it? Do you think synth from nicotine is an option?
 
I dont know any direct (one step) routes to throw that methyl on there, you could possibly do it in a roundabout way though.
 
It is also a matter of putting the chlorine on the benzyl ring.... Ouch.
 
otb01 said:
Why not smoke it as a salt? That's how nicotine is traditionally consumed if you think about it. How about spreading it through a smokable material in an emptied out cigarette?

Here's how nicotine (primarily) metabolizes:
220px-Nicotine-2D-skeletal.png


200px-Cotinine.png


The oxygen gets double bound at the site where I have put the chlorine, hopefully making its metabolism a lot harder.
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What you have is more of an analogue of Epibatidine than nicotine. I'd look at how it's metabolised instead, especially considering where the chloro is located.

I don't think you really want anything that slows metabolism. All of these drugs are going to be exceptionally toxic, though. Nicotine's toxicity isn't borne out from some peripheral effect, but it's central activity.

Hence why I was more interested in the more likely to be recreational DARI analogue.
 
Hm. Agreed. But I would like to keep the substitution on the pyrro because it might prevent some metabolism. Wouldn't my analogue still be a DARI? The metabolism of epibatidine is on the azabicycle, which my analogue does not have.

Btw, I might be foolish in suggesting this but dropping the nitrogen in the benzyl group (and the chlorine I added) and adding a methylenedioxy ring could be promising, no? Or possibly the bonding on the nitrogen would fuck it up.
 
It is also a matter of putting the chlorine on the benzyl ring.... Ouch.

Free-radical chlorination would be optimal.. I dont know if it would cause troubles with the rest of the molecule but it seems like it would be easier than going through the effort of protecting/deprotecting the nitrogen for friedel-crafts type conditions


At a second glance, it seems as though the conditions for the ortho substitution are pretty vigorous (500 degs)
 
But what are the possible byproducts? We don't want some kind of MPTP thing happening......
 
I dont know, theres all sorts of shit that could happen at those temperatures.. The alkyl ring may break, or you may get the chlorine substituted at different positions (also, why did you pick the ortho?)

Someone else may know how to chlorinate the ortho position more efficiently but it looks like to do it right you'd have to start from scratch somehow.


Didnt that MPTP thing only happen because of street chemists? If you're planning to carry out a synthesis at home you should either find a well documented synthesis in the literature with known and reliable methods for purification (good enough for ingestion) or have some access to analytical equipment.
 
heh, or that.

I dont know much about pharmacology and SAR of many classes of compounds (Ive only just started learning) so I couldnt tell you if its worth it or not.
 
Well I'd probably do it if the synth is cheap but I'd be WAY too worried about toxicity.
 
otb01 said:
Hm. Agreed. But I would like to keep the substitution on the pyrro because it might prevent some metabolism. Wouldn't my analogue still be a DARI? The metabolism of epibatidine is on the azabicycle, which my analogue does not have.

Btw, I might be foolish in suggesting this but dropping the nitrogen in the benzyl group (and the chlorine I added) and adding a methylenedioxy ring could be promising, no? Or possibly the bonding on the nitrogen would fuck it up.
Click to expand...

Because it's features favor the SARs of nicotinics than DARIs? You don't see pyrrolidine rings in DARIs much (none to my knowledge).
 
Ham-milton said:
Hence why I was more interested in the more likely to be recreational DARI analogue.
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Where are you getting the information that the original analogue (At start of thread without pyridine) has ANY sort of DARI activity?

It's not like it has a PEA skeleton??


and discussion of smoking the salts of super potent nicotine analogue sounds stupid if not lethal.
 
and discussion of smoking the salts of super potent nicotine analogue sounds stupid if not lethal.

I really wouldnt enjoy nicotine if it lasted any longer than it did either
 
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