Misc Magnesium Sulphate + NMDA Antagonist/Methadone and Methoxetamine

[Gaz_hmmmm]

I know NMDA antagonists lower opioid tolerance and all through of these substances are NMDA antagonists.

I was wondering if I preload with magnesium will it kick in the Methoxetamine?

I normally take 2.5-5g of magnesium sulphate and then take my methadone as it obviously kicks ot in more, but I was wondering if the magnesium and NMDA antagonism although lower opioid tolerance actually speeds up opioid metabolism thus making WD kick in quicker?

Thanks!

 

[Gaz_hmmmm]

Bumpty bump! Maybe move this to Advanced Drug Discussion please?

 

[sekio]

Magnesium sulphate is not a very effective NMDA antagonist. It won't hurt anything but I don't think it's going to potentiate MXE notably. Both Methadone and MXE are 1000x stronger at NMDAr than Mg++ is.

You also have to account for the fact that Mg crosses the blood brain barrier rather poorly as compared to the stronger organic small-molecule drugs.


Don't bump your threads here.

 

[tricomb]

This is not Advanced Drug Discussion material, unless you feel differently Sexio?

 

[sekio]

It's not.

 

[Gaz_hmmmm]

What about the Mg Sulphate speeding up methadone/opioid metabolism and kicking withdrawl in quicker question?

Is that not ADD worthy?

Thank you guys!

 

[sekio]

Magnesium sulphate is pretty biologically inert. the most effect I have heard is that it 1. prevents magnesium deficiency (duh) and 2. makes really effective relaxing bath salts.

It is essentially no more biologically active than table salt. You can get magnesium poisoning if you eat too much of it, but mostly it will just give you the squirty shits if your dose is too high. Don't expect it to potentiate anything, block any enzymes, or change metabolism of any drugs.

In actual medical use, Mg sulphate is almost always administered as IV bolus for a few various poisonings & acute magnesium deficiency. Even then it is essentially non-psychoactive; it acts by relaxing blood vessels and muscles. (DON'T go injecting magnesium or you can stop your heart!)

Mg/Zn are overrated as NMDA antagonists, and alongside all the other drugs you are on (diazepam, 4-fa, mxe, methadone, etc) it is essentially inactive in comparison. It's like comparing chamomile tea to IV propofol.

 

[Gaz_hmmmm]

Here's some evidence that IV Mg Sulphate (I won't be injecting it, I just mix it with juice and drink it) pre-op reduces analgesic needs.

Role of Magnesium Sulfate in Postoperative Analgesia

Here's the link :- http://journals.lww.com/anesthesiology/Fulltext/1996/02000/Role_of_Magnesium_Sulfate_in_Postoperative.11.as


Edit :-

I take between 2.5-5g Mg Sulphate. Sometimes pre-loading before ingesting opiates/opioids and methoxetamine, also for muscle relaxation and sleep (Heard it's good for sleep) and for bone health as I have osteoporosis of the spine and I'm guessing shin and forearm bones as I'm getting intense pain in these areas.
I was told it could lead to osteoarthritis which I think my shin and forearm pain could be. Also for constipation cause of the opi's.

Mg Sulphate apparently has a high bioavailability out of all of the Mg salts. I've not read into celeted Mg salts much.

I have just however read the following link '11 Types of Magnesium' and can someone please explain what the part about Mg Sulphate/Sulfate means in laymen terms?



[URL="http://www.globalhealingcenter.com/natural-health/types-of-magnesium/"]http:/xwww.globalhealingcenter.com/natural-health/types-of-magnesium/