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m-MeOPP

P

Pomzazed

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Jun 10, 2007
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The firecat has obtained 3-methoxyphenylpiperazine in some quantity as a 99.5% Analytical Grade Liquid.

The known MeOPP has methoxy at 4-position, I'm wondering the effects and safety margins (apart from the LD50 value) of this substance.

Does it has any recreational value? Most amines are classed as toxic (this includes the known pFPP!) and in freebase form it could be corrosive as 3-MeOPP is a stronger base than MeOPP itself (higher electron density at the arylated nitrogen).

Thanks in advance for sharing opinions.

PS. The firecat also synthed something in piperazine class like p-methyl-o-trifluoromethylpiperazine (a p-toluene analog of TMFPP and some other alkylated N like N-benzyl-N'-tert butyl one. Doesnt want to test on himself without knowing ;P
 
looks like it could be a potentially toxic drug, and the effects certainly wouldn't be anything to write home about.

proceed with caution, personally i wouldn't touch it with a 10-ft pole
 
Right, hence on the papers they reasearched much on piperazine class as in MDMA comparison. and seems that it somewhat binds to the same receptors on some piperazine structure.

The problem is whether they are deadly/permanent toxic? also their metabolites?
 
^^

good clarification

and to note the one that has been experienced by some is i believe p-MeOPP, noted to have some very MDMA/MDA like characteristics
 
I have to ask myself when I find MDMA/MDA like moments on these piperazines if it because thats what they were advertised since their release, Herbal/Legal E etc.

You can feel MDMA like characteristics on lots of drugs, even 5-meo-dipt, 4-FMP, even sometimes a low dose of the right mushroom strain at certain doses.

When I felt MDMA moment on mCPP, I realised what people were talking about, then I snapped out of it and realised I was in some sort of mental-soup that basically felt like a poison. Why do piperazines change so much from person to person. I've disliked them all. I've became a bit of an anxious over thinking person because of too many drugs, but these piperazines can just make me plain panic for no reason, especially mCPP. And a nice shot of meth won't do that.
 
Yeah, lots of 5-HT2C activation will do that. That is what gets mCPP labeled as a "panicogen" ...
 
MBZP is similar, but more "gentle" than BZP, in my experience.
(Assuming you mean 1-benzyl-4-methylpiperazine, by MBZP)
 
My memory is hazy on the experiments i did with it, but from memory the dose required for a level of stimulation compared to plain BZP was about 1.5x. Felt different too - it was never as full-on as BZP can be, never felt forced. It was a smooth ride up and down. Slightly shorter duration. Had a greater capacity to cause visual distortions. While plain BZP can give me some very minor geometric patters with eyes closed, MBZP was capable of giving me shimmering edges on objects with eyes open and the like, I think at maybe a 300-350mg dose.

One of my favorite piperazine combos was BZP + TFMPP + MBZP. In a roughly 2:1:1 ratio, respectively. (I don't like the piperazines much, but this combo was the most liked way in which I could use them!)
 
I personally think that all of the piperazines are nasty nasty stuff and wouldn't touch them with a shitty stick. BZP (& associated benzylpiperazines) are probably the safest of the bunch, but the phenylpiperazines are effectively derivatives of aniline & therefore aromatic amines; if you do a bit of searching on te toxicology of aromatic amines you'll see that most are nasty, unpleasant shit and best avoided (even drugs that contain an aromatic amine structure, like nomifensine, are implicated in all sorts of nasty, toxic side effects).

That's without getting into the fact that the ones of interest here are potential panicogens, m-MeOPP just being the latest of the bunch.

That's just my personal opinion on them, not anything that I've seen in scientific journals (except for the panicogen comment) so take it at whatever value you want.
 
wungchow said:
if you're into testing novel stims, try 2-benzylpiperidine
Click to expand...

Do you mean 2-benzylpiperizine or 2-benzylpiperidine? Remember the infamous MPPP/MPTP debacle of the 1980's? The molecule was reduced into the highly reactive MPP+ which nearly destroyed all of the dopaminergic neurons of the substantia nigra, causing a type of Parkinsonism.

Be careful with these very simple piperidine derivatives as MPPP was almost as simple an opioid as there is, and the CYP450 enzymes will always try to make a reactive group that is often susceptible to oxidation during phase I biotransformation. Any hydroxy group could cause this type of fiasco on these molecules.

Although I know that the following example is not similar to the molecules which you are referring, I always keep it in mind as an example of just how sensitive dopaminergic neurons are: 6-hydroxy dopamine is used to create lesions in the nigrostriatal area of the brain and we use it today as a model for Parkinson's Disease in rats.

MobiusDick

Q: "What happened to my Honda?"
A: "Baby, I had to wreck that Honda!"
 
The molecule was reduced into the highly reactive MPP+ which nearly destroyed all of the dopaminergic neurons of the substantia nigra, causing a type of Parkinsonism.
Click to expand...


It was actually oxidized to MPP+, not reduced. Also, that molecule had a methyl group attached to the ring nitrogen making it effectively a quaternary amine in MPP+; 2-benzylpiperidine is a secondary amine, lacking any alkyl group on the ring nitrogen so that if oxidized it becomes 2-benzylpyridine, which as far as I know does not show the same toxicological activity as MPTP
 
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