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Marquis result question

I was thinking, so the amount needed for a result is in the micrograms right? So what if you have a DO-x compound inside some binder say like 5mg-50mg, 1:10. If we estimate that a pinhead size scraping is around 1mg <which it may or may not be> then there would only be 100mg in there of active compound to react. would this be sufficient?
 
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