🧑‍🌾 Gardening 🧑‍🌾 Mapacho/Makhorka: My Nicotine back-to-the-roots Project almost 5 months later.

[TheLightBringer]

12 days later, 15 effin october in Dutch climate, the Makhorkas are growing huge. I dont think i'll get seeds this year but look at these!

this one shows its first flower bud.. Not gonna make it i think before the frost, but a good leaf harvest is coming!

The leaves shine with nicotine. I love this plant, and old CCCP Makhorka, as grown in Siberia, proves to be fairly hardy so far. Please: mild weather!

Your plants are looking really beautiful. I just got done with fermenting a batch and currently drying another, thinking of making rapé for the first time

 

[red22]

Quote ↓


In a world choking on smoke and noise, we remember another way.

A circle of protection, a web of women, and the medicine of Mapacho anchoring us to Earth and stars.

This is the work of repair,
the weaving back of what was torn.

Read the full piece on my Substack! [https://casacurativa.substack.com/p/mapacho-vs-manosphere]
And if it moves you, hit subscribe so you never miss a thread in this larger weave. We be weavin these plants into the social fabric daily!

‌https://www.instagram.com/casacurativa/p/DQNyyeNjdDm/ 2025-10-25

 

[red22]

The Spirit of Tobacco: Bridging Science, Mindful Use & Ceremony
Join us Monday, November 10th at 5 PM PST / 8 PM EST for a live interview + Q&A with Annelene Sillet, sacred medicine educator and physiotherapist bridging ancestral wisdom with modern science.
Together, we’ll explore how Tobacco—often misunderstood in the West—can be reclaimed as a revered teacher plant: one that, when used with intention, supports grounding, mood, protection, and prayer.
Learn how traditional wisdom and modern research intersect

Understand Tobacco’s spiritual and physiological roles

Explore mindful relationship and responsible use
This live session is exclusively for MFK Community members, accessible through our private platform.

Try it free or join the circle at kambocommunity.com
About Annelene Sillet:

Venezuelan-born and Canada-based, Anne bridges therapeutic science with Indigenous traditions through Jungle Cultura, Cannabis Education Canada, and Natural Budz. Their work in sacred medicine education has been recognized by the United Nations Alternative Medicine Commission, Boom Festival, and Native Child & Family Services of Toronto.

h‌ttps://www.instagram.com/medicinefrogkambo/p/DQwl0DgDe-0/ 2025-11-07

 

[red22]

"from what I have seen across indigenous traditions, tobacco is regarded with the same reverence as Ayahuasca and is smoked in ceremony and out of ceremony too. I’m genuinely curious where she learned that mapacho smoke should only be used as incense" Annelene José Sillet Yépez, 2025-11-07, h‍ttps://www.instagram.com/medicinefrogkambo/p/DQwl0DgDe-0/comments/

 

[red22]

Quote:

Sacred Master Plant Mapacho or Tobacco is regarded as the most powerful master plant of all - able to move across nine dimensions. Used for cleansing, healing and blessing - it has a profound acuity in its ability to extract pain or energy.

Catriona Wallace. 2025-11-22. h‍ttps://www.instagram.com/ayahealingretreats/p/DRXa4kojswk/comments/

 

[red22]

Anxiolytic Effect of Two Tobacco Essential Oils

 

[red22]

Nicotine derivatives

 

[Asante]

The Mapacho is sitting dried and crumbled in my freezer in good quantity, I just havent gotten around to engaging the Spirit seriously yet.
Its almost indoor plantng time again, and definitely i'll grow a bigger crop of Mapacho this year yet, even though I haven't sought out the Entheogen Mapacho, just the utility of nicotine lozenges.

I want to make the Shamanic Use of Mapacho distinct from nicotine use, and make it spirit work only, not as an indulgence, which nicotine lozenges are.

The green dried Mapacho smells heavenly.

Red22 thank you for keeping the topic alive with your quality contributions.

 

[red22]

Vaping tobacco: 12 things you should know about vaping tobacco

 

[red22]

Understanding Tobacco Absolute: Is It Safe and Nicotine-Free?

Claude says that article's claim that their product is nicotine-free doesn't make sense.

 

[red22]

Tobacco And Nicotine: History, Facts and Production

"From this article, you will learn what are nicotine’s origins, what danger may result from contact with it, and how it is obtained."

 

[red22]

Anxiolytic Effect of Two Tobacco Essential Oils

Background & Objective

Tobacco leaf has traditionally been used in folk medicine to treat anxiety and depression, and tobacco essential oils are known to have antioxidant, anti-inflammatory, and neuroprotective properties. However, no prior research had examined their anti-anxiety (anxiolytic) effects. This study was the first to investigate whether tobacco essential oils could reduce anxiety in mice.

