So, right now, I am in a partial hospitalization program after having graduated from the 30 day residential program at the facility I am at right now. When I was in the residential program I was given 2 doses of 16mg Brixadi (weekly,) and it was determined to be too weak so I began the 24mg weekly and received two doses of it which worked well for me. It was just the last 24 hours before my next dose was due that was a little challenging.
They then switched me to the 96mg monthly dose on the day my usual 24mg weekly dose was due. It lasted 3 days then I began to feel it seem like it was wearing off. I went to bed, and when I woke up I was extremely irritable and my skin felt like it was crawling off. This eventually turned into muscle aches, restlessness, and extreme nausea the next day. Eventually these symptoms faded and the restlessness took over along with cravings which became quite severe initially and have been wavering in intensity ever since.
Looking at the pharmacokinetics, its obvious that the monthly dose doesn't reach steady state until 4 months out and so boosters should be used to avoid putting patients into withdrawal when transitioning from the weekly (especially considering the Cmax is about 65% lower on first dose than on 4th dose, and Cthrough is 124% lower on first dose than on 4th.) The 24mg weekly and 96mg monthly are roughly the equivalent once steady state is reached, but (again) that takes 4 doses for either one. I'm not sure why they didn't bother setting up for boosters to be given right as soon as the withdrawal began. If anyone has an idea as to why, please fill me in.
Its now been almost 2 weeks since the monthly dose was given. I was told boosters would be given after I requested medical attention, but the bosters never came (insurance issue? Idk. There has been no communication since I spoke with the prescriber who told me he was going to check if insurance would approve it, or if it needed a prior authorization.) It already took days before I saw the prescriber and by then the worst of it seemed to be over, but the restlessness and cravings have been ruining me mentally and emotionally.
Now, today, I am feeling generally unwell and I am sick of having cravings. I am not sure what to do. Other guys here have been having issues with the Brixadi shot too but it seems they're not in quite as bad shape as I am, and they've also struggled in getting medical care to resolve the issue. Initially I was told to tough it out by the first nurse I talked to, but then once I talked to the prescriber (head nurse practicioner) he told me about the boosters like I mentioned. So, I feel forgotten since its been so long since we talked and I have had no answer. I have had numerous requests sent to receive some sort of response at least, but nothing still. Maybe next week on Monday or Tuesday I will get to speak with the prescriber again, but if not I don't know what to do.
My question is what should I do here? They only offer Brixadi or naltrexone (which I don't believe would suit my condition due to the severity of it, and plus I am already established on buprenorphine for the past 2.5 months.) I was on suboxone when I got to residential here which they took away immediately and let me go into withdrawal before finally giving me the Brixadi once my insurance approved it. I am not sure if this was right of them, but its what they did even after telling the last facility I was at that they would keep me on it until the Brixadi was given. I want to switch to sublocade or back to suboxone when I leave because I am sick of the issues I have been having with the Brixadi (doses wearing off too soon.) Everyone here talks up sublocade, and I know suboxone works well for me too thus why I want to switch to either of those.
I plan to go to sober living out of state, but I am not scheduled for release until the end of the first week of September. I have been trying to find local sober living instead just to have somewhere to go until I can get things lined up for out of state so I am not in misery, but I have had no luck. I have nowhere else to go right now as I am homeless.
I just want to get better, but to get the MAT I need I would have to leave meaning nowhere to stay and no food after my little bit of savings run out. There is another program that offers MAT, but its much longer and would be a major setback. I have to get back to work as soon as possible as I haven't worked since March aside from one week before I relapsed and ended up having to go back into treatment.
Any suggestions here anyone?
They then switched me to the 96mg monthly dose on the day my usual 24mg weekly dose was due. It lasted 3 days then I began to feel it seem like it was wearing off. I went to bed, and when I woke up I was extremely irritable and my skin felt like it was crawling off. This eventually turned into muscle aches, restlessness, and extreme nausea the next day. Eventually these symptoms faded and the restlessness took over along with cravings which became quite severe initially and have been wavering in intensity ever since.
Looking at the pharmacokinetics, its obvious that the monthly dose doesn't reach steady state until 4 months out and so boosters should be used to avoid putting patients into withdrawal when transitioning from the weekly (especially considering the Cmax is about 65% lower on first dose than on 4th dose, and Cthrough is 124% lower on first dose than on 4th.) The 24mg weekly and 96mg monthly are roughly the equivalent once steady state is reached, but (again) that takes 4 doses for either one. I'm not sure why they didn't bother setting up for boosters to be given right as soon as the withdrawal began. If anyone has an idea as to why, please fill me in.
Its now been almost 2 weeks since the monthly dose was given. I was told boosters would be given after I requested medical attention, but the bosters never came (insurance issue? Idk. There has been no communication since I spoke with the prescriber who told me he was going to check if insurance would approve it, or if it needed a prior authorization.) It already took days before I saw the prescriber and by then the worst of it seemed to be over, but the restlessness and cravings have been ruining me mentally and emotionally.
Now, today, I am feeling generally unwell and I am sick of having cravings. I am not sure what to do. Other guys here have been having issues with the Brixadi shot too but it seems they're not in quite as bad shape as I am, and they've also struggled in getting medical care to resolve the issue. Initially I was told to tough it out by the first nurse I talked to, but then once I talked to the prescriber (head nurse practicioner) he told me about the boosters like I mentioned. So, I feel forgotten since its been so long since we talked and I have had no answer. I have had numerous requests sent to receive some sort of response at least, but nothing still. Maybe next week on Monday or Tuesday I will get to speak with the prescriber again, but if not I don't know what to do.
My question is what should I do here? They only offer Brixadi or naltrexone (which I don't believe would suit my condition due to the severity of it, and plus I am already established on buprenorphine for the past 2.5 months.) I was on suboxone when I got to residential here which they took away immediately and let me go into withdrawal before finally giving me the Brixadi once my insurance approved it. I am not sure if this was right of them, but its what they did even after telling the last facility I was at that they would keep me on it until the Brixadi was given. I want to switch to sublocade or back to suboxone when I leave because I am sick of the issues I have been having with the Brixadi (doses wearing off too soon.) Everyone here talks up sublocade, and I know suboxone works well for me too thus why I want to switch to either of those.
I plan to go to sober living out of state, but I am not scheduled for release until the end of the first week of September. I have been trying to find local sober living instead just to have somewhere to go until I can get things lined up for out of state so I am not in misery, but I have had no luck. I have nowhere else to go right now as I am homeless.
I just want to get better, but to get the MAT I need I would have to leave meaning nowhere to stay and no food after my little bit of savings run out. There is another program that offers MAT, but its much longer and would be a major setback. I have to get back to work as soon as possible as I haven't worked since March aside from one week before I relapsed and ended up having to go back into treatment.
Any suggestions here anyone?
