Their are quite a few studies on sublingual and buccal administration of benzodiazepines with the papers available on-line. The conclusion was that onset and bioavailability was almost identical to IV administration. Neither are instant which I suggest is because the drug has to cross the BBB and it's that which is the limiting factor.
They are the first to point out that it's an off-label ROA BUT at least it ensures that until administration, the drug is being stored in an approved format. Solutions (e.g. injectable formulations) generally require careful formulation and almost always have a much shorter shelf-life. I don't think they become dangerous, I just think that N-oxides (for example) form which slowly reduces the amount of active.
I mean, if it psychologically makes you feel better to have a nasal spray then by all means, but it seems like a lot of research is already out there and if sublingual essentially achieves the same goal, it requires no action. You just have to remember to hold them under your tongue.
Lol using Midazolam sublingual has similar issues as trying to use the tablets for nasal just bit less annoying as it has a lot of binders and fillers and doesn't taste good I'd imagine either... I just hope it doesn't taste awful like some benzodiazepines.
I also find using benzos in a solution sublingually instead of via a crushed pill into a powder then dumped under the tongue does appear to absorb quicker and more thoroughly but that might just be placebo on me lol idk... it makes sense though.
Also the studies for sublingual aren't a good ROA for every single benzo are you sure Midzoalm is 1 of them? I'd assume it is based on the fact it's suitable for nasal administration.
If Midazolam is a benzo suitable for sublingual ROA where do I find out 100% for sure the potenital absorbption % for sublingual ROA of Midazolam which I'll make a solution out of the pills for that? Actually I just remembered that Midazolam DOES have a lower oral bioavailability but I'm not sure the difference of the sublingual vs. intranasal bioavailaiblity % but if someone with knowledge on that subject can figure it out.
Midazolam is a bit weird in terms of ROA absorption % etc. compared to most other RX benzos these days I to make a cocaine nasal spray since I have some lying around and I've always wanted to make it for various reasons like less damage to the nostrils and more effective absorption potentially but my concern has always been on how do I correctly and acccurately measure the dose per spray even if I know exactly how pure it is? its roughly 84%. What information do I need to help determine the dose per spray of liquid with I'm assuming PURIFIed and not distilled water will work and i don't need any additional solvent for cocaine as I know it's super water soluble.
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