What Was Tested

Two essential oils were studied — one from Yunnan tobacco (YTO) and one from Zimbabwe tobacco (ZTO) — at three concentrations (0.1%, 1%, 10%), administered via both inhalation and transdermal (skin) application.

Chemical Composition

GC/MS analysis identified 22 compounds in YTO and 35 in ZTO. The dominant compound in both was neophytadiene (27% in YTO, 60% in ZTO). Other notable compounds included solanone, megastigmatrienone, and trans-beta-damascenone. Notably, nicotine was present in YTO but not detected in ZTO.

Behavioral Tests

Two standard anxiety models were used in male ICR mice:

• Light-Dark Box (LDB) test — mice treated with both oils spent more time in the bright (less anxiety-provoking) chamber.

• Elevated Plus Maze (EPM) test — both oils increased time spent in and entries into the open arms, indicating reduced anxiety.

Corticosterone Levels

Both YTO and ZTO significantly reduced salivary corticosterone (a stress hormone) in treated mice (p ≤ 0.001), providing a biochemical confirmation of the anxiolytic effect.

Safety

Oral doses of YTO up to 1,000 mg/kg and ZTO up to 2,000 mg/kg were found to be safe. Neither oil caused significant skin irritation at the concentrations tested.

Conclusion

Both Yunnan and Zimbabwe tobacco essential oils demonstrated clear anxiolytic effects via inhalation and transdermal routes, opening the door to potential therapeutic applications — notably without involving nicotine as the active mechanism (given ZTO showed similar effects with no detectable nicotine).

Written by Claude

 

[Asante]

I'm in Europe, northern hemisphere, so spring is coming, and thus I ordered Mapacho seeds, this time a South American variety, to see the difference in cultivation. I'll be planting it indoors on my windowsill right away, to giving it a head start to putting it in my garden. I'm hoping for a bigger crop this year, and hopefully, this time having a seed harvest.

If you live in the northern hemisphere, get your Nicotiana rustica seeds and plant indoors now.

 

[red22]

[I omitted slide 4 because of misinformation. Nicotiana tobaccum does contain MAOIs.✱]







Did you know not all tobacco is the same?
Mapacho, or Nicotiana rustica, is a potent, sacred plant used ceremonially by many Indigenous cultures of the Amazon. Unlike commercial tobacco, it has significantly more nicotine, fewer chemical additives, and is regarded as a powerful spirit ally.

Mapacho is often used for grounding, prayer, and energetic protection, a far cry from the way cigarettes are typically consumed. One is a medicine, the other an industry.

Know the difference. Respect the lineage.
Ready to deepen your understanding of sacred tobacco?

Join our Sacred Rapéh Tobacco Course and unlock profound healing and spiritual transformation by mastering the sacred practices of Rapéh and tobacco.
[https://kambospecialist.com/tobaccocourse/]

h‍ttps://www.instagram.com/medicinefrogkambo/p/DXE1Wz3lcCQ/ 2026-04-13


✱"Recently alkaloids of the harmala group, harman and norharman, have been isolated from cured commercial tobaccos and their smoke. They constitute a chemical group of beta-carbolines, which include harmine, harmaline, tetrahydroharmine, and 6-methoxy harmine, all with hallucinogenic properties. While to date no native varieties of tobacco have been analyzed for these substances, it is a reasonable supposition that their composition may vary widely, depending upon the variety and growth, and that some of the native-grown tobaccos may contain a relatively high concentration of them.[ 8 ]

8. Henry Hobhouse, Seeds of Change: Five Plants That Transformed Mankind
(New York: Harper & Row, 1985), p. 108

Food of the Gods. Terence McKenna. 1992, 1993. Chapter 11. Complacencies of the Peignoir: Sugar, Coffee, Tea, and Chocolate, pages 196-197

"Recently, positron emission tomography imaging has shown that smokers have a much lower activity of peripheral and brain MAO-A (30%) and -B (40%) isozymes compared to non-smokers."

Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors. Herraiz, T., Chaparro, C. 2005. Biochemical and biophysical research communications, 326(2), 378–386. 10.1016/j.bbrc.2004.11.033 Abstract

 

[Asante]

The synergism between Mapacho on the tongue on the plateau of Memantine is a match made in heaven.

https://www.sciencedirect.com/science/article/pii/S0887233322001515

The three men in lab coats are Albert Hofmann, flanked by Alexander Shulgin and William Leonard Pickard, three of the greatest Psychedelic Chemists.